{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:40:36Z","timestamp":1768970436980,"version":"3.49.0"},"reference-count":30,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"published-print":{"date-parts":[[1979,10,1]]},"DOI":"10.1136\/jnnp.42.10.904","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T21:02:42Z","timestamp":1226350962000},"page":"904-909","source":"Crossref","is-referenced-by-count":88,"title":["beta-Adrenoreceptor antagonists in essential tremor."],"prefix":"10.1136","volume":"42","author":[{"given":"D","family":"Jefferson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Jenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C D","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"340","article-title":"A new type of cardioselective adrenoceptive blocking drug","volume":"48","author":"Barrett, A.M.; Carter, J.; Fitzgerald, J.D.; Hull, R.; Le Count, D.","year":"1973","unstructured":"Barrett, A. M., Carter, J., Fitzgerald, J. D., Hull, R., and Le Count, D. (1973). A new type of cardioselective adrenoceptive blocking drug. British Journal of Pharmacology, 48, 340P.","journal-title":"British Journal of Pharmacology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1113\/jphysiol.1958.sp006088","article-title":"The effects of adrenaline, noradrenaline and isoprenaline on skeletal muscle contractions in the cat","volume":"144","author":"Bowman, W.C.; Zaimis, E.","year":"1958","unstructured":"Bowman, W. C., and Zaimis, E. (1958). The effects of adrenaline, noradrenaline and isoprenaline on skeletal muscle contractions in the cat. Journal of Physiology (London), 144, 92-107.","journal-title":"Journal of Physiology (London)"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1476-5381.1970.tb10334.x","article-title":"Actions of some sympathomimetic bronchodilator and betaadrenoceptor blocking drugs on contractions of the cat soleus muscle","volume":"38","author":"Bowman, W.C.; Nott, M.W.","year":"1970","unstructured":"Bowman, W. C., and Nott, M. W. (1970). Actions of some sympathomimetic bronchodilator and betaadrenoceptor blocking drugs on contractions of the cat soleus muscle. British Journal of Pharmacology, 38, 37-49.","journal-title":"British Journal of Pharmacology"},{"key":"ref_4","article-title":"The selective action of p-adrenoreceptor blocking drugs and the nature of f13 and 82 adrenoceptors","author":"Coleman, A.J.; Somerville, A.R.","year":"1977","unstructured":"Coleman, A. J., and Somerville, A. R. (1977). The selective action of p-adrenoreceptor blocking drugs and the nature of f13 and 82 adrenoceptors."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1476-5381.1977.tb06980.x","volume":"59","unstructured":"British Journal of Pharmacology, 59, 83-93.","journal-title":"British Journal of Pharmacology"},{"key":"ref_6","article-title":"The effect of propranolol on the human and canine transmembrane action potential","volume":"40","author":"Coltart, D.J.; Meldrum, S.J.","year":"1970","unstructured":"Coltart, D. J., and Meldrum, S. J. (1970). The effect of propranolol on the human and canine transmembrane action potential. British Journal of Pharmacology, 40, 148P. Coltart, D. J., and Shand, D. G. (1970). Plasma propranolol levels in the quantitative assessment of","journal-title":"British Journal of Pharmacology; Plasma propranolol levels in the quantitative assessment of"},{"key":"ref_7","first-page":"731","article-title":"f-adrenergic blockade in man","volume":"3","unstructured":",f-adrenergic blockade in man. British Medical Journal, 3, 731-734.","journal-title":"British Medical Journal"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2125.1976.tb00602.x","article-title":"Human pharmacokinetic and pharmacodynamic studies on atenolol (CI 66,082), a new cardioselective \/3adrenoceptor blocking drug","volume":"3","author":"Conway, F.J.; Fitzgerald, J.D.; McAinsh, J.; Rowlands, D.J.; Simpson, W.T.","year":"1976","unstructured":"Conway, F. J., Fitzgerald, J. D., McAinsh, J., Rowlands, D. J., and Simpson, W. T. (1976). Human pharmacokinetic and pharmacodynamic studies on atenolol (CI 66,082), a new cardioselective \/3adrenoceptor blocking drug. British Journal of Clinical Pharmacology, 3, 267-272.","journal-title":"British Journal of Clinical Pharmacology"},{"key":"ref_9","first-page":"184","article-title":"The central uptake of \/8-adrenoceptor antagonists","volume":"29","author":"Day, M.D.; Hemsworth, B.A.; Street, J.A.","year":"1977","unstructured":"Day, M. D., Hemsworth, B. A., and Street, J. A. (1977). The central uptake of \/8-adrenoceptor antagonists. Journal of Pharmacy and Pharmacology, 29, Supplement, 52P. Decalmer, J. B. S., Chatterjee, S. S., Cruickshank, J. M., Benson, M. K., and Sterling, G. M. (1978). Beta-blockers and asthma. British Heart Journal, 40, 184-189.","journal-title":"Journal of Pharmacy and Pharmacology; Beta-blockers and asthma"},{"key":"ref_10","first-page":"201","article-title":"Selective blockade of adrenoreceptor beta-receptors in the heart","volume":"32","author":"Dunlop, D.; Shanks, B.G.","year":"1968","unstructured":"Dunlop, D., and Shanks, B. G. (1968). Selective blockade of adrenoreceptor beta-receptors in the heart. British Journal of Pharmacology, 32, 201-218.","journal-title":"British Journal of Pharmacology"},{"key":"ref_11","author":"Dupont, E.; Hansen, H.J.; Dalby, M.A.","year":"1973","unstructured":"Dupont, E., Hansen, H. J., and Dalby, M. A. (1973)."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0022-3565(25)30247-8","article-title":"Comparative antihypertensive effects and tissue distribution of ,\/-adrenergic blocking drugs","volume":"194","author":"Garvey, H.L.; Ram, N.","year":"1975","unstructured":"Garvey, H. L., and Ram, N. (1975). Comparative antihypertensive effects and tissue distribution of ,\/-adrenergic blocking drugs. Journal of Pharmacology and Experimental Therapeutics, 194, 220-233.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2165\/00003495-197407010-00002","article-title":"Pharmacodynamic properties of 8-adrenergic receptor blocking drugs in man","volume":"7","author":"Gibson, D.G.","year":"1974","unstructured":"Gibson, D. G. (1974). Pharmacodynamic properties of 8-adrenergic receptor blocking drugs in man. Drugs, 7, 8-38.","journal-title":"Drugs"},{"key":"ref_14","first-page":"\"98","article-title":"The effect of adrenaline on the response to muscle vibration in man","volume":"202","author":"Hodgson, H.J.F.; Marsden, C.D.; Meadows, J.C.","year":"1969","unstructured":"Hodgson, H. J. F., Marsden, C. D., and Meadows, J. C. (1969). The effect of adrenaline on the response to muscle vibration in man. Journal of Physiology (London), 202, 98-99P. Jefferson, D., Jenner, P., and Marsden, C. D. (1979). The relationship between plasma propranolol concentration and the relief of essential tremor. Journal of Neurology, Neurosurgery, and Psychiatry, 42, 831-837.","journal-title":"Journal of Physiology (London); The relationship between plasma propranolol concentration and the relief of essential tremor"},{"key":"ref_15","first-page":"53","article-title":"Peripheral adrenergic receptors concerned with tremor","volume":"33","author":"Marsden, C.D.; Foley, T.H.; Owen, D.A.L.; McAllister, R.G.","year":"1967","unstructured":"Marsden, C. D., Foley, T. H., Owen, D. A. L., and McAllister, R. G. (1967). Peripheral adrenergic receptors concerned with tremor. Clinical Science, 33, 53-65.","journal-title":"Clinical Science"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1113\/jphysiol.1970.sp009071","article-title":"The effect of adrenaline on the contraction of human muscle","volume":"207","author":"Marsden, C.D.; Meadows, J.C.","year":"1970","unstructured":"Marsden, C. D., and Meadows, J. C. (1970). The effect of adrenaline on the contraction of human muscle. Journal of Physiology (London), 207, 429-448.","journal-title":"Journal of Physiology (London)"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ana.410010210","article-title":"Suppression of essential tremor by propranolol: correlation of effect with drug plasma level and intensity of beta-adrenergic blockade","volume":"1","author":"McAllister, R.G.; Markesbery, W.R.; Ware, R.W.; Howell, M.A.","year":"1977","unstructured":"McAllister, R. G., Markesbery, W. R., Ware, R. W., and Howell, M. A. (1977). Suppression of essential tremor by propranolol: correlation of effect with drug plasma level and intensity of beta-adrenergic blockade. Annals of Neurology, 1, 160-166.","journal-title":"Annals of Neurology"},{"key":"ref_18","first-page":"332","article-title":"The effects on cardiac muscle of betareceptor antagonists in relation to their activity as local anaesthetics","volume":"24","author":"Morales-Aguilera, A.; Vaughan Williams, E.M.","year":"1965","unstructured":"Morales-Aguilera, A., and Vaughan Williams, E. M. (1965). The effects on cardiac muscle of betareceptor antagonists in relation to their activity as local anaesthetics. British Journal of Pharmacology, 24, 332-333.","journal-title":"British Journal of Pharmacology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/jnnp.36.4.618","article-title":"Effect of the beta adrenergic blocking agent propranolol on essential tremor","volume":"36","author":"Morgan, M.H.; Hewer, R.L.; Cooper, R.","year":"1973","unstructured":"Morgan, M. H., Hewer, R. L., and Cooper, R. (1973). Effect of the beta adrenergic blocking agent propranolol on essential tremor. Journal of Neurology, Neurosurgery, and Psychiatry, 36, 618-624.","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0022-3565(25)30067-4","article-title":"Brain concentration of propranolol in relation to hypotensive effect in the rabbit with observations on brain propranolol levels in man","volume":"192","author":"Myers, M.G.; Lewis, P.J.; Reid, J.L.; Dollery, C.T.","year":"1975","unstructured":"Myers, M. G., Lewis, P. J., Reid, J. L., and Dollery, C. T. (1975). Brain concentration of propranolol in relation to hypotensive effect in the rabbit with observations on brain propranolol levels in man. Journal of Pharmacology and Experimental Therapeutics, 192, 327-335.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"ref_21","first-page":"62","article-title":"Treatment of benign essential tremor with a beta-adrenergic blocking agent (sotalol)","volume":"341","author":"Rangel-Guerra, R.","year":"1974","unstructured":"Rangel-Guerra, R. (1974). Treatment of benign essential tremor with a beta-adrenergic blocking agent (sotalol). Excerpta Medica, 341, 62-66.","journal-title":"Excerpta Medica"},{"key":"ref_22","first-page":"56","article-title":"Sotalol in the treatment of essential tremor","volume":"341","author":"Rinne, U.K.; Kaitaniemi, P.","year":"1974","unstructured":"Rinne, U. K., and Kaitaniemi, P. (1974). Sotalol in the treatment of essential tremor. Excerpta Medica, 341, 56-61.","journal-title":"Excerpta Medica"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0014-2999(75)90227-7","article-title":"A comparison of the actions of ICI 66,082 and propranolol on cardiac and peripheral beta-adrenoreceptors","volume":"34","author":"Singh, B.N.; Nisbet, H.D.; Harris, E.A.; Whitlock, R.M.","year":"1975","unstructured":"Singh, B. N., Nisbet, H. D., Harris, E. A., and Whitlock, R. M. (1975). A comparison of the actions of ICI 66,082 and propranolol on cardiac and peripheral beta-adrenoreceptors. European Journal of Pharmacology, 34, 75-86.","journal-title":"European Journal of Pharmacology"},{"key":"ref_24","first-page":"172","article-title":"Cardiovascular pharmacology of two new beta adrenergic receptor antagonists","volume":"149","author":"Stanton, H.C.; Kirchgessnes, T.; Parmenter, K.","year":"1965","unstructured":"Stanton, H. C., Kirchgessnes, T., and Parmenter, K. (1965). Cardiovascular pharmacology of two new beta adrenergic receptor antagonists. Journal of Pharmacology and Experimental Therapeutics, 149, 172-182.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2125.1978.tb04618.x","article-title":"CSF\/plasma ratios of propranolol in man","volume":"6","author":"Taylor, E.A.; Carroll, D.; Turner, P.","year":"1978","unstructured":"Taylor, E. A., Carroll, D., and Turner, P. (1978). CSF\/plasma ratios of propranolol in man. British Journal of Clinical Pharmacology, 6, 447P.","journal-title":"British Journal of Clinical Pharmacology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1212\/WNL.27.5.439","article-title":"Comparison between the effects of pindolol and propranolol on essential tremor","volume":"27","author":"Teravainen, M.D.; Larsen, A.; Fogelholm, M.D.","year":"1977","unstructured":"Teravainen, M. D., Larsen, A., and Fogelholm, M. D. (1977). Comparison between the effects of pindolol and propranolol on essential tremor. Neurology (Minneapolis), 27, 439-442.","journal-title":"Neurology (Minneapolis)"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1212\/WNL.25.11.1041","article-title":"Essential tremor: treatment with propranolol","volume":"24","author":"Tolosa, E.S.; Loewenson, R.B.","year":"1975","unstructured":"Tolosa, E. S., and Loewenson, R. B. (1975). Essential tremor: treatment with propranolol. Neurology (Minneapolis), 24, 1041-1044.","journal-title":"Neurology (Minneapolis)"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/bmj.2.6033.453","article-title":"The effect of atenolol on ventilatory and cardiac function in asthma","volume":"2","author":"Vilsvik, J.S.; Schaanning, J.","year":"1976","unstructured":"Vilsvik, J. S., and Schaanning, J. (1976). The effect of atenolol on ventilatory and cardiac function in asthma. British Medical Journal, 2, 453-455.","journal-title":"British Medical Journal"},{"key":"ref_29","first-page":"66","article-title":"The control of essential tremor by propranolol","volume":"96","author":"Winkler, G.F.; Young, R.R.","year":"1971","unstructured":"Winkler, G. F., and Young, R. R. (1971). The control of essential tremor by propranolol. Transactions of the American Neurological Association, 96, 66-68.","journal-title":"Transactions of the American Neurological Association"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1056\/NEJM197511062931902","article-title":"Beta-adrenergic mechanisms in action tremor","volume":"293","author":"Young, R.R.; Growdon, J.H.; Shahani, B.T.","year":"1975","unstructured":"Young, R. R., Growdon, J. H., and Shahani, B. T. (1975). Beta-adrenergic mechanisms in action tremor. New England Journal of Medicine, 293, 950-953.","journal-title":"New England Journal of Medicine"}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp.42.10.904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T16:42:10Z","timestamp":1738514530000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp.42.10.904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,10,1]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1979,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/jnnp.42.10.904","relation":{},"ISSN":["0022-3050"],"issn-type":[{"value":"0022-3050","type":"print"}],"subject":[],"published":{"date-parts":[[1979,10,1]]}}}