{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:04:03Z","timestamp":1793163843189,"version":"4.5.0"},"reference-count":37,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019563","name":"Danish Epilepsy Association","doi-asserted-by":"crossref","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100019563","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R400-2022-1205"],"award-info":[{"award-number":["R400-2022-1205"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"crossref","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009708","name":"The Novo Nordisk Foundation","doi-asserted-by":"crossref","award":["NNF16OC0019126"],"award-info":[{"award-number":["NNF16OC0019126"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009708","name":"The Novo Nordisk Foundation","doi-asserted-by":"crossref","award":["NNF22OC0075033"],"award-info":[{"award-number":["NNF22OC0075033"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"accepted":{"date-parts":[[2024,10,5]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Global Burden of Disease Study (GBD) produces prevalence estimates for \u2018idiopathic epilepsy\u2019 (ie, of unknown aetiology) and \u2018secondary epilepsy\u2019 (ie, with known aetiology) but does not report prevalence by underlying aetiologies for \u2018secondary epilepsy\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used nationwide, population-based register data from Denmark to identify underlying causes of epilepsy and their contribution to prevalence of \u2018secondary epilepsy\u2019 and compared with global prevalence data from GBD 2019. We identified all persons with a hospital-based epilepsy diagnosis and a filled prescription for antiseizure medication between 1 January 2009 and 31 December 2018. Epilepsy was categorised into \u2018idiopathic\u2019 or \u2018secondary\u2019 and \u2018total epilepsy\u2019 as the sum of the two epilepsy categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On 31 December 2018, a total of 5\u2009784\u2009284 individuals (49.7% males) were living in Denmark including 40\u2009336 with epilepsy (51.5% males). Perinatal conditions, traumatic brain injury, brain tumours and stroke were prominent underlying causes of \u2018secondary epilepsy\u2019. The prevalence of \u2018total epilepsy\u2019 in Denmark was 697 (95% CI 691 to 704) per 100 000 population (264 (95% CI 260 to 269) for \u2018secondary epilepsy\u2019 and 433 (95% CI 428 to 438) for \u2018idiopathic epilepsy\u2019). In the GBD 2019 Study, the prevalence of \u2018total epilepsy\u2019 in 2018 was 682 (95% uncertainty interval (UI) 586 to 784) per 100 000 population (359 (95% UI 324\u2013397) for \u2018secondary epilepsy\u2019 and 324 (95% UI 249 to 404) for \u2018idiopathic epilepsy\u2019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prevalence estimates of \u2018total epilepsy\u2019, \u2018idiopathic epilepsy\u2019 and \u2018secondary epilepsy\u2019 in Denmark align with the GBD 2019 estimates. In future studies, it is suggested to explicitly include all types of epilepsy, including \u2018secondary epilepsy\u2019, which is currently estimated as sequelae (consequences) of underlying diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jnnp-2024-334547","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T13:15:15Z","timestamp":1731417315000},"page":"480-488","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence of epilepsy: a population-based cohort study in Denmark with comparison to Global Burden of Disease (GBD) prevalence estimates"],"prefix":"10.1136","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-6435","authenticated-orcid":false,"given":"Jakob","family":"Christensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina B","family":"Trabjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Churl-Su","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari Modalsli","family":"Aaberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1061-9099","authenticated-orcid":false,"given":"Samuel","family":"Wiebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith Helen","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kon Magne","family":"Vegrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie","family":"Steinmetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Werenberg","family":"Dreier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"2025041009251778000_96.5.480.1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12550"},{"key":"2025041009251778000_96.5.480.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30454-X"},{"key":"2025041009251778000_96.5.480.3","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13709"},{"key":"2025041009251778000_96.5.480.4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac042"},{"key":"2025041009251778000_96.5.480.5","doi-asserted-by":"crossref","unstructured":"Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. 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