{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:32:37Z","timestamp":1775093557174,"version":"3.50.1"},"reference-count":15,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000381","name":"Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["147"],"award-info":[{"award-number":["147"]}],"id":[{"id":"10.13039\/501100000381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"accepted":{"date-parts":[[2024,4,29]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Identification of multiple sclerosis (MS) cases in routine healthcare data repositories remains challenging. MS can have a protracted diagnostic process and is rarely identified as a primary reason for admission to the hospital. Difficulties in identification are compounded in systems that do not include insurance or payer information concerning drug treatments or non-notifiable disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To develop an algorithm to reliably identify MS cases within a national health data bank.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective analysis of the Secure Anonymised Information Linkage (SAIL) databank was used to identify MS cases using a novel algorithm. Sensitivity and specificity were tested using two existing independent MS datasets, one clinically validated and population-based and a second from a self-registered MS national registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 4\u2009757\u2009428 records, the algorithm identified 6194 living cases of MS within Wales on 31 December 2020 (prevalence 221.65 (95% CI 216.17 to 227.24) per 100 000). Case-finding sensitivity and specificity were 96.8% and 99.9% for the clinically validated population-based cohort and sensitivity was 96.7% for the self-declared registry population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The algorithm successfully identified MS cases within the SAIL databank with high sensitivity and specificity, verified by two independent populations and has important utility in large-scale epidemiological studies of MS.<\/jats:p><\/jats:sec>","DOI":"10.1136\/jnnp-2024-333532","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T17:20:58Z","timestamp":1716484858000},"page":"1032-1035","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales"],"prefix":"10.1136","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0414-1225","authenticated-orcid":false,"given":"Richard","family":"Nicholas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-6634","authenticated-orcid":false,"given":"Emma Clare","family":"Tallantyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Witts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-5595","authenticated-orcid":false,"given":"Ruth Ann","family":"Marrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-9942","authenticated-orcid":false,"given":"Elaine M","family":"Craig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-0200","authenticated-orcid":false,"given":"Owen Rhys","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Harding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Kreft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hawken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Ingram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethan","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2130-4420","authenticated-orcid":false,"given":"Rodden M","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"UKMS Register","family":"Research Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"2024101603401075000_95.11.1032.1","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s10620-019-06039-x","article-title":"Clinical Ontologies improve case finding of primary biliary cholangitis in UK primary and secondary care","volume":"65","author":"Pericleous","year":"2020","journal-title":"Dig Dis Sci"},{"key":"2024101603401075000_95.11.1032.2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036192"},{"key":"2024101603401075000_95.11.1032.3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"2024101603401075000_95.11.1032.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2014.01.003"},{"key":"2024101603401075000_95.11.1032.5","unstructured":"WHO . ICD-10 Version:2010. ICD-10 Version2010, 2010. Available: https:\/\/icd.who.int\/browse10\/2010\/en [Accessed 28 Apr 2021]."},{"key":"2024101603401075000_95.11.1032.6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2532.1994.1130177.x"},{"key":"2024101603401075000_95.11.1032.7","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2017.301"},{"key":"2024101603401075000_95.11.1032.8","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-330013"},{"key":"2024101603401075000_95.11.1032.9","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"2024101603401075000_95.11.1032.10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cf6ec0"},{"key":"2024101603401075000_95.11.1032.11","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(16)32298-X","article-title":"The UK secure eResearch platform for public health research: a case study","volume":"388","author":"Jones","year":"2016","journal-title":"The Lancet"},{"key":"2024101603401075000_95.11.1032.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.05.015"},{"key":"2024101603401075000_95.11.1032.13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155181","article-title":"Sunshine, sea, and season of birth: MS incidence in Wales","volume":"11","author":"Balbuena","year":"2016","journal-title":"PLOS ONE"},{"key":"2024101603401075000_95.11.1032.14","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.144667"},{"key":"2024101603401075000_95.11.1032.15","unstructured":"Number of people with MS | Atlas of MS, Available: https:\/\/www.atlasofms.org\/map\/global\/epidemiology\/number-of-people-with-ms [Accessed 15 Mar 2024]."}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2024-333532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T10:40:26Z","timestamp":1729075226000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2024-333532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":15,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,10,16]]},"published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1136\/jnnp-2024-333532"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2024-333532","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,23]]}}}