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Psychol Med 1981;11:39-48.","journal-title":"Psychol Med"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1136\/jnnp.47.3.250","article-title":"Deficient learning and memory in early and middle phases of multiple sclerosis","volume":"47","author":"Grant, I.; McDonald, W.I.; Trimble, M.R.; Smith, E.; Reed, R.","year":"1984","unstructured":"Grant I, McDonald WI, Trimble MR, Smith E, Reed R. Deficient learning and memory in early and middle phases of multiple sclerosis. J Neurol Neurosurg Psychiatry 1984;47:250-5.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/brain\/100.2.377","article-title":"Clinical testing of olfaction reassessed","volume":"100","author":"Pinching, A.","year":"1977","unstructured":"Pinching A. Clinical testing of olfaction reassessed. Brain 1977;100:377-88.","journal-title":"Brain"},{"key":"ref_67","first-page":"40","article-title":"Blood brain barrier damage in multiple sclerosis. Supravital test-observations","volume":"10","author":"Broman, T.","year":"1964","unstructured":"Broman T. Blood brain barrier damage in multiple sclerosis. Supravital test-observations. Acta Neurol Scand 1964; Supplement 10, 40:21-4.","journal-title":"Acta Neurol Scand"},{"key":"ref_68","first-page":"230","article-title":"Doyne Lecture. The significance of optic neuritis. Trans Ophthalmol Soc United Kingdom 1983; 103","author":"McDonald, W.I.","unstructured":"McDonald WI. Doyne Lecture. The significance of optic neuritis. Trans Ophthalmol Soc United Kingdom 1983;103:230-46."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0140-6736(84)92852-6","article-title":"Intravenous chelated gadolinium as a contrast agent in NMR imaging of cerebral tumours","volume":"i:","author":"Carr, D.H.; Brown, J.; Bydder, G.M.","year":"1984","unstructured":"Carr DH, Brown J, Bydder GM, et al. Intravenous chelated gadolinium as a contrast agent in NMR imaging of cerebral tumours. Lancet 1984;i:484-6.","journal-title":"Lancet"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0167-5699(81)90044-X","article-title":"The enigma of oligoclonal immunoglobulin G in the cerebrospinal fluid from multiple sclerosis patients","volume":"2","author":"Paterson, P.Y.; Whitacre, C.C.","year":"1981","unstructured":"Paterson PY, Whitacre CC. The enigma of oligoclonal immunoglobulin G in the cerebrospinal fluid from multiple sclerosis patients. Immunology Today 1981;2:111-7.","journal-title":"Immunology Today"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/305150a0","article-title":"Adoptive transfer of EAE-like lesions from rats with coronavius-induced demyelinating encephalomyelitis","volume":"305","author":"Watanabe, R.; Wege, H.; Ter Meulen, V.","year":"1983","unstructured":"Watanabe R, Wege H, Ter Meulen V. Adoptive transfer of EAE-like lesions from rats with coronavius-induced demyelinating encephalomyelitis. Nature 1983;305: 150-3.","journal-title":"Nature"},{"key":"ref_72","first-page":"\"474","article-title":"Histologisches Detail zu der grauen Degeneration vor Gehirn und Ruckenmartz (Zugleich ein Beitrag zu der Lehre vor der Ertstehung und Verwandlung der Zelle). Virchows Archivfur Pathologische Anatomie und Physiologie","volume-title":"93Charcot J-M. Histologie de la sclerose en plaques. Gazette H6pital, Paris 1868","volume":"26","author":"Rindfleisch, E.","unstructured":"Rindfleisch E. Histologisches Detail zu der grauen Degeneration vor Gehirn und Ruckenmartz (Zugleich ein Beitrag zu der Lehre vor der Ertstehung und Verwandlung der Zelle). Virchows Archivfur Pathologische Anatomie und Physiologie und fur Klinische Medizin 1863;26:474-83. 93Charcot J-M. Histologie de la sclerose en plaques. Gazette H6pital, Paris 1868;41:566."},{"key":"ref_73","first-page":"\"283","article-title":"Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture","volume":"174","author":"Raff, M.C.; Fields, K.L.; Hakomori, S.; Mirsky, R.; Pruss, R.M.; Winter, J.","year":"1979","unstructured":"Raff MC, Fields KL, Hakomori S, Mirsky R, Pruss RM, Winter J. Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture. Brain Res 1979;174:283-308. 9' Raff MC, Miller RH, Noble M. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium. Nature 1983;303:390-6.","journal-title":"Brain Res; 9' Raff MC, Miller RH, Noble M. A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/307273a0","article-title":"Astrocytes present myelin basic protein to encephalitogenic T-cell lines","volume":"307","author":"Fontana, A.; Wekerle, Fierz W.; H.","year":"1984","unstructured":"Fontana A, Fierz W. Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature 1984;307:273-6.","journal-title":"Nature"},{"key":"ref_75","first-page":"11","article-title":"Astrocyte-derived interleukin-l-like factors","volume":"3","author":"Fontana, A.; Grob, P.J.","year":"1984","unstructured":"Fontana A, Grob PJ. Astrocyte-derived interleukin-l-like factors. Lymphokine Research 1984;3: 11-6.","journal-title":"Lymphokine Research"},{"key":"ref_76","article-title":"Pathology of dementia. In: Recent Advances in Histopathology","author":"Janota, I.","year":"1981","unstructured":"Janota I. Pathology of dementia. In: Recent Advances in Histopathology. Anthony PP, Macsween RNM, eds. London: Churchill Livingstone, 1981."}],"container-title":["Journal of Neurology, Neurosurgery &amp; Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp.49.2.113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T11:09:28Z","timestamp":1709377768000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp.49.2.113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2,1]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/jnnp.49.2.113","relation":{},"ISSN":["0022-3050"],"issn-type":[{"value":"0022-3050","type":"print"}],"subject":[],"published":{"date-parts":[[1986,2,1]]}}}