{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:20:57Z","timestamp":1773134457475,"version":"3.50.1"},"reference-count":54,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"accepted":{"date-parts":[[2020,12,22]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>To compare the efficacy of deep brain stimulation (DBS) and MRI-guided focused ultrasound (MRIgFUS) in parkinsonian tremor. We performed a network meta-analysis based on a Bayesian framework. We searched the literature for articles published between January 1990 and October 2020 using three databases: PubMed, Embase and Cochrane Library (The Cochrane Database of Systematic Reviews). A total of 24 studies were included in our analysis, comprising data from 784 participants. Our findings revealed similar efficacy of DBS and MRIgFUS in parkinsonian tremor suppression. Compared with internal globus pallidus (GPi)-MRIgFUS, GPi-DBS -1.84 (\u20136.44, 2.86), pedunculopontine nucleus (PPN)_DBS \u20133.28 (\u20139.28, 2.78), PPN and caudal zona incerta (cZI)-DBS 0.40 (\u20136.16, 6.87), subthalamic nucleus (STN)_DBS 0.89 (\u20133.48, 5.30), STN and cZI-DBS 1.99 (\u20134.74, 8.65), ventral intermediate nucleus(VIM)_DBS 1.75 (\u20132.87, 6.48), VIM_FUS 0.72 (\u20135.27, 6.43), cZI-DBS 0.27 (\u20134.75, 5.36) were no significantly difference. Compared with VIM-MRIgFUS, GPi-DBS -2.55(-6.94, 2.21), GPi-FUS -0.72 (\u20136.43, 5.27), PPN_DBS -4.01(\u20139.97, 2.11), PPN and cZI-DBS -0.32 (-6.73, 6.36), STN_DBS 0.16 (\u20133.98, 4.6), STN and cZI-DBS 1.31(-5.18,7.87), VIM-DBS 1.00(-3.41, 5.84)and cZI-DBS \u20130.43 (\u20135.07, 4.68) were no significantly difference. With respect to the results for the treatment of motor symptoms, GPi-DBS, GPi-MRIgFUS, STN-DBS and cZI-DBS were significantly more efficacious than baseline (GPi-DBS 15.24 (5.79, 24.82), GPi-MRIgFUS 13.46 (2.46, 25.10), STN-DBS 19.62 (12.19, 27.16), cZI-DBS 14.18 (1.73, 26.89). The results from the surface under the cumulative ranking results showed that STN-DBS ranked first, followed by combined PPN and cZI-DBS, and PPN-DBS ranked last. MRIgFUS, an efficacious intervention for improving parkinsonian tremor, has not demonstrated to be inferior to DBS in parkinsonian tremor suppression. Hence, clinicians should distinguish individual patients\u2019 symptoms to ensure that the appropriate intervention and therapeutic approach are applied.<\/jats:p>","DOI":"10.1136\/jnnp-2020-323656","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T16:21:56Z","timestamp":1615566116000},"page":"434-443","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Comparison of efficacy of deep brain stimulation and focused ultrasound in parkinsonian tremor: a systematic review and network meta-analysis"],"prefix":"10.1136","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7628-9152","authenticated-orcid":false,"given":"Fabin","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dihang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huidan","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinyong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7628-9152","authenticated-orcid":false,"given":"Guoen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2024120323350762000_92.4.434.1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5694\/j.1326-5377.2010.tb03453.x","article-title":"Current concepts in the management of Parkinson disease","volume":"192","author":"Hayes","year":"2010","journal-title":"Med J Aust"},{"key":"2024120323350762000_92.4.434.2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198908000-00006"},{"key":"2024120323350762000_92.4.434.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.929"},{"key":"2024120323350762000_92.4.434.4","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/cns.12512","article-title":"Functional Connectivity of Vim Nucleus in Tremor- and Akinetic-\/Rigid-Dominant Parkinson\u2019s Disease","volume":"22","author":"Zhang","year":"2016","journal-title":"CNS Neurosci Ther"},{"key":"2024120323350762000_92.4.434.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035275"},{"key":"2024120323350762000_92.4.434.6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.parkreldis.2018.08.017","article-title":"Stn vs. GPI deep brain stimulation for tremor suppression in Parkinson disease: a systematic review and meta-analysis","volume":"58","author":"Wong","year":"2019","journal-title":"Parkinsonism Relat Disord"},{"key":"2024120323350762000_92.4.434.7","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1001\/jamaneurol.2017.3098","article-title":"Safety and efficacy of focused ultrasound thalamotomy for patients with Medication-Refractory, Tremor-Dominant Parkinson disease: a randomized clinical trial","volume":"74","author":"Bond","year":"2017","journal-title":"JAMA Neurol"},{"key":"2024120323350762000_92.4.434.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600159"},{"key":"2024120323350762000_92.4.434.9","first-page":"417","article-title":"Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: a 5-year single-center experience","author":"Sinai","year":"2019","journal-title":"J Neurosurg"},{"key":"2024120323350762000_92.4.434.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2008.00347.x"},{"key":"2024120323350762000_92.4.434.11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k585"},{"key":"2024120323350762000_92.4.434.12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f3675"},{"key":"2024120323350762000_92.4.434.13","doi-asserted-by":"crossref","unstructured":"Dias S , Caldwell DM . 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