{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:37:21Z","timestamp":1791333441034,"version":"4.3.1"},"reference-count":12,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pract Neurol"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>Whipple\u2019s disease of the brain is one of the most challenging neurological diagnoses. \u201cIs it Whipple\u2019s disease?\u201d is a frequent question, but rarely is the answer yes. The neurological manifestations do not help to distinguish primary from secondary Whipple\u2019s disease of the brain, and although MR brain scanning with gadolinium is mandatory, it can be normal and any abnormalities are non-specific. There must be a comprehensive search for multisystem involvement such as raised inflammatory markers, lymphadenopathy or malabsorption; biopsy of lymph node or duodenum may be necessary. PCR and DNA sequencing for<jats:italic>Tropheryma whipplei<\/jats:italic>on lymphocytes from blood and cerebrospinal fluid is essential. Treatment is as difficult as the diagnosis\u2014there are no randomised controlled trials.<\/jats:p>","DOI":"10.1136\/jnnp.2008.156836","type":"journal-article","created":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T19:46:46Z","timestamp":1221594406000},"page":"311-317","source":"Crossref","is-referenced-by-count":34,"title":["Diagnosis and management of Whipple\u2019s disease of the brain"],"prefix":"10.1136","volume":"8","author":[{"given":"P K","family":"Panegyres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,9,16]]},"reference":[{"key":"2024052910320542000_8.5.311.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12274-X"},{"key":"2024052910320542000_8.5.311.2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl081"},{"key":"2024052910320542000_8.5.311.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra062477"},{"key":"2024052910320542000_8.5.311.4","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0140-6736(03)13533-7","article-title":"Whipple\u2019s disease, genomics, and drug therapy.","volume":"361","author":"Cannon","year":"2003","journal-title":"Lancet"},{"key":"2024052910320542000_8.5.311.5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.747-752.2004"},{"key":"2024052910320542000_8.5.311.6","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm259"},{"key":"2024052910320542000_8.5.311.7","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/0016-5085(85)90012-5","article-title":"Antibiotic treatment and relapse in Whipple\u2019s disease. Long-term follow-up of 88 patients.","volume":"88","author":"Keinath","year":"1985","journal-title":"Gastroenterology"},{"key":"2024052910320542000_8.5.311.8","first-page":"899","article-title":"Long-term follow-up in cerebral Whipples disease.","volume":"8","author":"Schnider","year":"1996","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2024052910320542000_8.5.311.9","unstructured":"European network on Tropheryma whipplei infections. http:\/\/www.eurice.info\/typo3sites\/index.php?id\u200a=\u200a167 (accessed 12 April 2008)"},{"key":"2024052910320542000_8.5.311.10","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.3.561-583.2001"},{"key":"2024052910320542000_8.5.311.11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-11_Part_1-199812010-00006"},{"key":"2024052910320542000_8.5.311.12","doi-asserted-by":"publisher","DOI":"10.1086\/378073"}],"container-title":["Practical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp.2008.156836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T17:33:02Z","timestamp":1717003982000},"score":1,"resource":{"primary":{"URL":"https:\/\/pn.bmj.com\/lookup\/doi\/10.1136\/jnnp.2008.156836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,16]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,9,16]]},"published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1136\/jnnp.2008.156836"],"URL":"https:\/\/doi.org\/10.1136\/jnnp.2008.156836","relation":{},"ISSN":["1474-7758","1474-7766"],"issn-type":[{"value":"1474-7758","type":"print"},{"value":"1474-7766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,16]]}}}