{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:20:59Z","timestamp":1767910859376,"version":"3.49.0"},"reference-count":47,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>Pregnancy largely affects disease activity and clinical course in women with immune-mediated neurological disorders. Chronic inflammatory demyelinating polyneuropathy (CIDP) is rare but the most common chronic immune-mediated neuropathy; however, the effects of pregnancy on CIDP have never been investigated except case reports or series. We here provide a systematic review of the literature from 1 January 1969 to 30 June 2020 that revealed 24 women with CIDP, who had onset or relapse during pregnancy. Of these, 17 (71%) developed CIDP during the first pregnancy, and 8 (47%) had a relapse during subsequent pregnancies. Of the 17 patients, in whom the CIDP subtypes were determined, all of them had typical CIDP. First-line treatments for CIDP, such as corticosteroids, immunoglobulin and plasma exchange were efficacious and safe. We suggest that pregnancy can trigger typical CIDP in some women, and women with CIDP have a higher risk of relapse during pregnancy. The onset or relapse of CIDP during pregnancy is a rare but challenging constellation for physicians.<\/jats:p>","DOI":"10.1136\/jnnp-2020-325321","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T03:25:04Z","timestamp":1612927504000},"page":"473-478","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Chronic inflammatory demyelinating polyneuropathy and pregnancy: systematic review"],"prefix":"10.1136","volume":"92","author":[{"given":"Felix","family":"Kohle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4716-8578","authenticated-orcid":false,"given":"Satoshi","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6205-2293","authenticated-orcid":false,"given":"Helmar Christoph","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"2022011608400587000_92.5.473.1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00187.x"},{"key":"2022011608400587000_92.5.473.2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-320314"},{"key":"2022011608400587000_92.5.473.3","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12190"},{"key":"2022011608400587000_92.5.473.4","first-page":"p. 849","article-title":"[Clinical investigation of inflammatory polyradiculoneuritis in France]","volume":"115","author":"Castaigne","year":"1966","journal-title":"Rev Neurol"},{"key":"2022011608400587000_92.5.473.5","first-page":"621","article-title":"Chronic inflammatory polyradiculoneuropathy","volume":"50","author":"Dyck","year":"1975","journal-title":"Mayo Clin Proc"},{"key":"2022011608400587000_92.5.473.6","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210120"},{"key":"2022011608400587000_92.5.473.7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"2022011608400587000_92.5.473.8","doi-asserted-by":"crossref","unstructured":"Higgins JPT TJ , Chandler J , Cumpston M . Cochrane handbook for systematic reviews of interventions version 6.0. chapter 5: collecting data, 2019. Available: www.training.cochrane.org\/handbook [Accessed 20 Jul 2020].","DOI":"10.1002\/9781119536604"},{"key":"2022011608400587000_92.5.473.9","doi-asserted-by":"publisher","DOI":"10.1053\/rapm.2002.29719"},{"key":"2022011608400587000_92.5.473.10","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1097\/00000539-200111000-00055","article-title":"Subarachnoid block for a patient with progressive chronic inflammatory demyelinating polyneuropathy","volume":"93","author":"Schabel","year":"2001","journal-title":"Anesth Analg"},{"key":"2022011608400587000_92.5.473.11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s00540-011-1296-z","article-title":"Spinal anesthesia for cesarean section in a patient with chronic inflammatory demyelinating polyradiculoneuropathy","volume":"26","author":"Richter","year":"2012","journal-title":"J Anesth"},{"key":"2022011608400587000_92.5.473.12","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490220027002"},{"key":"2022011608400587000_92.5.473.13","first-page":"33","article-title":"[Guillain-Barre syndrome in pregnancy]","volume":"141","author":"d'Ambrosio","year":"1985","journal-title":"Rev Neurol"},{"key":"2022011608400587000_92.5.473.14","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJM197006042822308","article-title":"Recurrent polyneuropathy with pregnancy and oral contraceptives","volume":"282","author":"Calder\u00f3n-Gonz\u00e1lez","year":"1970","journal-title":"N Engl J Med"},{"key":"2022011608400587000_92.5.473.15","first-page":"206","article-title":"Isaac's syndrome associated with CIDP and pregnancy","volume":"14","author":"Basiri","year":"2011","journal-title":"Arch Iran Med"},{"key":"2022011608400587000_92.5.473.16","first-page":"78","article-title":"[Rapid spontaneous postpartum remission in a case of chronic inflammatory demyelinating polyradiculoneuropathy associated with pregnancy]","volume":"32","author":"Kawada","year":"1992","journal-title":"Rinsho Shinkeigaku"},{"key":"2022011608400587000_92.5.473.17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.5692\/clinicalneurol.cn-001104","article-title":"[A case of chronic inflammatory demyelinating polyradiculoneuropathy presenting recurrent attacks associated with pregnancies]","volume":"58","author":"Shiraishi","year":"2018","journal-title":"Rinsho Shinkeigaku"},{"key":"2022011608400587000_92.5.473.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00278.x"},{"key":"2022011608400587000_92.5.473.19","doi-asserted-by":"crossref","DOI":"10.1002\/ana.410090419","article-title":"Chronic relapsing polyneuritis associated with pregnancy","volume":"9","author":"Jones","year":"1981","journal-title":"Ann Neurol"},{"key":"2022011608400587000_92.5.473.20","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090719"},{"key":"2022011608400587000_92.5.473.21","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-15506"},{"key":"2022011608400587000_92.5.473.22","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.3.498"},{"key":"2022011608400587000_92.5.473.23","doi-asserted-by":"crossref","first-page":"v70","DOI":"10.1007\/s00415-006-5012-0","article-title":"Intravenous immunoglobulin therapy in neurological diseases during pregnancy","volume":"253","author":"Ringel","year":"2006","journal-title":"J Neurol"},{"key":"2022011608400587000_92.5.473.24","first-page":"Cd010369","article-title":"Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews","volume":"1","author":"Oaklander","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"2022011608400587000_92.5.473.25","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20583"},{"key":"2022011608400587000_92.5.473.26","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208840"},{"key":"2022011608400587000_92.5.473.27","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000453"},{"key":"2022011608400587000_92.5.473.28","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0034-x"},{"key":"2022011608400587000_92.5.473.29","doi-asserted-by":"crossref","unstructured":"Ertenli \u00dd . AB0079 cyclophosphamide exposure during pregnancy: two cases. Ann Rheum Dis 2001;60.","DOI":"10.1136\/annrheumdis-2001.124"},{"key":"2022011608400587000_92.5.473.30","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/00000539-200001000-00045","article-title":"The prolonged effect of a muscle relaxant in a patient with chronic inflammatory demyelinating polyradiculoneuropathy","volume":"90","author":"Hara","year":"2000","journal-title":"Anesth Analg"},{"key":"2022011608400587000_92.5.473.31","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/00000542-199005000-00026","article-title":"Cardiac arrest after succinylcholine administration in a pregnant patient recovered from Guillain-Barr\u00e9 syndrome","volume":"72","author":"Feldman","year":"1990","journal-title":"Anesthesiology"},{"key":"2022011608400587000_92.5.473.32","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.179358"},{"key":"2022011608400587000_92.5.473.33","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70215-1"},{"key":"2022011608400587000_92.5.473.34","first-page":"319","article-title":"Guillain-barr\u00e9 syndrome in pregnancy: an unusual case","volume":"83","author":"Chan","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2022011608400587000_92.5.473.35","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/00001648-199811000-00006","article-title":"Increased incidence of Guillain-Barr\u00e9 syndrome postpartum","volume":"9","author":"Cheng","year":"1998","journal-title":"Epidemiology"},{"key":"2022011608400587000_92.5.473.36","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/AOG.0000000000001716","article-title":"Guillain-Barr\u00e9 syndrome in pregnancy","volume":"128","author":"Pacheco","year":"2016","journal-title":"Obstet Gynecol"},{"key":"2022011608400587000_92.5.473.37","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181aaea47"},{"key":"2022011608400587000_92.5.473.38","article-title":"Systemic IGF-1 gene delivery by rAAV9 improves spontaneous autoimmune peripheral polyneuropathy (sAPP)","volume":"8","author":"Gao","year":"2018","journal-title":"Sci Rep"},{"key":"2022011608400587000_92.5.473.39","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390501"},{"key":"2022011608400587000_92.5.473.40","doi-asserted-by":"crossref","first-page":"e832","DOI":"10.1212\/WNL.0000000000005068","article-title":"Pregnancy decision-making in women with multiple sclerosis treated with natalizumab: II: maternal risks","volume":"90","author":"Portaccio","year":"2018","journal-title":"Neurology"},{"key":"2022011608400587000_92.5.473.41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.berh.2017.09.011","article-title":"Pregnancy in systemic lupus erythematosus and antiphospholipid syndrome","volume":"31","author":"Fischer-Betz","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2022011608400587000_92.5.473.42","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.clim.2016.08.014","article-title":"The immunoendocrinology of systemic lupus erythematosus","volume":"172","author":"Lahita","year":"2016","journal-title":"Clin Immunol"},{"key":"2022011608400587000_92.5.473.43","doi-asserted-by":"crossref","first-page":"644","DOI":"10.4049\/jimmunol.156.2.644","article-title":"Pregnancy impairs resistance of C57BL\/6 mice to Leishmania major infection and causes decreased antigen-specific IFN-gamma response and increased production of T helper 2 cytokines","volume":"156","author":"Krishnan","year":"1996","journal-title":"J Immunol"},{"key":"2022011608400587000_92.5.473.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2008.04.001"},{"key":"2022011608400587000_92.5.473.45","doi-asserted-by":"publisher","DOI":"10.1002\/art.10248"},{"key":"2022011608400587000_92.5.473.46","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/00000441-199204000-00003","article-title":"Hyperprolactinemia in systemic lupus erythematosus: association with disease activity","volume":"303","author":"Jara","year":"1992","journal-title":"Am J Med Sci"},{"key":"2022011608400587000_92.5.473.47","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.6.1935"}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2020-325321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T22:08:20Z","timestamp":1697839700000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2020-325321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,9]]},"references-count":47,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,4,15]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1136\/jnnp-2020-325321"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2020-325321","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,9]]}}}