{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:57:32Z","timestamp":1761807452876},"reference-count":26,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"published-print":{"date-parts":[[1981,9,1]]},"DOI":"10.1136\/jnnp.44.9.814","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T21:16:40Z","timestamp":1226351800000},"page":"814-819","source":"Crossref","is-referenced-by-count":48,"title":["Metoprolol and propranolol in essential tremor: a double-blind, controlled study."],"prefix":"10.1136","volume":"44","author":[{"given":"S","family":"Calzetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L J","family":"Findley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Gresty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Perucca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Richens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"809","volume-title":"Handbook of Clinical Neurology","volume":"6","author":"In, Marshall J.Tremor","year":"1968","unstructured":"Marshall J. Tremor. In: Vinken PJ, Bruyn GW, eds. Handbook of Clinical Neurology. Amsterdam: North-Holland 1968;6:809-25."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/brain\/72.2.113","article-title":"Observations on essential (heredofamilial) tremor","volume":"72","author":"Critchley, M.","year":"1949","unstructured":"Critchley M. Observations on essential (heredofamilial) tremor. Brain 1949;72:113-39.","journal-title":"Brain"},{"key":"ref_3","first-page":"129","article-title":"Action Tremors: a clinical neurophysiological review","volume-title":"Pathological Tremors and Clonus","volume":"5","author":"Shahani, B.T.; Young, R.R.","year":"1978","unstructured":"Shahani BT, Young RR. Action Tremors: a clinical neurophysiological review. In: Desmedt JE, ed. Physiological Tremor, Pathological Tremors and Clonus. Prog. Clin. Neurophysiol; Basel: Karger 1978;5:129-37."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1212\/WNL.25.3.259","article-title":"The effect of alcohol on essential tremor","volume":"25","author":"Growdon, J.H.; Shanani, B.T.; Young, R.R.","year":"1975","unstructured":"Growdon JH, Shanani BT, Young RR. The effect of alcohol on essential tremor. Neurology (Minneap) 1975; 25:259-62.","journal-title":"Neurology (Minneap)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1056\/NEJM197405022901802","article-title":"Efficacy of chronic Propranolol therapy in action tremors of the familial, senile or essential varieties","volume":"290","author":"Winkler, G.F.; Young, R.R.","year":"1974","unstructured":"Winkler GF, Young RR. Efficacy of chronic Propranolol therapy in action tremors of the familial, senile or essential varieties. N EngI J Med 1974;290:984-8.","journal-title":"N EngI J Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ana.410010210","article-title":"Suppression of essential tremor by Propranolol: correlation of effect with drug plasma levels and intensity of beta-adrenergic blockade","volume":"1","author":"RJ, Jr, McAllister; WR, Markesbery; RW, Ware; SM, Howell","year":"1977","unstructured":"McAllister RJ Jr, Markesbery WR, Ware RW, Howell SM. Suppression of essential tremor by Propranolol: correlation of effect with drug plasma levels and intensity of beta-adrenergic blockade. Ann Neurol 1977;1:160-6.","journal-title":"Ann Neurol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1212\/WNL.25.11.1041","article-title":"Essential tremor: treatment with Propranolol","volume":"25","author":"Tolosa, E.S.; RB, Loewenson","year":"1975","unstructured":"Tolosa, ES, Loewenson RB. Essential tremor: treatment with Propranolol. Neurology (Minneap) 1975; 25:1041-4.","journal-title":"Neurology (Minneap)"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/jnnp.36.4.618","article-title":"Effect of the beta adrenergic blocking agent, Propranolol, on essential tremor","volume":"36","author":"Morgan, M.H.; Hewer, R.L.; Cooper, R.","year":"1973","unstructured":"Morgan MH, Hewer RL, Cooper R. Effect of the beta adrenergic blocking agent, Propranolol, on essential tremor. J Neurol Neurosurg Psychiatry 1973;36: 618-24.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(80)90979-4","article-title":"Metoprolol in essential tremor","volume":"1","author":"Jefferson, D.; Marsden, C.D.","year":"1980","unstructured":"Jefferson D, Marsden CD. Metoprolol in essential tremor. Lancet 1980;1:427.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1056\/NEJM197511062931902","article-title":"Beta-adrenergic mechanisms in action tremor","volume":"293","author":"Young, R.R.; Growdon, J.H.; Shahani, B.T.","year":"1975","unstructured":"Young RR, Growdon JH, Shahani BT. Beta-adrenergic mechanisms in action tremor. N Eng J Med 1975; 293:950-3.","journal-title":"N Eng J Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0140-6736(80)91474-9","article-title":"Metoprolol in essential tremor","volume":"1","author":"0, Ljung","year":"1980","unstructured":"Ljung 0. Metoprolol in essential tremor. Lancet 1980; 1:1032.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"\"904","DOI":"10.1136\/jnnp.42.10.904","article-title":"Beta-adrenoceptor antagonists in essential tremor","volume":"42","author":"Jefferson, D.; Jenner, P.; Marsden, C.D.","year":"1979","unstructured":"Jefferson D, Jenner P, Marsden CD. Beta-adrenoceptor antagonists in essential tremor. J Neurol Neurosurg Psychiatry 1979;42:904-9. 1:1 Ljung 0. Treatment of essential tremor with Metoprolol. N Engl J Med 1979;301:1005.","journal-title":"J Neurol Neurosurg Psychiatry; 1 Ljung 0. Treatment of essential tremor with Metoprolol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1056\/NEJM197908093010617","article-title":"Metoprolol for essential tremor","volume":"301","author":"Britt, C.W.; Peters, B.H.","year":"1979","unstructured":"Britt CW, Peters BH. Metoprolol for essential tremor. N Engl J Med 1979;301:331.","journal-title":"N Engl J Med"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1056\/NEJM197909203011215","article-title":"Metoprolol tartrate for essential tremor","volume":"301","author":"Riley, R.; Fleet, A.B.","year":"1979","unstructured":"Riley R, Fleet AB. Metoprolol tartrate for essential tremor. N Engl J Med 1979;301:663.","journal-title":"N Engl J Med"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1001\/archneur.1980.00500580092022","article-title":"Metoprolol in essential tremor","volume":"37","author":"Newman, R.P.; Jacobs, L.","year":"1980","unstructured":"Newman RP, Jacobs L. Metoprolol in essential tremor. Arch Neutrol 1980;37:596-7.","journal-title":"Arch Neutrol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0140-6736(80)90519-X","article-title":"Metoprolol in essential tremor","volume":"1","author":"Turnbull, D.M.; Shaw, D.A.","year":"1980","unstructured":"Turnbull DM, Shaw DA. Metoprolol in essential tremor. Lancet 1980;1:95.","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1600-0773.1975.tb03323.x","article-title":"Influence of Metoprolol and Propranolol on hemodynamic effects induced by physical work and isoprenaline","volume":"36","author":"Johnsson, G.; Nyberg, G.; Solvell, L.","year":"1975","unstructured":"Johnsson G, Nyberg G, Solvell L. Influence of Metoprolol and Propranolol on hemodynamic effects induced by physical work and isoprenaline. Acta Pharmacol Toxicol (Kbh) 1975;36:69-75 (Supp. V). 19 Hewlett-Packard. Digital Signal Analyser: User's","journal-title":"Acta Pharmacol Toxicol (Kbh); Hewlett-Packard"},{"key":"ref_18","article-title":"HP 05420-900","author":"Guide","year":"1978","unstructured":"Guide. HP 05420-900, July 1978."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2125.1974.tb00201.x","article-title":"Observations on the effect of beta-adrenoceptor blocking drugs on glyceryltrinitrate tachycardia","volume":"1","author":"Kofi-Ekue, J.M.; Shanks, R.G.; Walsh, M.J.","year":"1974","unstructured":"Kofi-Ekue JM, Shanks RG, Walsh MJ. Observations on the effect of beta-adrenoceptor blocking drugs on glyceryltrinitrate tachycardia. Br J Clin Pharmacol 1974;1:19-26.","journal-title":"Br J Clin Pharmacol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2125.1974.tb00216.x","article-title":"The assessment of beta-adrenoceptor blocking drugs in hyperthyroidism","volume":"1","author":"Carruthers, S.G.; Ghosal, A.G.; McDevitt, D.G.; Nelson, J.K.; Shanks, R.G.","year":"1974","unstructured":"Carruthers SG, Ghosal AG, McDevitt DG, Nelson JK, Shanks RG. The assessment of beta-adrenoceptor blocking drugs in hyperthyroidism. Br J Clin Pharmacol 1974;1:93-8.","journal-title":"Br J Clin Pharmacol"},{"key":"ref_21","first-page":"53","article-title":"Peripheral beta-adrenergic receptors concerned with tremor","volume":"33","author":"Marsden, C.D.; Foley, T.H.; Owen, D.A.L.; McAllister, R.G.","year":"1967","unstructured":"Marsden CD, Foley TH, Owen DAL, McAllister RG. Peripheral beta-adrenergic receptors concerned with tremor. Clin Sci Mol Med 1967;33:53-65.","journal-title":"Clin Sci Mol Med"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF00558324","article-title":"Interaction or orally administered metoprolol, practolol and propranolol with isoprenaline","volume":"10","author":"Thiringer, G.; Svedmyr, N.","year":"1976","unstructured":"Thiringer G, Svedmyr N. Interaction or orally administered metoprolol, practolol and propranolol with isoprenaline. Eur J Clin Pharmacol 1976;10:163-70.","journal-title":"Eur J Clin Pharmacol"},{"key":"ref_23","article-title":"Effect of atenolol, metoprolol and propranolol on isoproterenolinduced tremor and tachycardia in normal subjects","author":"Perucca, E.; Pickles, H.; Richens, A.","year":"1981","unstructured":"Perucca E, Pickles H, Richens A. Effect of atenolol, metoprolol and propranolol on isoproterenolinduced tremor and tachycardia in normal subjects. Clin Pharniacol Ther 1981; (in press).","journal-title":"Clin Pharniacol Ther"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1056\/NEJM197909273011306","volume":"301","author":"Metoprolol, Koch-Weser J.","year":"1979","unstructured":"Koch-Weser J. Metoprolol. N Engl J Med 1979;301: 698-703.","journal-title":"N Engl J Med"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5694\/j.1326-5377.1975.tb95098.x","article-title":"Essential (hereditary or senile) tremor","volume":"2","author":"Sutherland, J.M.; Edwards, V.E.; Eadie, M.J.","year":"1975","unstructured":"Sutherland JM, Edwards VE, Eadie MJ. Essential (hereditary or senile) tremor. Med J Aust 1975;2: 44-7.","journal-title":"Med J Aust"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1212\/WNL.26.1.27","article-title":"Effect of propranolol on essential tremor","volume":"26","author":"Teravainen, H.; Fogelholm, R.; Larsen, A.","year":"1976","unstructured":"Teravainen H, Fogelholm R, Larsen A. Effect of propranolol on essential tremor. Neuirology (Minneap) 1976;26:27-30.","journal-title":"Neuirology (Minneap)"}],"container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp.44.9.814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T03:54:26Z","timestamp":1601092466000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp.44.9.814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9,1]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1981,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/jnnp.44.9.814","relation":{},"ISSN":["0022-3050"],"issn-type":[{"value":"0022-3050","type":"print"}],"subject":[],"published":{"date-parts":[[1981,9,1]]}}}