{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T18:10:45Z","timestamp":1778091045311,"version":"3.51.4"},"reference-count":39,"publisher":"BMJ","funder":[{"name":"MSfellows I Multiple Sclerosis Fellowships of the Walter und llse Rose-Stiftung","award":["T0298\/38958\/2021"],"award-info":[{"award-number":["T0298\/38958\/2021"]}]},{"DOI":"10.13039\/501100003493","name":"Gemeinn\u00fctzige Hertie-Stiftung","doi-asserted-by":"publisher","award":["P1200012"],"award-info":[{"award-number":["P1200012"]}],"id":[{"id":"10.13039\/501100003493","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003493","name":"Gemeinn\u00fctzige Hertie-Stiftung","doi-asserted-by":"publisher","award":["P1250014"],"award-info":[{"award-number":["P1250014"]}],"id":[{"id":"10.13039\/501100003493","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Germany iSTAR","award":["01EO2106"],"award-info":[{"award-number":["01EO2106"]}]},{"name":"Edda and Helmut Laich Foundation","award":["Z0798\/159"],"award-info":[{"award-number":["Z0798\/159"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Neurol Neurosurg Psychiatry"],"accepted":{"date-parts":[[2026,4,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autologous haematopoietic stem cell transplantation (aHSCT) represents a treatment option for highly aggressive multiple sclerosis (MS). Here, we report outcome analyses from the two largest German centres performing aHSCT in MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective analysis, people with (pw) MS who underwent aHSCT between 2007 and 2025 were included. Outcomes comprise no evidence of disease activity (NEDA-3), 3-month confirmed disability changes on the Expanded Disability Status Scale and transplantation-related mortality (TRM). Predictors of treatment response were evaluated according to the European Committee for Treatment and Research in Multiple Sclerosis and the European Society of Blood and Marrow Transplantation consensus criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 109 pwMS were included: 55 (50.5%) with relapsing-remitting MS (RRMS), 23 (21.1%) with secondary progressive MS (SPMS) and 31 (28.4%) with primary progressive MS (PPMS). Median follow-up after aHSCT was 20.1 months. Overall, 82.8% (SE 4.9%) of pwMS maintained NEDA-3. PwRRMS had significantly higher NEDA-3 rates (Kaplan-Meier (KM) estimate 91%, SE 5%) than those with SPMS (KM 80.1%, SE 10.5%, p=0.018) or PPMS (KM 70.6%, SE 11.4%, p=0.035). Patients meeting core consensus criteria achieved NEDA-3 more often (KM 94.4%, SE 5.4%) than those meeting the extended criteria (KM 84.4%, SE 8.5%, p=0.199) or those outside the criteria (KM 73.7%, SE 8.8%, p=0.004). In progressive MS, a disease duration of &lt;5 years indicated a potential prediction of NEDA-3 stability. TRM was 0.9% (n=1\/109).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this heterogeneous cohort, comprising a substantial proportion of people with progressive MS, aHSCT provided sustained NEDA-3 stability and a marked reduction in inflammatory disease activity, particularly in RRMS, with a potential benefit in progressive MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jnnp-2025-338129","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:20:17Z","timestamp":1778088017000},"page":"jnnp-2025-338129","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Autologous haematopoietic stem cell transplantation in multiple sclerosis: outcomes and predictors from German real-world data"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0371-2669","authenticated-orcid":false,"given":"Felix","family":"Fischbach","sequence":"first","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Korporal-Kuhnke","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena K","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Starke","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-7391","authenticated-orcid":false,"given":"Vivien","family":"H\u00e4u\u00dfler","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Braun","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Keller","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yekta","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarethe","family":"Daumen","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Lange","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"},{"name":"Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, HH, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Stockmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Fehse","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5228-4266","authenticated-orcid":false,"given":"Sina Cath\u00e9rine C","family":"Rosenkranz","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5347-7441","authenticated-orcid":false,"given":"Tim","family":"Friede","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-2420","authenticated-orcid":false,"given":"Manuel Alexander","family":"Friese","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Blank","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Ayuk","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Wildemann","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-9467","authenticated-orcid":false,"given":"Christoph","family":"Heesen","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf Center for Molecular Neurobiology Hamburg, Hamburg, Germany"},{"name":"Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"2026050610201199000_jnnp-2025-338129v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01473-3"},{"key":"2026050610201199000_jnnp-2025-338129v1.2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000560"},{"key":"2026050610201199000_jnnp-2025-338129v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00556-y"},{"key":"2026050610201199000_jnnp-2025-338129v1.4","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1001\/jamaneurol.2023.3331","article-title":"Harmonizing Definitions for Progression Independent of Relapse Activity in Multiple Sclerosis: A Systematic Review","volume":"80","author":"M\u00fcller","year":"2023","journal-title":"JAMA Neurol"},{"key":"2026050610201199000_jnnp-2025-338129v1.5","doi-asserted-by":"crossref","unstructured":"Zhu C , Zhou Z , Kalincik T , et al . Persistent progression independent of relapse activity in multiple sclerosis. Brain Communications 2025;7. doi:10.1093\/braincomms\/fcaf306","DOI":"10.1093\/braincomms\/fcaf306"},{"key":"2026050610201199000_jnnp-2025-338129v1.6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac016"},{"key":"2026050610201199000_jnnp-2025-338129v1.7","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-014-0167-z"},{"key":"2026050610201199000_jnnp-2025-338129v1.8","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s40120-022-00389-x","article-title":"Autologous Hematopoietic Stem-Cell Transplantation in Multiple Sclerosis: A Systematic Review and Meta-Analysis","volume":"11","author":"Nabizadeh","year":"2022","journal-title":"Neurol Ther"},{"key":"2026050610201199000_jnnp-2025-338129v1.9","doi-asserted-by":"crossref","DOI":"10.1111\/ene.16427","article-title":"Exploring the therapeutic potential of autologous hematopoietic stem cell transplantation in progressive multiple sclerosis\u2014a systematic review","volume":"31","author":"Braun","year":"2024","journal-title":"Euro J of Neurology"},{"key":"2026050610201199000_jnnp-2025-338129v1.10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-62726-4","article-title":"Efficacy and safety of stem cell transplantation for multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Nawar","year":"2024","journal-title":"Sci Rep"},{"key":"2026050610201199000_jnnp-2025-338129v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.81"},{"key":"2026050610201199000_jnnp-2025-338129v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0684-0"},{"key":"2026050610201199000_jnnp-2025-338129v1.13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18743"},{"key":"2026050610201199000_jnnp-2025-338129v1.14","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001329"},{"key":"2026050610201199000_jnnp-2025-338129v1.15","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10820-2"},{"key":"2026050610201199000_jnnp-2025-338129v1.16","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2023-331864"},{"key":"2026050610201199000_jnnp-2025-338129v1.17","doi-asserted-by":"crossref","unstructured":"Muraro PA , Kazmi M , De Matteis E , et al . Real-world effectiveness of autologous haematopoietic stem cell transplantation for multiple sclerosis in the UK. J Neurol Neurosurg Psychiatry 2025;jnnp\u20132025. doi:10.1136\/jnnp-2025-336755","DOI":"10.1136\/jnnp-2025-336755"},{"key":"2026050610201199000_jnnp-2025-338129v1.18","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/acn3.51366","article-title":"aHSCT is superior to alemtuzumab in maintaining NEDA and improving cognition in multiple sclerosis","volume":"8","author":"H\u00e4u\u00dfler","year":"2021","journal-title":"Ann Clin Transl Neurol"},{"key":"2026050610201199000_jnnp-2025-338129v1.19","doi-asserted-by":"crossref","first-page":"105414","DOI":"10.1016\/j.msard.2023.105414","article-title":"Benefits of aHSCT over alemtuzumab in patients with multiple sclerosis besides disability and relapses: Sustained improvement in cognition and quality of life","volume":"82","author":"Braun","year":"2024","journal-title":"Mult Scler Relat Disord"},{"key":"2026050610201199000_jnnp-2025-338129v1.20","doi-asserted-by":"crossref","DOI":"10.1177\/17562864231180730","article-title":"Autologous haematopoietic stem cell transplantation for multiple sclerosis: a position paper and registry outline","volume":"16","author":"Bayas","year":"2023","journal-title":"Ther Adv Neurol Disord"},{"key":"2026050610201199000_jnnp-2025-338129v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.02.014"},{"key":"2026050610201199000_jnnp-2025-338129v1.22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/jamaneurol.2020.4025","article-title":"Autologous Hematopoietic Stem Cell Transplant in Multiple Sclerosis: Recommendations of the National Multiple Sclerosis Society","volume":"78","author":"Miller","year":"2021","journal-title":"JAMA Neurol"},{"key":"2026050610201199000_jnnp-2025-338129v1.23","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/s41409-021-01276-z","article-title":"Autologous hematopoietic stem cell transplantation in multiple sclerosis: a global approval and availability review","volume":"56","author":"Stathopoulos","year":"2021","journal-title":"Bone Marrow Transplant"},{"key":"2026050610201199000_jnnp-2025-338129v1.24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41582-024-01050-x","article-title":"Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder - recommendations from ECTRIMS and the EBMT","volume":"21","author":"Muraro","year":"2025","journal-title":"Nat Rev Neurol"},{"key":"2026050610201199000_jnnp-2025-338129v1.25","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1032"},{"key":"2026050610201199000_jnnp-2025-338129v1.26","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20703"},{"key":"2026050610201199000_jnnp-2025-338129v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"2026050610201199000_jnnp-2025-338129v1.28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41409-025-02730-y","article-title":"Comparison of anti-human T cell globulins on immune reconstitution and early infections after autologous transplant in patients with multiple sclerosis","volume":"61","author":"Richter","year":"2026","journal-title":"Bone Marrow Transplant"},{"key":"2026050610201199000_jnnp-2025-338129v1.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00337.x"},{"key":"2026050610201199000_jnnp-2025-338129v1.30","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1093\/brain\/awt281","article-title":"Sex as a determinant of relapse incidence and progressive course of multiple sclerosis","volume":"136","author":"Kalincik","year":"2013","journal-title":"Brain (Bacau)"},{"key":"2026050610201199000_jnnp-2025-338129v1.31","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-025-13224-8","article-title":"Long-term effectiveness and safety of ocrelizumab: a single-centre real-world study","volume":"272","author":"Zaccone","year":"2025","journal-title":"J Neurol"},{"key":"2026050610201199000_jnnp-2025-338129v1.32","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/bjh.20199","article-title":"Autologous haematopoietic stem cell transplantation for multiple sclerosis in the UK: A 20-year retrospective analysis of activity and haematological outcomes from the British Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT)","volume":"207","author":"Kazmi","year":"2025","journal-title":"Br J Haematol"},{"key":"2026050610201199000_jnnp-2025-338129v1.33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606468"},{"key":"2026050610201199000_jnnp-2025-338129v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30342-2"},{"key":"2026050610201199000_jnnp-2025-338129v1.35","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209886","article-title":"Anti-CD20 Therapies in Drug-Naive Patients With Primary Progressive Multiple Sclerosis","volume":"103","author":"Hay","year":"2024","journal-title":"Neurology (ECronicon)"},{"key":"2026050610201199000_jnnp-2025-338129v1.36","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/ana.27247","article-title":"Effectiveness of Autologous Hematopoietic Stem Cell Transplantation versus Alemtuzumab and Ocrelizumab in Relapsing Multiple Sclerosis: A Single Center Cohort Study","volume":"98","author":"Muraro","year":"2025","journal-title":"Ann Neurol"},{"key":"2026050610201199000_jnnp-2025-338129v1.37","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2024-335512"},{"key":"2026050610201199000_jnnp-2025-338129v1.38","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02397-x"},{"key":"2026050610201199000_jnnp-2025-338129v1.39","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/s41409-025-02715-x","article-title":"BEAM\/ATG or cyclophosphamide\/ATG as conditioning regimen in autologous haemopoietic stem cell transplantation for multiple sclerosis: a retrospective analysis of the EBMT autoimmune diseases working party","volume":"60","author":"Greco","year":"2025","journal-title":"Bone Marrow Transplant"}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp-2025-338129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T17:20:20Z","timestamp":1778088020000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp-2025-338129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":39,"alternative-id":["10.1136\/jnnp-2025-338129"],"URL":"https:\/\/doi.org\/10.1136\/jnnp-2025-338129","relation":{},"ISSN":["0022-3050","1468-330X"],"issn-type":[{"value":"0022-3050","type":"print"},{"value":"1468-330X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]}}}