{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:23:56Z","timestamp":1770481436445,"version":"3.49.0"},"reference-count":30,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"published-print":{"date-parts":[[1977,12,1]]},"DOI":"10.1136\/jnnp.40.12.1136","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T21:02:42Z","timestamp":1226350962000},"page":"1136-1141","source":"Crossref","is-referenced-by-count":39,"title":["CSF studies on the relationship between dopamine and 5-hydroxytryptamine in Parkinsonism and other movement disorders."],"prefix":"10.1136","volume":"40","author":[{"given":"D L","family":"Davidson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C M","family":"Yates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Mawdsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I A","family":"Pullar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1007\/BF01487648","article-title":"Verteilung des 5-hydroxy tryptamins (serotonin) im gehirn des menschen und sein verhalten bei patienten mit Parkinsonsyndrom","volume":"39","year":"1961","unstructured":"Bernheimer, H., Birkmayer, W., and Hornykiewicz, 0. (1961). Verteilung des 5-hydroxy tryptamins (serotonin) im gehirn des menschen und sein verhalten bei patienten mit Parkinsonsyndrom. Klinische Wochenschrifte, 39, 1056-1059.","journal-title":"Klinische Wochenschrifte"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0022-510X(73)90175-5","article-title":"Brain dopamine and the syndrome of Parkinson and Huntington. Clinical morphological and neurochemical correlations","volume":"20","author":"Bernheimer, H.; Birkmayer, W.; O., Hornykiewicz; Jellinger, K.; Seitelberger, F.","year":"1973","unstructured":"Bernheimer, H., Birkmayer, W., Hornykiewicz. O., Jellinger, K., and Seitelberger, F. (1973). Brain dopamine and the syndrome of Parkinson and Huntington. Clinical morphological and neurochemical correlations. Journal of the Neurological Sciences, 20, 415-455.","journal-title":"Journal of the Neurological Sciences"},{"key":"ref_3","first-page":"\"101","article-title":"Clinical measurements of central dopamine and 5-hydroxytryptamine metabolism: reliability and interpretation of cerebrospinal fluid acid monoamine metabolite measures","volume":"11","author":"Bowers, M.B.","year":"1972","unstructured":"Bowers, M. B. (1972). Clinical measurements of central dopamine and 5-hydroxytryptamine metabolism: reliability and interpretation of cerebrospinal fluid acid monoamine metabolite measures. Neuropharmacology, 11, 101-111. Butcher, L., Engel, J., and Fuxe, K. (1970). L-dopa induced changes in central monoamine neurons after peripheral decarboxylase inhibition. Journal of Pharmacy and Pharmacology, 22, 313-316.","journal-title":"Neuropharmacology; L-dopa induced changes in central monoamine neurons after peripheral decarboxylase inhibition"},{"key":"ref_4","first-page":"1029","article-title":"5-Hydroxytryptophan in Parkinsonism","volume":"1","author":"Chase, T.N.","year":"1970","unstructured":"Chase, T. N. (1970). 5-Hydroxytryptophan in Parkinsonism. Lancet, 1, 1029-1030. Chase. T. (1974). Serotonergic-dopaminergic interactions and extrapyramidal function. In Advances","journal-title":"Lancet; Advances; Serotonergic-dopaminergic interactions and extrapyramidal function"},{"key":"ref_5","author":"Chase, T.N.; Gordon, E.K.; Ng, L.K.Y.","year":"1973","unstructured":"Chase, T. N., Gordon, E. K., and Ng, L. K. Y. (1973)."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1471-4159.1973.tb06003.x","article-title":"Norepinephrine metabolism in the central nervous system of man: studies using 3-methoxy-4-hydroxyphenylethylene glycol levels in cerebrospinal fluid","volume":"21","unstructured":"Norepinephrine metabolism in the central nervous system of man: studies using 3-methoxy-4-hydroxyphenylethylene glycol levels in cerebrospinal fluid. Journal of Neurochemistry, 21, 581-587.","journal-title":"Journal of Neurochemistry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0140-6736(71)90587-3","article-title":"Probenecid test in Parkinson's disease","volume":"2","author":"Chase, T.; Ng, L.K.Y.","year":"1971","unstructured":"Chase, T., and Ng, L. K. Y. (1971). Probenecid test in Parkinson's disease. Lancet, 2, 1265-1266.","journal-title":"Lancet"},{"key":"ref_8","first-page":"479","article-title":"Central monamine metabolism in Parkinson's disease","volume":"22","author":"Chase, T.; Ng, L.K.Y.","year":"1972","unstructured":"Chase, T., and Ng, L. K. Y. (1972). Central monamine metabolism in Parkinson's disease. Archives of Neurology (Chicago), 22, 479-484.","journal-title":"Archives of Neurology (Chicago)"},{"key":"ref_9","first-page":"66","article-title":"The nucleus linearis intermedius raphe and behavior evoked by direct and indirect stimulation of dopamine sensitive sites within the caudate nucleus of cats","volume":"28","author":"Cools, A.R.; Janssen, H.-J.","year":"1974","unstructured":"Cools, A. R., and Janssen, H-J. (1974). The nucleus linearis intermedius raphe and behavior evoked by direct and indirect stimulation of dopamine sensitive sites within the caudate nucleus of cats. Journal of Neurochemistry, 28, 66-275.","journal-title":"Journal of Neurochemistry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/jnnp.40.8.741","article-title":"Monoamine metabolites in cerebrospinal fluid in multiple sclerosis","volume":"40","author":"Davidson, D.W.; Pullar, I.A.; Mawdsley, C.; Kinloch, N.; Yates, C.M.","year":"1977","unstructured":"Davidson, D. W., Pullar, I. A., Mawdsley, C., Kinloch, N., and Yates, C. M. (1977). Monoamine metabolites in cerebrospinal fluid in multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry, 40, 741-745.","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/BF01485901","article-title":"Verteilung von noradrenalin und dopamin (3-hydroxytyramin) im gehirn des menschen und ihr verhalten bei erkrankungen des extrapyramidalen systems","volume":"38","author":"Ehringer, H.; Hornykiewicz, 0","year":"1960","unstructured":"Ehringer, H., and Hornykiewicz, 0. (1960). Verteilung von noradrenalin und dopamin (3-hydroxytyramin) im gehirn des menschen und ihr verhalten bei erkrankungen des extrapyramidalen systems. Klinische Wochenschrifte, 38, 1236-1239.","journal-title":"Klinische Wochenschrifte"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/jnnp.34.3.219","article-title":"Comparison of benefit of L-dopa in Parkinsonism with increase of amine metabolites in the CSF","volume":"34","author":"Godwin-Austen, R.B.; Kantamaneni, B.D.; Curzon, G.","year":"1971","unstructured":"Godwin-Austen, R. B., Kantamaneni, B. D., and Curzon, G. (1971). Comparison of benefit of L-dopa in Parkinsonism with increase of amine metabolites in the CSF. Journal of Neurology, Neurosurgery, and Psychiatry, 34, 219-223.","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0028-3908(71)90081-5","article-title":"Age monoamine metabolites in human CSF and their relations to age and sex","volume":"10","author":"Gottfries, C.G.; Gottfries, I.; Johansson, B.; Olsson, R.; Persson, T.; Roos, B.-E.; Sj6strom, R.","year":"1971","unstructured":"Gottfries, C. G., Gottfries, I., Johansson, B., Olsson, R., Persson, T., Roos, B-E.. and Sj6strom, R. (1971). Age monoamine metabolites in human CSF and their relations to age and sex. Neuropharmacology, 10, 665-672.","journal-title":"Neuropharmacology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00561323","article-title":"Relationship of age and mood to monoamine metabolites in cerebrospinal fluid in Parkinsonism","volume":"7","author":"Granerus, A.K.; Magnusson, T.; Roos, B.-E.; Svanborg, A.","year":"1974","unstructured":"Granerus, A. K., Magnusson, T., Roos, B-E., and Svanborg, A. (1974). Relationship of age and mood to monoamine metabolites in cerebrospinal fluid in Parkinsonism. European Journal of Clinical Pharmacology, 7, 105-109.","journal-title":"European Journal of Clinical Pharmacology"},{"key":"ref_15","first-page":"457","article-title":"Some studies of the effects of chlorpromazine, reserpine and dihydroxyphenylalanine on the concentrations of homovanillic acid, 3, 4-dihydroxyphenylacetic acid and 5-hydroxyindol-3-ylacetic acid in ventricular cerebrospinal fluid of the dog using the techniques of serial sampling of the cerebrospinal fluid","volume":"33","author":"Guldberg, H.C.; Yates, C.M.","year":"1968","unstructured":"Guldberg, H. C., and Yates, C. M. (1968). Some studies of the effects of chlorpromazine, reserpine and dihydroxyphenylalanine on the concentrations of homovanillic acid, 3, 4-dihydroxyphenylacetic acid and 5-hydroxyindol-3-ylacetic acid in ventricular cerebrospinal fluid of the dog using the techniques of serial sampling of the cerebrospinal fluid. British Journal of Pharmacology, 33, 457-471.","journal-title":"British Journal of Pharmacology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-510X(73)90050-6","article-title":"Amine metabolites in the cerebrospinal fluid in Parkinson's disease and the response to levodopa","volume":"19","author":"Gumpert, J.; Sharpe, D.; Curzon, G.","year":"1973","unstructured":"Gumpert, J., Sharpe, D., and Curzon, G. (1973). Amine metabolites in the cerebrospinal fluid in Parkinson's disease and the response to levodopa. Journal of the Neurological Sciences, 19, 1-12.","journal-title":"Journal of the Neurological Sciences"},{"key":"ref_17","article-title":"Non-homogeneous distribution of 5-","author":"Jakupcevid, M.; Lackovid, Stefoski; D.; Bulat, M.","year":"1977","unstructured":"Jakupcevid, M., Lackovid, Stefoski, D., and Bulat, M. (1977). Non-homogeneous distribution of 5-"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0022-510X(77)90103-4","article-title":"hydroxyindolylacetic acid and homovanillic acid in the lumbar CSF of man","volume":"31","unstructured":"hydroxyindolylacetic acid and homovanillic acid in the lumbar CSF of man. Journal of the Neurological Sciences, 31, 165-171.","journal-title":"Journal of the Neurological Sciences"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1212\/WNL.22.1.15","article-title":"Biochemical investigations in patients with Parkinson's disease treated with L-dopa","volume":"22","author":"Jequier, E.; Dufresne, J.-J.","year":"1972","unstructured":"Jequier, E., and Dufresne, J-J. (1972). Biochemical investigations in patients with Parkinson's disease treated with L-dopa. Neurology (Minneapolis), 22, 15-21.","journal-title":"Neurology (Minneapolis)"},{"key":"ref_20","series-title":"Proceedings of the 8th International Congress of Neurology","first-page":"141","article-title":"Acid metabolites in the cerebrospinal fluid of patients with Parkinson's syndrome","author":"Johansson, B.; Roos, B.-E.","year":"1965","unstructured":"Johansson, B., and Roos, B-E. (1965). Acid metabolites in the cerebrospinal fluid of patients with Parkinson's syndrome. Proceedings of the 8th International Congress of Neurology, Vienna, IV\/I, 141-144."},{"key":"ref_21","article-title":"5-Hydroxyindole acetic acid and homovanillic acid in cerebrospinal fluid of patients with neurological diseases","author":"Johansson, B.; Roos, B.-E.","year":"1974","unstructured":"Johansson, B., and Roos, B-E. (1974). 5-Hydroxyindole acetic acid and homovanillic acid in cerebrospinal fluid of patients with neurological diseases."},{"key":"ref_22","first-page":"164","article-title":"Predicting response to levodopa","volume":"2","author":"Lakke, J.P.W.F.; Korf, J.; Van Praag, H.M.","year":"1971","unstructured":"Lakke, J. P. W. F., Korf, J., and Van Praag, H. M. (1971). Predicting response to levodopa. Lancet, 2, 164-165.","journal-title":"Lancet"},{"key":"ref_23","first-page":"1083","article-title":"Treatment of Parkinson's disease with amantadine and levodopa","volume":"1","author":"Parkes, J.D.; Baxter, R.C.H.; Curzon, G.; Knill-Jones, R.P.; Knott, P.J.; Marsden, C.D.; Tattersall, R.; Vollum, D.","year":"1971","unstructured":"Parkes, J. D., Baxter, R. C. H., Curzon, G., Knill-Jones, R. P., Knott, P. J., Marsden, C. D., Tattersall, R., and Vollum, D. (1971). Treatment of Parkinson's disease with amantadine and levodopa. Lancet, 1, 1083-1086.","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1176\/ajp.130.1.67","article-title":"Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness","volume":"130","author":"Post, R.M.; Kotin, J.; Godwin, F.K.; Gordon, E.K.","year":"1973","unstructured":"Post, R. M., Kotin, J., Godwin, F. K., and Gordon, E. K. (1973). Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness. American Journal of Psychiatry, 130, 67-72.","journal-title":"American Journal of Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/jnnp.33.6.851","article-title":"Phenolic acid concentrations in the lumbar cerebrospinal fluid of Parkinsonian patients treated with 1-dopa","volume":"33","author":"Pullar, I.A.; Weddell, J.M.; Ahmed, R.; Gillingham, F.J.","year":"1970","unstructured":"Pullar, I. A., Weddell, J. M., Ahmed, R., and Gillingham, F. J. (1970). Phenolic acid concentrations in the lumbar cerebrospinal fluid of Parkinsonian patients treated with 1-dopa. Journal of Neurology, Neurosurgery, and Psychiatry, 33, 851-857.","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000114243","article-title":"Acid monoamine metabolites in the cerebrospinal fluid of Parkinsonian patients treated with levodopa alone or combined with a decarboxylase inhibitor","volume":"9","author":"Rinne, U.K.; Sonninen, V.; Siirtola, T.","year":"1973","unstructured":"Rinne, U. K., Sonninen, V., and Siirtola, T. (1973). Acid monoamine metabolites in the cerebrospinal fluid of Parkinsonian patients treated with levodopa alone or combined with a decarboxylase inhibitor. European Neurology, 9, 349-362.","journal-title":"European Neurology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF01895555","article-title":"The effect of L-dopa on monoamine metabolites in Parkinson's disease","volume":"26","author":"Van Woert, M.H.; Bowers, M.B.","year":"1970","unstructured":"Van Woert, M. H., and Bowers, M. B. (1970). The effect of L-dopa on monoamine metabolites in Parkinson's disease. Experientia (Basel), 26, 161-163.","journal-title":"Experientia (Basel)"},{"key":"ref_28","first-page":"747752","article-title":"Failure of cerebrospinal fluid homovanillic acid to predict levodopa response in Parkinson's disease","volume":"36","author":"Weiner, W.J.; Klawans, H.L.","year":"1973","unstructured":"Weiner, W. J., and Klawans, H. L. (1973). Failure of cerebrospinal fluid homovanillic acid to predict levodopa response in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 36, 747752.","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"ref_29","series-title":"Metabolism of biogenic amines in the CNS of man. In Proceedings of the Sixth International Congress of Pharmacology","first-page":"245","volume":"3","author":"Wilk, S.","year":"1976","unstructured":"Wilk, S. (1976). Metabolism of biogenic amines in the CNS of man. In Proceedings of the Sixth International Congress of Pharmacology. Edited by J. Tuomisto and M. K. Paasonen, Vol. 3, pp. 245-254. Pergamon Press: Oxford."},{"key":"ref_30","first-page":"781784","article-title":"Clearance of 3-methoxy-4-hydroxyphenylglycol from the cerebrospinal fluid","volume":"26","author":"Wolfson, L.I.; Escriva, A.","year":"1976","unstructured":"Wolfson, L. I., and Escriva, A. (1976). Clearance of 3-methoxy-4-hydroxyphenylglycol from the cerebrospinal fluid. Neurology (Minneapolis), 26, 781784.","journal-title":"Neurology (Minneapolis)"}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp.40.12.1136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T02:38:49Z","timestamp":1601087929000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp.40.12.1136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,12,1]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1977,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/jnnp.40.12.1136","relation":{},"ISSN":["0022-3050"],"issn-type":[{"value":"0022-3050","type":"print"}],"subject":[],"published":{"date-parts":[[1977,12,1]]}}}