{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:57:34Z","timestamp":1788955054524,"version":"build-2803163510"},"reference-count":46,"publisher":"BMJ","issue":"10","funder":[{"name":"The Hori Sciences and Arts Foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ak0101111"],"award-info":[{"award-number":["JP22ak0101111"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ak0101124"],"award-info":[{"award-number":["JP22ak0101124"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22bm0804020"],"award-info":[{"award-number":["JP22bm0804020"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ek0109492"],"award-info":[{"award-number":["JP22ek0109492"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ek0109538"],"award-info":[{"award-number":["JP22ek0109538"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22wm0425009"],"award-info":[{"award-number":["JP22wm0425009"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["20FC1049"],"award-info":[{"award-number":["20FC1049"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SERIKA FUND","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H03576"],"award-info":[{"award-number":["19H03576"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K06523"],"award-info":[{"award-number":["19K06523"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K07973"],"award-info":[{"award-number":["19K07973"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H00485"],"award-info":[{"award-number":["20H00485"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H02988"],"award-info":[{"award-number":["22H02988"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07359"],"award-info":[{"award-number":["22K07359"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07509"],"award-info":[{"award-number":["22K07509"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Several genetic factors are associated with the pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) and its phenotypes, such as disease progression. Here, in this study, we aimed to identify the genes that affect the survival of patients with sporadic ALS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 1076 Japanese patients with sporadic ALS with imputed genotype data of 7 908 526 variants. We used Cox proportional hazards regression analysis with an additive model adjusted for sex, age at onset and the first two principal components calculated from genotyped data to conduct a genome-wide association study. We further analysed messenger RNA (mRNA) and phenotype expression in motor neurons derived from induced pluripotent stem cells (iPSC-MNs) of patients with ALS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three novel loci were significantly associated with the survival of patients with sporadic ALS\u2014<jats:italic>FGF1<\/jats:italic>at 5q31.3 (rs11738209, HR=2.36 (95% CI, 1.77 to 3.15), p=4.85\u00d710<jats:sup>\u22129<\/jats:sup>),<jats:italic>THSD7A<\/jats:italic>at 7p21.3 (rs2354952, 1.38 (95% CI, 1.24 to 1.55), p=1.61\u00d710<jats:sup>\u22128<\/jats:sup>) and<jats:italic>LRP1<\/jats:italic>at 12q13.3 (rs60565245, 2.18 (95% CI, 1.66 to 2.86), p=2.35\u00d710<jats:sup>\u22128<\/jats:sup>).<jats:italic>FGF1<\/jats:italic>and<jats:italic>THSD7A<\/jats:italic>variants were associated with decreased mRNA expression of each gene in iPSC-MNs and reduced in vitro survival of iPSC-MNs obtained from patients with ALS. The iPSC-MN in vitro survival was reduced when the expression of<jats:italic>FGF1<\/jats:italic>and<jats:italic>THSD7A<\/jats:italic>was partially disrupted. The rs60565245 was not associated with<jats:italic>LRP1<\/jats:italic>mRNA expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We identified three loci associated with the survival of patients with sporadic ALS, decreased mRNA expression of<jats:italic>FGF1<\/jats:italic>and<jats:italic>THSD7A<\/jats:italic>and the viability of iPSC-MNs from patients. The iPSC-MN model reflects the association between patient prognosis and genotype and can contribute to target screening and validation for therapeutic intervention.<\/jats:p><\/jats:sec>","DOI":"10.1136\/jnnp-2022-330851","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T17:21:49Z","timestamp":1683220909000},"page":"816-824","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients"],"prefix":"10.1136","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-3579","authenticated-orcid":false,"given":"Ryoichi","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genki","family":"Tohnai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-4837","authenticated-orcid":false,"given":"Masahiro","family":"Nakatochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Atsuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-9311","authenticated-orcid":false,"given":"Masahisa","family":"Katsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Hirakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuishin","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuya","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehisa","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Kano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-8554","authenticated-orcid":false,"given":"Naoki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1734-7997","authenticated-orcid":false,"given":"Ichiro","family":"Yabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4061-0412","authenticated-orcid":false,"given":"Kazumoto","family":"Shibuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4716-8578","authenticated-orcid":false,"given":"Satoshi","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-5472","authenticated-orcid":false,"given":"Osamu","family":"Onodera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Mizoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-2693","authenticated-orcid":false,"given":"Fumiaki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Doyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikashi","family":"Terao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Ikegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Fujimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Onodera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4769-5922","authenticated-orcid":false,"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"2023092610152089000_94.10.816.1","doi-asserted-by":"crossref","unstructured":"Brown RH , Al-Chalabi A . Amyotrophic lateral sclerosis. N Engl J Med 2017;377:1602. doi:10.1056\/NEJMc1710379","DOI":"10.1056\/NEJMc1710379"},{"key":"2023092610152089000_94.10.816.2","doi-asserted-by":"publisher","DOI":"10.1038\/362059a0"},{"key":"2023092610152089000_94.10.816.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154584"},{"key":"2023092610152089000_94.10.816.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"2023092610152089000_94.10.816.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"2023092610152089000_94.10.816.6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-315018"},{"key":"2023092610152089000_94.10.816.7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neurobiolaging.2015.11.030","article-title":"Next-Generation sequencing of 28 ALS-related genes in a Japanese ALS cohort","volume":"39","author":"Nakamura","year":"2016","journal-title":"Neurobiol Aging"},{"key":"2023092610152089000_94.10.816.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00973-1"},{"key":"2023092610152089000_94.10.816.9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s42003-020-01251-2","article-title":"A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis","volume":"3","author":"Nakamura","year":"2020","journal-title":"Commun Biol"},{"key":"2023092610152089000_94.10.816.10","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1001\/jamaneurol.2016.1114","article-title":"Association of a locus in the CAMTA1 gene with survival in patients with sporadic amyotrophic lateral sclerosis","volume":"73","author":"Fogh","year":"2016","journal-title":"JAMA Neurol"},{"key":"2023092610152089000_94.10.816.11","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1007\/s10072-019-03951-y","article-title":"UNC13A variant rs12608932 is associated with increased risk of amyotrophic lateral sclerosis and reduced patient survival: a meta-analysis","volume":"40","author":"Yang","year":"2019","journal-title":"Neurol Sci"},{"key":"2023092610152089000_94.10.816.12","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/ana.25841","article-title":"The distinct traits of the UNC13A polymorphism in amyotrophic lateral sclerosis","volume":"88","author":"Tan","year":"2020","journal-title":"Ann Neurol"},{"key":"2023092610152089000_94.10.816.13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812937106"},{"key":"2023092610152089000_94.10.816.14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914079107"},{"key":"2023092610152089000_94.10.816.15","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1016\/j.neurobiolaging.2014.04.014","article-title":"Analysis of the kifap3 gene in amyotrophic lateral sclerosis: a multicenter survival study","volume":"35","author":"van Doormaal","year":"2014","journal-title":"Neurobiol Aging"},{"key":"2023092610152089000_94.10.816.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.10.029"},{"key":"2023092610152089000_94.10.816.17","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s12017-020-08634-y","article-title":"Association of single nucleotide polymorphism at rs2275294 in the ZNF512B gene with prognosis in amyotrophic lateral sclerosis","volume":"23","author":"Jiang","year":"2021","journal-title":"Neuromolecular Med"},{"key":"2023092610152089000_94.10.816.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.12.055"},{"key":"2023092610152089000_94.10.816.19","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-311541"},{"key":"2023092610152089000_94.10.816.20","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/s41591-018-0140-5","article-title":"Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent","volume":"24","author":"Fujimori","year":"2018","journal-title":"Nat Med"},{"key":"2023092610152089000_94.10.816.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.01.007"},{"key":"2023092610152089000_94.10.816.22","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306020"},{"key":"2023092610152089000_94.10.816.23","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"2023092610152089000_94.10.816.24","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1414"},{"key":"2023092610152089000_94.10.816.25","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3656"},{"key":"2023092610152089000_94.10.816.26","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"2023092610152089000_94.10.816.27","doi-asserted-by":"crossref","unstructured":"Aulchenko YS , Struchalin MV , van Duijn CM . ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinformatics 2010;11:134. doi:10.1186\/1471-2105-11-134","DOI":"10.1186\/1471-2105-11-134"},{"key":"2023092610152089000_94.10.816.28","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.1999.00997.x"},{"key":"2023092610152089000_94.10.816.29","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq340"},{"key":"2023092610152089000_94.10.816.30","doi-asserted-by":"crossref","unstructured":"Wang K , Li M , Hakonarson H . ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 2010;38:e164. doi:10.1093\/nar\/gkq603","DOI":"10.1093\/nar\/gkq603"},{"key":"2023092610152089000_94.10.816.31","doi-asserted-by":"crossref","unstructured":"Onodera K , Shimojo D , Ishihara Y , et al . Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs. Mol Brain 2020;13:18. doi:10.1186\/s13041-020-0561-1","DOI":"10.1186\/s13041-020-0561-1"},{"key":"2023092610152089000_94.10.816.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"2023092610152089000_94.10.816.33","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/ana.26047","article-title":"Prediction model of amyotrophic lateral sclerosis by deep learning with patient induced pluripotent stem cells","volume":"89","author":"Imamura","year":"2021","journal-title":"Ann Neurol"},{"key":"2023092610152089000_94.10.816.34","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s10072-014-1656-1","article-title":"Association analysis of four candidate genetic variants with sporadic amyotrophic lateral sclerosis in a Chinese population","volume":"35","author":"Chen","year":"2014","journal-title":"Neurol Sci"},{"key":"2023092610152089000_94.10.816.35","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04436-3"},{"key":"2023092610152089000_94.10.816.36","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04424-7"},{"key":"2023092610152089000_94.10.816.37","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/BF00313611","article-title":"Insulin-Like and fibroblast growth factors in spinal cords, nerve roots and skeletal muscle of human controls and patients with amyotrophic lateral sclerosis","volume":"87","author":"Kerkhoff","year":"1994","journal-title":"Acta Neuropathol"},{"key":"2023092610152089000_94.10.816.38","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200112040-00040"},{"key":"2023092610152089000_94.10.816.39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501920200"},{"key":"2023092610152089000_94.10.816.40","doi-asserted-by":"crossref","unstructured":"Arslanbaeva L , Bisaglia M . Activation of the Nrf2 pathway as a therapeutic strategy for ALS treatment. Molecules 2022;27:1471. doi:10.3390\/molecules27051471","DOI":"10.3390\/molecules27051471"},{"key":"2023092610152089000_94.10.816.41","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21990"},{"key":"2023092610152089000_94.10.816.42","doi-asserted-by":"crossref","unstructured":"Kuo M-W , Wang C-H , Wu H-C , et al . Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis. PLoS One 2011;6:e29000. doi:10.1371\/journal.pone.0029000","DOI":"10.1371\/journal.pone.0029000"},{"key":"2023092610152089000_94.10.816.43","doi-asserted-by":"crossref","unstructured":"Liu L-M , Lin M-H , Lai Z-Y , et al . Motor neuron-derived thsd7a is essential for zebrafish vascular development via the notch-dll4 signaling pathway. J Biomed Sci 2016;23:59. doi:10.1186\/s12929-016-0277-9","DOI":"10.1186\/s12929-016-0277-9"},{"key":"2023092610152089000_94.10.816.44","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24936"},{"key":"2023092610152089000_94.10.816.45","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy384"},{"key":"2023092610152089000_94.10.816.46","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000285080.70324.27"}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2022-330851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T17:18:34Z","timestamp":1695748714000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2022-330851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,4]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,9,26]]},"published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1136\/jnnp-2022-330851"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2022-330851","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,4]]}}}