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New York: Raven Press, 1984:261-73."},{"key":"ref_4","first-page":"821","article-title":"Immunocytochemical studies of human peripheral nerve with serum from patients with polyneuropathy and paraphenotypes seen in a normal population.24 It is still unknown how immunocompetent cells and antibodies can induce an antigen-antibody reaction against antigenic determinants on the other side of the proteinemia","volume":"32","author":"Abrams, G.M.; Latov, N.; Hays, A.P.; Sherman, W.; Zimmerman, E.A.","year":"1982","unstructured":"Abrams GM, Latov N, Hays AP, Sherman W, Zimmerman EA. Immunocytochemical studies of human peripheral nerve with serum from patients with polyneuropathy and paraphenotypes seen in a normal population.24 It is still unknown how immunocompetent cells and antibodies can induce an antigen-antibody reaction against antigenic determinants on the other side of the proteinemia. Neurology 1982;32:821-6.","journal-title":"Neurology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1212\/WNL.35.9.1321","article-title":"Axonal neuropathy in a patient with IgM M-protein reactive with nerve endoneurium","volume":"35","author":"Freddo, L.; Hays, A.P.; Sherman, W.H.; Latov, N.","year":"1985","unstructured":"Freddo L, Hays AP, Sherman WH, Latov N. Axonal neuropathy in a patient with IgM M-protein reactive with nerve endoneurium. Neurology 1985;35:1321-5.","journal-title":"Neurology"},{"key":"ref_6","first-page":"242","article-title":"Experimental blood-nerve-barrier. It has been observed that endothelial cells lining the vascular compartment may act as antigen-presenting cells2\" and thus represent the early stages for blood-nerve-barrier damage, which demyelination of nerve induced by serum of patients with neuropathy and an anti-MAG IgM M-protein","volume":"37","author":"Hays, A.P.; Latov, N.; Takatsu, M.; Sherman, W.H.","year":"1987","unstructured":"Hays AP, Latov N, Takatsu M, Sherman WH. Experimental blood-nerve-barrier. It has been observed that endothelial cells lining the vascular compartment may act as antigen-presenting cells2\" and thus represent the early stages for blood-nerve-barrier damage, which demyelination of nerve induced by serum of patients with neuropathy and an anti-MAG IgM M-protein. Neurology 1987;37:242-56.","journal-title":"Neurology"},{"key":"ref_7","first-page":"679","article-title":"Peripheral neuropathy, high serum IgM and paraproteinemia in a mother and ultimately may allow the passage of antibodies and\/or immunocompetent cells across the blood-nervebarrier. It is of interest to note that direct immunofluorescence study of brain specimens from son","volume":"35","author":"Busis, N.A.; Halperin, J.J.; Stefansson, K.","year":"1985","unstructured":"Busis NA, Halperin JJ, Stefansson K, et al. Peripheral neuropathy, high serum IgM and paraproteinemia in a mother and ultimately may allow the passage of antibodies and\/or immunocompetent cells across the blood-nervebarrier. It is of interest to note that direct immunofluorescence study of brain specimens from son. Neurology 1985;35:679-83.","journal-title":"Neurology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.0954-6820.1988.tb15795.x","article-title":"Autoimmunity related to IgM monoclonal gammopathy of undetermined significance","volume":"223","author":"Jonsson, V.; Schroder, H.D.; Jensen, T.S.","year":"1988","unstructured":"Jonsson V, Schroder HD, Jensen TS, et al. Autoimmunity related to IgM monoclonal gammopathy of undetermined significance. Acta Med Scand 1988;223:255-61.","journal-title":"Acta Med Scand"},{"key":"ref_9","article-title":"fluorescent Protein Tracing. Edinburgh: Churchill our case 2 showed binding of IgM to cerebral vascular tissue. This may represent a specific binding and thus support the view that endothelial cells occasionally may serve as antigen-presenting cells","author":"Nairn, R.G.","year":"1969","unstructured":"Nairn, RG. fluorescent Protein Tracing. Edinburgh: Churchill our case 2 showed binding of IgM to cerebral vascular tissue. This may represent a specific binding and thus support the view that endothelial cells occasionally may serve as antigen-presenting cells. Studies on Livingstone, 1969.","journal-title":"Studies on Livingstone"},{"key":"ref_10","article-title":"Immunocytochemistry","author":"Sternberger, L.A.","year":"1979","unstructured":"Sternberger LA. Immunocytochemistry. Englewood Cliffs NJ: Prentice Hall, 1979."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0165-5728(86)90001-9","article-title":"Peripheral neuropathy and monoclonal IgM with blood-nerve-barrier properties in patients with M proteins and neuropathy and in animals with experimental allergic neuritis may be rewarding in clarifying the pathogenesis of neuropathies in patients with antibody activity against peripheral nerve myelin; Effect of plasma exchange","volume":"11","author":"Ernerudh, J.; Brodtkorp, E.; Olsson, T.; Vedeler, C.A.; Nyland, H.; Berlin, G.","year":"1986","unstructured":"Ernerudh J, Brodtkorp E, Olsson T, Vedeler CA, Nyland H, Berlin G. Peripheral neuropathy and monoclonal IgM with blood-nerve-barrier properties in patients with M proteins and neuropathy and in animals with experimental allergic neuritis may be rewarding in clarifying the pathogenesis of neuropathies in patients with antibody activity against peripheral nerve myelin; Effect of plasma exchange. J Neuroimmunol 1986;11:171-8.","journal-title":"J Neuroimmunol"},{"key":"ref_12","first-page":"1225","article-title":"Igm in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a monoclonal gammopathies. It should be noted that while our studies are in agreement with previous reports showing binding of IgM proteins to myelinated tissue we do not know whether such binding is secondary to a preexisting blood-nervebarrier damage or is the result of a primary destruction of myelinated tissue followed by blood-nervebarrier damage and eventually antibody","volume-title":"access to ganglioside. Proc Natl Acad Sci","volume":"81","author":"Ilyas, A.A.; Quarles, R.H.; MacIntosh, T.D.","year":"1984","unstructured":"Ilyas AA, Quarles RH, MacIntosh TD, et al. Igm in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a monoclonal gammopathies. It should be noted that while our studies are in agreement with previous reports showing binding of IgM proteins to myelinated tissue we do not know whether such binding is secondary to a preexisting blood-nervebarrier damage or is the result of a primary destruction of myelinated tissue followed by blood-nervebarrier damage and eventually antibody access to ganglioside. Proc Natl Acad Sci USA 1984;81:1225-9."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/ana.410170305","article-title":"Polyneuropathy and IgM monoclonal gammopathy: studies on the pathogenetic role of antimyelin-associated glycoprotein antibody","volume":"17","author":"Mendell, JR, Sahenk; Z, Whitaker; J.N.","year":"1985","unstructured":"Mendell JR, Sahenk Z, Whitaker JN, et al. Polyneuropathy and IgM monoclonal gammopathy: studies on the pathogenetic role of antimyelin-associated glycoprotein antibody. Ann Neurol 1985;17:243-54.","journal-title":"Ann Neurol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(65)90344-2","article-title":"Familial occurrence of pathological serumproteins of different gammaglobulin groups","volume":"ii:","author":"Axelsson, U.; Hallen, J.","year":"1965","unstructured":"Axelsson U, Hallen J. Familial occurrence of pathological serumproteins of different gammaglobulin groups. Lancet 1965; ii:369-70.","journal-title":"Lancet"},{"key":"ref_15","first-page":"3883","article-title":"Peripheral neuropathy and plasma cell neoplasias: a report of 10 cases","volume":"48","author":"Delauche, M.C.; Clauvel, J.P.; Seligmann, M.","year":"1981","unstructured":"Delauche MC, Clauvel JP, Seligmann M. Peripheral neuropathy and plasma cell neoplasias: a report of 10 cases. Br J Haematol 1981;48:3883-92.","journal-title":"Br J Haematol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/blood.V62.2.280.280","article-title":"Waldenstr6m's macroglobulinemia and peripheral neuropathy: a clinical and immunologic study of 25 patients","volume":"62","author":"Dellagi, K.; Dupouey, P.; Brouet, J.C.","year":"1983","unstructured":"Dellagi K, Dupouey P, Brouet JC, et al. Waldenstr6m's macroglobulinemia and peripheral neuropathy: a clinical and immunologic study of 25 patients. Blood 1983;62:280-5.","journal-title":"Blood"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/ana.410210516","article-title":"IgG heavy chain (Gm) allotypes in demyelinating polyneuropathy associated with MAG-binding monoclonal IgM autoantibodies","volume":"21","author":"Kahn, S.H.; Pandey, J.P.","year":"1987","unstructured":"Kahn SH, Pandey JP. IgG heavy chain (Gm) allotypes in demyelinating polyneuropathy associated with MAG-binding monoclonal IgM autoantibodies. Ann Neurol 1987;21:507-9.","journal-title":"Ann Neurol"},{"key":"ref_18","first-page":"\"pp 90","article-title":"Biochemistry of the human blood-brain barrier","volume":"105","author":"Pardridge, W.M.","year":"1986","unstructured":"Pardridge WM. Biochemistry of the human blood-brain barrier, pp 90-94. In: Pardridge WM, moderator. Blood-brain Barrier: Interface Between Internal Medicine and the Brain. Ann Int Med 1986;105:88-95.","journal-title":"Ann Int Med; WM, moderator. 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