{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:11:51Z","timestamp":1791911511273,"version":"4.3.4"},"reference-count":38,"publisher":"BMJ","issue":"12","funder":[{"name":"Chinese Institute for Brain Research","award":["Z181100001518005"],"award-info":[{"award-number":["Z181100001518005"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"accepted":{"date-parts":[[2020,9,6]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To study the efficacy and safety of bilateral globus pallidus internus deep brain stimulation (GPi-DBS) in refractory Meige syndrome (MS) and evaluate the psychiatric disorders before and after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-two patients with MS treated with bilateral GPi-DBS were retrospectively analysed before surgery and after continuous neurostimulation. Before surgery, patients were assessed by the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), Self-Rating Depression Scale, Medical Outcomes Study 36-Item Short-Form General Health Survey (SF-36) and Pittsburgh Sleep Quality Index (PQSI), which corresponded to motor symptoms, depressive state, quality of life and sleep quality, respectively. The implantable pulse generator of each patient was activated at 1 month after surgery. At 1 month, 3 months, 6 months and 12 months after continuous neurostimulation, all patients were evaluated by the same scales above.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The BFMDRS movement scores decreased from 15.0\u00b15.3 before surgery to 3.5\u00b14.5 at 12 months after neurostimulation, with a mean improvement of 78% (p&lt;0.001). The BFMDRS disability scores improved from 7.4\u00b14.9 before surgery to 4.0\u00b14.6 at 12 months after neurostimulation, with a mean improvement of 56% (p&lt;0.001). The postoperative SF-36 scores had the remarkable improvement compared with baseline scores. Impaired sleep quality was found in 82% of patients and depression in 64% before surgery, which didn\u2019t neither obtained amelioration after continuous neurostimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bilateral pallidal neurostimulation is a beneficial therapeutic option for refractory MS, which could improve the motor symptoms except for depression and sleep quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jnnp-2020-323701","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T17:20:48Z","timestamp":1602091248000},"page":"1343-1348","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Pallidal deep brain stimulation in primary Meige syndrome: clinical outcomes and psychiatric 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