{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:11:55Z","timestamp":1780575115310,"version":"3.54.1"},"reference-count":48,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"published-print":{"date-parts":[[1991,8,1]]},"DOI":"10.1136\/jnnp.54.8.683","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T22:20:59Z","timestamp":1226355659000},"page":"683-688","source":"Crossref","is-referenced-by-count":278,"title":["Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines."],"prefix":"10.1136","volume":"54","author":[{"given":"D H","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Barkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Kappos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Scotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1212\/WNL.40.6.971","article-title":"Interrater variability with the expanded disability status scale (EDSS) and functional systems (FS) in a multiple sclerosis clinical trial","volume":"40","author":"Noseworthy, J.H.; Van der Voort, M.K.; Wong, C.J.; Ebers, G.C.","year":"1990","unstructured":"Noseworthy JH, Van der Voort MK, Wong CJ, Ebers GC. Interrater variability with the expanded disability status scale (EDSS) and functional systems (FS) in a multiple sclerosis clinical trial. Neurology 1990;40:971-5.","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0140-6736(81)91273-3","article-title":"Nuclear magnetic resonance imaging of the brain in multiple sclerosis","volume":"ii:","author":"Young, I.R.; Hall, A.S.; Pallis, C.A.","year":"1981","unstructured":"Young IR, Hall AS, Pallis CA, et al. Nuclear magnetic resonance imaging of the brain in multiple sclerosis. Lancet 1981;ii:1063-6.","journal-title":"Lancet"},{"key":"ref_3","first-page":"567","article-title":"Nuclear magnetic resonance imaging in multiple sclerosis","volume":"13","author":"Lukes, S.A.; Crooks, L.E.; AminoffMJ","year":"1983","unstructured":"Lukes SA, Crooks LE, AminoffMJ, et al. Nuclear magnetic resonance imaging in multiple sclerosis. Ann Neurol 1983;13:567-72.","journal-title":"Ann Neurol"},{"key":"ref_4","first-page":"1015","article-title":"Magnetic resonance imaging of multiple sclerosis: a study of pulsetechnique efficiency","volume":"143","author":"Runge, V.M.; Price, A.C.; Kirshner, H.S.","year":"1984","unstructured":"Runge VM, Price AC, Kirshner HS, et al. Magnetic resonance imaging of multiple sclerosis: a study of pulsetechnique efficiency. Am J Radiol 1984;143:1015-26.","journal-title":"Am J Radiol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF00333437","article-title":"Magnetic resonance in multiple sclerosis","volume":"28","author":"Scotti, G.; Scialfa, G.; Biondi, A.","year":"1986","unstructured":"Scotti G, Scialfa G, Biondi A, et al. Magnetic resonance in multiple sclerosis. Neuroradiol 1986;28:319-23.","journal-title":"Neuroradiol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/brain\/110.6.1579","article-title":"The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions: a quantitative study","volume":"110","author":"Ormerod, I.E.C.; Miller, D.H.; McDonald, W.I.","year":"1987","unstructured":"Ormerod IEC, Miller DH, McDonald WI, et al. The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions: a quantitative study. Brain 1987;110:1579-616.","journal-title":"Brain"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1212\/WNL.38.10.1511","article-title":"Multiple sclerosis: a serial study using MRI in relapsing patients","volume":"38","author":"Isaac, C.; Li, D.K.B.; Genton, M.","year":"1988","unstructured":"Isaac C, Li DKB, Genton M, et al. Multiple sclerosis: a serial study using MRI in relapsing patients. Neurology 1988; 38:1511-15.","journal-title":"Neurology"},{"issue":"1","key":"ref_8","first-page":"255","article-title":"GadoliniumDTPA-enhanced magnetic resonance imaging in the evaluation of different disease courses and disease activity in multiple sclerosis","volume":"38","author":"Kappos, L.; Staedt, D.; Rohrbach, E.; Keil, W.","year":"1988","unstructured":"Kappos L, Staedt D, Rohrbach E, Keil W. GadoliniumDTPA-enhanced magnetic resonance imaging in the evaluation of different disease courses and disease activity in multiple sclerosis. Neurology 1988;38(suppl 1):255.","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ana.410250107","article-title":"Serial magnetic resonance scanning in multiple sclerosis: a second prospective study in relapsing patients","volume":"25","author":"Willoughby, E.W.; Grochowski, E.; Li, D.K.B.","year":"1989","unstructured":"Willoughby EW, Grochowski E, Li DKB, et al. Serial magnetic resonance scanning in multiple sclerosis: a second prospective study in relapsing patients. Ann Neurol 1989;25:43-49.","journal-title":"Ann Neurol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ana.410290111","article-title":"Major differences in the dynamics of primary and secondary progressive multiple sclerosis","volume":"29","author":"Thompson, A.J.; Kermode, A.G.; Wicks, D.","year":"1991","unstructured":"Thompson AJ, Kermode AG, Wicks D, et al. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol 1991;29:53-62.","journal-title":"Ann Neurol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/ana.410260211","article-title":"Chronic progressive multiple sclerosis: serial magnetic resonance brain imaging over six months","volume":"26","author":"Koopmans, R.A.; Li, D.K.B.; Oger, J.J.F.","year":"1989","unstructured":"Koopmans RA, Li DKB, Oger JJF, et al. Chronic progressive multiple sclerosis: serial magnetic resonance brain imaging over six months. Ann Neurol 1989;26:248-56.","journal-title":"Ann Neurol"},{"key":"ref_12","article-title":"Co-planar stereotaxic atlas of the human brain","author":"Talairach, J.; Tournoux, P.","year":"1988","unstructured":"Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. Stuttgart: Thieme, 1988."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF00328179","article-title":"Magnetic resonance imaging in the evaluation of treatment in multiple sclerosis","volume":"30","author":"Kappos, L.; Staedt, D.; Ratzka, M.","year":"1988","unstructured":"Kappos L, Staedt D, Ratzka M, et al. Magnetic resonance imaging in the evaluation of treatment in multiple sclerosis. Neuroradiol 1988;30:299-302.","journal-title":"Neuroradiol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/brain\/111.4.927","article-title":"Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis","volume":"111","author":"Miller, D.H.; Rudge, P.; Johnson, G.","year":"1988","unstructured":"Miller DH, Rudge P, Johnson G, et al. Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis. Brain 1988;111:927-39.","journal-title":"Brain"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1148\/radiology.169.1.3420246","article-title":"Multiple sclerosis: serial study of gadolinium-enhanced MR imaging","volume":"169","author":"Grossman, R.I.; BrafEman, B.H.; Brorson, JR","year":"1988","unstructured":"Grossman RI, BrafEman BH, Brorson JR, et al. Multiple sclerosis: serial study of gadolinium-enhanced MR imaging. Radiology 1988;169:117-22.","journal-title":"Radiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1212\/WNL.40.4.591","article-title":"Serial study of gadolinium-DTPA MRI enhancement in multiple sclerosis","volume":"40","author":"Bastianello, S.; Pozzilli, C.; Bernadi, S.","year":"1990","unstructured":"Bastianello S, Pozzilli C, Bernadi S, et al. Serial study of gadolinium-DTPA MRI enhancement in multiple sclerosis. Neurology 1990;40:591-5.","journal-title":"Neurology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1212\/WNL.40.2.229","article-title":"Heterogeneity of blood-brain barrier changes in multiple sclerosis: an MRI study with gadolinium-DTPA enhancement","volume":"40","author":"Kermode, A.G.; Tofts, P.S.; Thompson, A.J.","year":"1990","unstructured":"Kermode AG, Tofts PS, Thompson AJ, et al. Heterogeneity of blood-brain barrier changes in multiple sclerosis: an MRI study with gadolinium-DTPA enhancement. Neurology 1990;40:229-35.","journal-title":"Neurology"},{"key":"ref_18","article-title":"Quantitative MR changes in gadolinium-DTPA enhancement after high dose intravenous methylprednisolone in multiple sclerosis","author":"Barkhof, F.; Hommes, O.R.; Ph, Scheltens; Valk, J.","unstructured":"Barkhof F, Hommes OR, Scheltens Ph, Valk J. Quantitative MR changes in gadolinium-DTPA enhancement after high dose intravenous methylprednisolone in multiple sclerosis. Neurology (in press)."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0730-725X(89)90547-X","article-title":"Improved sensitivity ofMRI in multiple sclerosis by use ofextensive standardised procedures","volume":"7","author":"de Vyver FL, Van; L, Truyen; J, Gheuens","year":"1989","unstructured":"Van de Vyver FL, Truyen L, Gheuens J, et al. Improved sensitivity ofMRI in multiple sclerosis by use ofextensive standardised procedures. MRI 1989;7:241-9.","journal-title":"MRI"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/brain\/113.2.365","article-title":"Duration and selectivity of blood-brain barrier breakdown in chronic relapsing experimental allergic encephalomyelitis studied using Gadolinium-DTPA and protein markers","volume":"113","author":"Hawkins, C.P.; Munro, P.M.G.; Mackenzie, F.","year":"1990","unstructured":"Hawkins CP, Munro PMG, Mackenzie F, et al. Duration and selectivity of blood-brain barrier breakdown in chronic relapsing experimental allergic encephalomyelitis studied using Gadolinium-DTPA and protein markers. Brain 1990;113:365-78.","journal-title":"Brain"},{"key":"ref_21","first-page":"643","article-title":"Gadoliniumenhanced MR imaging of acute and chronic experimental demyelinating lesions","volume":"9","author":"Kuharik, M.A.; Edwards, M.K.; Farlow, M.R.","year":"1988","unstructured":"Kuharik MA, Edwards MK, Farlow MR, et al. Gadoliniumenhanced MR imaging of acute and chronic experimental demyelinating lesions. Am J Neuroradiol 1988;9:643-8.","journal-title":"Am J Neuroradiol"},{"key":"ref_22","first-page":"243","article-title":"Gadoliniumenhancing lesion on magnetic resonance imaging: neuropathological findings","volume":"28","author":"Katz, J.; Taubenberger, J.; Raine, C.","year":"1990","unstructured":"Katz J, Taubenberger J, Raine C, et al. Gadoliniumenhancing lesion on magnetic resonance imaging: neuropathological findings. Ann Neurol 1990;28:243.","journal-title":"Ann Neurol"},{"key":"ref_23","first-page":"1058","article-title":"Serial gadolinium enhanced magnetic resonance imaging scans in patients with early relapsingremitting multiple sclerosis: implications for clinical trials and natural history","volume":"29","author":"Harris, J.O.; Frank, J.A.; Patronas, N.J.; McFarlin, D.E.; McFarland, H.F.","year":"1991","unstructured":"Harris JO, Frank JA, Patronas NJ, McFarlin DE, McFarland HF. Serial gadolinium enhanced magnetic resonance imaging scans in patients with early relapsingremitting multiple sclerosis: implications for clinical trials and natural history. Ann Neurol 1991;29:1058-65.","journal-title":"Ann Neurol"},{"key":"ref_24","first-page":"127","article-title":"Multiple sclerosis: diagnostic criteria and the role of contrast enhanced MRI","volume-title":"Contrast media in MRI","author":"Kappos, L.; Gold, R.; Hofmann, E.; Keil, W.; Clauss, W.","unstructured":"Kappos L, Gold R, Hofmann E, Keil W, Clauss W. Multiple sclerosis: diagnostic criteria and the role of contrast enhanced MRI. In: Bydder GM, Felix R, Bucheler E, et al, eds. Contrast media in MRI. Bussum: Medicom Europe 1990:127-35."},{"issue":"1","key":"ref_25","first-page":"17","article-title":"Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumours","volume":"16","year":"1990","unstructured":"Larsson HBW, Stubgaard M, Frederiksen JL, Jensen M, Hendriksen 0, Paulson OB. Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumours. Magnetic Resonance in Medicine 1990;16:1 17-131.","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref_26","first-page":"259","article-title":"Dosing of Gd-DTPA in MR imaging of intracranial tumours: a randomized, double-blind, multicentre study in 90 cases. Society of Magnetic Resonance in Medicine 9th annual meeting","volume":"1","author":"Haustein, J.; Bauer, W.; Hilbertz","year":"1990","unstructured":"Haustein J, Bauer W, Hilbertz, et al. Dosing of Gd-DTPA in MR imaging of intracranial tumours: a randomized, double-blind, multicentre study in 90 cases. Society of Magnetic Resonance in Medicine 9th annual meeting. (abstr). 1990;1:259."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0730-725X(90)90046-5","article-title":"The prospective evaluation of Gd-DTPA in 255 consecutive cranial cases: adverse reactions and diagnostic value","volume":"8","author":"Carrollo, B.R.; Runge, V.M.; Price, A.C.; Merlson, K.L.; Wolf, C.R.; Pacetti, M.I.","year":"1990","unstructured":"Carrollo BR, Runge VM, Price AC, Merlson KL, Wolf CR, Pacetti MI. The prospective evaluation of Gd-DTPA in 255 consecutive cranial cases: adverse reactions and diagnostic value. MRI 1990;8:381-93.","journal-title":"MRI"},{"issue":"1","key":"ref_28","first-page":"117","article-title":"TheeffectofGddimeglumine on subcutaneous tissues: a study with rats","volume":"1","author":"McAlisterWH, McAlister VI, KissaneJM","year":"1990","unstructured":"McAlisterWH, McAlister VI, KissaneJM. TheeffectofGddimeglumine on subcutaneous tissues: a study with rats. Am J Neuroradiol 1990;1 1:117-31.","journal-title":"Am J Neuroradiol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0730-725X(90)90019-X","article-title":"Severe anaphylactoid reaction after IV GdDTPA","volume":"8","author":"Weiss, K.L.","year":"1990","unstructured":"Weiss KL. Severe anaphylactoid reaction after IV GdDTPA. MRI 1990;8:817-18.","journal-title":"MRI"},{"key":"ref_30","first-page":"34","article-title":"Contrast media in MRI","volume":"1","author":"Carter, E.C.; Cornick, D.M.H.","year":"1991","unstructured":"Carter EC, Cornick DMH. Contrast media in MRI. Clinical MRI 1991;1:34-35.","journal-title":"Clinical MRI"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke, J.F.","year":"1983","unstructured":"Kurtzke JF, Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-53.","journal-title":"Neurology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/bmj.300.6725.631","article-title":"Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study","volume":"300","author":"Thompson, A.J.; Kermode, A.G.; MacManus, D.G.","year":"1990","unstructured":"Thompson AJ, Kermode AG, MacManus DG, et al. Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study. BMJ 1990;300:631-4.","journal-title":"BMJ"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/ana.410250112","article-title":"Benign versus chronic progressive multiple sclerosis: magnetic resonance imaging features","volume":"25","author":"Koopmans, R.A.; Li, D.K.B.; Grochowski, E.","year":"1989","unstructured":"Koopmans RA, Li DKB, Grochowski E, et al. Benign versus chronic progressive multiple sclerosis: magnetic resonance imaging features. Ann Neurol 1989;25:74-81.","journal-title":"Ann Neurol"},{"key":"ref_34","article-title":"McAlpine's multiple sclerosis","author":"Matthews, W.B.","year":"1991","unstructured":"Matthews WB, Matthews WB, eds. McAlpine's multiple sclerosis, 2nd ed. Edinburgh, Churchill Livingstone, 1991.","edition":"2nd ed"},{"key":"ref_35","first-page":"307","article-title":"MR imaging of experimental demyelination","volume":"10","author":"Teresi, L.M.; Hovda, D.; Seeley, A.B.; Nitta, K.; Lufkin, R.B.","year":"1989","unstructured":"Teresi LM, Hovda D, Seeley AB, Nitta K, Lufkin RB. MR imaging of experimental demyelination. Am JNeuroradiol 1989;10:307-14.","journal-title":"Am JNeuroradiol"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/ana.410220607","article-title":"Magnetic resonance imaging in isolated noncompressive spinal cord syndromes","volume":"22","author":"Miller, D.H.; McDonald, W.I.; Blumhardt, L.D.","year":"1987","unstructured":"Miller DH, McDonald WI, Blumhardt LD, et al. Magnetic resonance imaging in isolated noncompressive spinal cord syndromes. Ann Neurol 1987;22:714-23.","journal-title":"Ann Neurol"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1212\/WNL.38.2.175","article-title":"Magnetic resonance imaging of the optic nerve in optic neuritis","volume":"38","author":"Miller, D.H.; Newton, M.R.; van der Poel, J.C.","year":"1988","unstructured":"Miller DH, Newton MR, van der Poel JC, et al. Magnetic resonance imaging of the optic nerve in optic neuritis. Neurology 1988;38:175-9.","journal-title":"Neurology"},{"key":"ref_38","article-title":"Serial quantitative MR assessment of optic neuritis in a case of neuromyelitis optica, using gadolinium-\"enhanced\" STIR imaging","author":"Barkhof, F.; Ph, Scheltens; Valk, J.; Waalewijn, C.; Uitdehaag, B.M.J.; Polman, C.H.","unstructured":"Barkhof F, Scheltens Ph, Valk J, Waalewijn C, Uitdehaag BMJ, Polman CH. Serial quantitative MR assessment of optic neuritis in a case of neuromyelitis optica, using gadolinium-\"enhanced\" STIR imaging. Neuroradiology (in press)."},{"key":"ref_39","first-page":"161","article-title":"Temporary reduction of blood-brain barrier impairment in multiple sclerosis by high dose steroid therapy","volume":"1","author":"Miller, D.H.; Moseley, I.F.; Kendall, B.E.","year":"1991","unstructured":"Miller DH, Moseley IF, Kendall BE, et al. Temporary reduction of blood-brain barrier impairment in multiple sclerosis by high dose steroid therapy. JMRI 1991;1:161.","journal-title":"JMRI"},{"key":"ref_40","first-page":"1037","article-title":"Threedimensional segmentation ofMR images ofthe head using probability and connectivity","volume":"14","author":"Cline, H.E.; Lorensen, W.E.; Kikinis, R.; Jolesz, F.","year":"1990","unstructured":"Cline HE, Lorensen WE, Kikinis R, Jolesz F. Threedimensional segmentation ofMR images ofthe head using probability and connectivity. CAT 1990;14:1037-45.","journal-title":"CAT"},{"key":"ref_41","article-title":"The longstanding lesion: a quantitative MRI and electron microscopic study","author":"Barnes, D.; Munro, P.M.G.; Youl, B.D.; Prineas, J.W.; McDonald, W.I.","unstructured":"Barnes D, Munro PMG, Youl BD, Prineas JW, McDonald WI. The longstanding lesion: a quantitative MRI and electron microscopic study. Brain (in press)."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/mrm.1910030203","article-title":"Spin-lattice relaxation times (T1) of cerebral white matter in multiple sclerosis","volume":"3","author":"Lacomis, D.; Osbakken, M.; Gross, G.","year":"1986","unstructured":"Lacomis D, Osbakken M, Gross G. Spin-lattice relaxation times (T1) of cerebral white matter in multiple sclerosis. Magnetic Resonance in Medicine 1986;3:194-202.","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/mrm.1910070106","article-title":"vivo determination of Ti and T2 in the brain of patients with severe but stable multiple sclerosis","volume":"7","author":"Larsson, H.B.W.","year":"1988","unstructured":"Larsson HBW, Frederiksen J, Kjaer L, et al. In vivo determination of Ti and T2 in the brain of patients with severe but stable multiple sclerosis. Magnetic Resonance in Medicine 1988;7:43-55.","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/jnnp.52.12.1355","article-title":"Changes within the \"normal\" cerebral white matter of multiple sclerosis patients during acute attacks and during high-dose cortisone therapy assessed by means of quantitative MRI","volume":"52","author":"Brainin, M.; Neuhold, A.; Reisner, T.","year":"1989","unstructured":"Brainin M, Neuhold A, Reisner T, et al. Changes within the \"normal\" cerebral white matter of multiple sclerosis patients during acute attacks and during high-dose cortisone therapy assessed by means of quantitative MRI. J Neurol Neurosurg Psychiatry 1989;52:1355-9.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref_45","first-page":"1","article-title":"Precise relaxation time measurements of normal-appearing white matter in inflammatory central nervous system disease","volume":"1","author":"Miller, D.H.; Johnson, G.; Tofts, P.S.","year":"1989","unstructured":"Miller DH, Johnson G, Tofts PS, et al. Precise relaxation time measurements of normal-appearing white matter in inflammatory central nervous system disease. Magnetic Resonance in Medicine 1989;1 1:331-6.","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1212\/WNL.40.11.1764","article-title":"Proton magnetic resonance spectroscopy in multiple sclerosis","volume":"40","author":"Wolinsky, J.S.; Narayana, P.A.; Fenstermacher, M.J.","year":"1990","unstructured":"Wolinsky JS, Narayana PA, Fenstermacher MJ. Proton magnetic resonance spectroscopy in multiple sclerosis. Neurology 1990;40: 1764-9.","journal-title":"Neurology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/mrm.1910140115","article-title":"Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease","volume":"14","author":"Arnold, D.L.; Matthews, P.M.; Francis, G.; Antel","year":"1990","unstructured":"Arnold DL, Matthews PM, Francis G, Antel. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magnetic Resonance in Medicine 1990;14:154-9.","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/BF00588472","article-title":"Magnetic resonance: perfusion and diffusion imaging","volume":"32","author":"Doran, M.; Bydder, G.M.","year":"1990","unstructured":"Doran M, Bydder GM. Magnetic resonance: perfusion and diffusion imaging. Neuroradiology 1990;32:392-8.","journal-title":"Neuroradiology"}],"container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp.54.8.683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T02:37:48Z","timestamp":1601087868000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp.54.8.683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8,1]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1991,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/jnnp.54.8.683","relation":{},"ISSN":["0022-3050"],"issn-type":[{"value":"0022-3050","type":"print"}],"subject":[],"published":{"date-parts":[[1991,8,1]]}}}