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However, information from pregnancy registers consistently show valproate to be associated with the highest risk for major congenital malformations, and studies exploring cognitive and behavioural development of offspring also show that valproate has an adverse impact. This creates a significant headache when trying to choose the \u201cright\u201d drug for most women with a generalised epilepsy syndrome.<\/jats:p>","DOI":"10.1136\/jnnp.2009.187898","type":"journal-article","created":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T04:18:14Z","timestamp":1253247494000},"page":"268-277","source":"Crossref","is-referenced-by-count":8,"title":["Treating women with juvenile myoclonic epilepsy"],"prefix":"10.1136","volume":"9","author":[{"given":"John J","family":"Craig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,9,17]]},"reference":[{"key":"2024052910382172000_9.5.268.1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1586\/14737175.6.1.111","article-title":"Quality of life for patients with epilepsy is determined by more than seizure control: the role of psychosocial factors.","volume":"6","author":"Schachter","year":"2006","journal-title":"Exp Rev Neurother"},{"key":"2024052910382172000_9.5.268.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60461-9"},{"key":"2024052910382172000_9.5.268.3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1528-1157.1998.tb01186.x","article-title":"Pregnancies of women with epilepsy: a population-based study in Iceland.","volume":"39","author":"Olafsson","year":"1998","journal-title":"Epilepsia"},{"key":"2024052910382172000_9.5.268.4","unstructured":"De Swiet M . 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