{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:18:32Z","timestamp":1768882712690,"version":"3.49.0"},"reference-count":18,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"published-print":{"date-parts":[[1991,9,1]]},"DOI":"10.1136\/jnnp.54.9.768","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T22:20:59Z","timestamp":1226355659000},"page":"768-774","source":"Crossref","is-referenced-by-count":60,"title":["Patterns and severity of conduction abnormalities in Guillain-Barre syndrome."],"prefix":"10.1136","volume":"54","author":[{"given":"W F","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Snow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"405","article-title":"days apart. In case 4, however, despite the Patterns of conduction failure in the Guillain-Barre synsevere reductions in \"M\"A with wrist stimuladrome","volume":"111","author":"FGA, Van Der Meche; J, Meulstee; M, Vermeulen; A, Kievit","year":"1988","unstructured":"Van Der Meche FGA, Meulstee J, Vermeulen M, Kievit A. days apart. In case 4, however, despite the Patterns of conduction failure in the Guillain-Barre synsevere reductions in \"M\"A with wrist stimuladrome. Brain 1988;111:405-16.","journal-title":"Brain"},{"key":"ref_2","first-page":"344","article-title":"Proximal versus distal slowing of motor nerve tion at 5 (fig 2) and even 18 days, prompt recovery subsequently followed at 32 days strongly suggesting the previous terminal reduction in \"M\"A was largely explicable by conduction block in demyelinated nerve fibres rather than axonal degeneration. At the other extreme, inexcitable nerve carries the gloomy prospect of substantial axonal degeneration having taken place\"\"'5 and unfortunately was subsequently borne out by our case 14. How well did our studies correspond with the pathology of GBS? Haymaker and Kernohan2' examined 50 fatal cases. The interval conduction velocity in the Guillain-Barresyndrome","volume":"3","author":"Kimura, J.","year":"1978","unstructured":"Kimura J. Proximal versus distal slowing of motor nerve tion at 5 (fig 2) and even 18 days, prompt recovery subsequently followed at 32 days strongly suggesting the previous terminal reduction in \"M\"A was largely explicable by conduction block in demyelinated nerve fibres rather than axonal degeneration. At the other extreme, inexcitable nerve carries the gloomy prospect of substantial axonal degeneration having taken place\"\"'5 and unfortunately was subsequently borne out by our case 14. How well did our studies correspond with the pathology of GBS? Haymaker and Kernohan2' examined 50 fatal cases. The interval conduction velocity in the Guillain-Barresyndrome. Ann Neurol 1978;3:344-50.","journal-title":"Ann Neurol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/jnnp.47.3.288","article-title":"Sensory evoked potentials in Guillain-Barre polyneuropathy","volume":"47","author":"Brown, W.F.; Feasby, T.E.","year":"1984","unstructured":"Brown WF, Feasby TE. Sensory evoked potentials in Guillain-Barre polyneuropathy. J Neurol Neurosurg Psychiatry 1984;47:288-91.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/mus.880111005","article-title":"Reversible proximal conduction block underlies rapid recovery in GuillainBarre syndrome","volume":"11","author":"Berger, A.R.; Logigian, E.L.; Shahani, B.T.","year":"1988","unstructured":"Berger AR, Logigian EL, Shahani BT. Reversible proximal conduction block underlies rapid recovery in GuillainBarre syndrome. Muscle Nerve 1988;11: 1039-42.","journal-title":"Muscle Nerve"},{"key":"ref_5","first-page":"177","article-title":"The histological fine structure of perineurium","volume":"158","author":"Burkel, W.E.","year":"1967","unstructured":"Burkel WE. The histological fine structure of perineurium. AnatRec 1967;158:177-90.","journal-title":"AnatRec"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/BF00690507","article-title":"Topographical differences in the vascular permeability of the peripheral nervous system","volume":"10","author":"Olsson, Y.","year":"1968","unstructured":"Olsson Y. Topographical differences in the vascular permeability of the peripheral nervous system. 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Pathological changes were most evident biotin system","volume":"68","author":"Seitz, R.J.; Heininger, K.; Schwendemann, G.; Toyka, K.V.; Wechsler, W.","year":"1985","unstructured":"Seitz RJ, Heininger K, Schwendemann G, Toyka KV, Wechsler W. The mouse blood-brain barrier and bloodological studies varied between two and 46 nerve barrier for IgG: A tracer study by use of the avidindays. Pathological changes were most evident biotin system. Acta Neuropathol (Berl) 1985;68:15-21.","journal-title":"Acta Neuropathol (Berl)"},{"key":"ref_9","first-page":"1","article-title":"Diagnostic considerations in Guillain-Barre spinal at the junction between motor and sensory roots and the mixed nerve roots. Lesions syndrome","volume":"9","author":"Asbury, A.K.","year":"1981","unstructured":"Asbury AK. Diagnostic considerations in Guillain-Barre spinal at the junction between motor and sensory roots and the mixed nerve roots. Lesions syndrome. Ann Neurol 1981;9(suppl): 1-5.","journal-title":"Ann Neurol"},{"key":"ref_10","first-page":"125","article-title":"Treatment of acute inflammatory polyneuropathy. Ann Neurol tended to be multifocal in distribution, often varying widely in intensity from fascicle to fascicle. However, the PNS distal to the roots was not assessed and intramuscular branches","volume":"9","author":"Hughes, R.A.C.; Kadlubowski, M.; Hufschmidt, A.","year":"1981","unstructured":"Hughes RAC, Kadlubowski M, Hufschmidt A. Treatment of acute inflammatory polyneuropathy. Ann Neurol tended to be multifocal in distribution, often varying widely in intensity from fascicle to fascicle. However, the PNS distal to the roots was not assessed and intramuscular branches 1981;9(suppl): 125-33."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/brain\/109.6.1115","article-title":"Acute axonal form of Guillain-Barre polyneuropathy","volume":"109","author":"Feasby, T.E.; Gilbert, J.J.; Brown, W.F.","year":"1986","unstructured":"Feasby TE, Gilbert JJ, Brown WF, et al. Acute axonal form of Guillain-Barre polyneuropathy. Brain 1986;109: 1115-26.","journal-title":"Brain"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/ana.410230407","article-title":"et aland the Guillain-Barre Study Group. Motor conduction studies in were not studied. Guillain-Barre syndrome: description and prognostic In the study by Asbury et al,22 19 fatal cases value","volume":"23","author":"Cornblath, D.R.; Mellts, E.D.; Griffin, J.W.","year":"1988","unstructured":"Cornblath DR, Mellts ED, Griffin JW, et aland the Guillain-Barre Study Group. Motor conduction studies in were not studied. Guillain-Barre syndrome: description and prognostic In the study by Asbury et al,22 19 fatal cases value. Ann Neurol 1988;23:354-9.","journal-title":"Ann Neurol"},{"key":"ref_13","first-page":"759","article-title":"The pathogenesis of day and six years. Nine cases were studied within the first four weeks. Patterns varied from predominant involvement of the roots, with the ventral roots being the more affected, to widespread involvement of roots and peripheral nerve trunks, and still other cases where peripheral nerve trunks themselves were affected with little or no involvement ofthe roots. In the few cases where intramuscular nerve twigs were examined, striking pathological changes pneumatic tourniquet paralysis in man","volume":"44","author":"Yates, S.K.; Hurst, L.N.; Brown, W.F.","year":"1981","unstructured":"Yates SK, Hurst LN, Brown WF. The pathogenesis of day and six years. Nine cases were studied within the first four weeks. Patterns varied from predominant involvement of the roots, with the ventral roots being the more affected, to widespread involvement of roots and peripheral nerve trunks, and still other cases where peripheral nerve trunks themselves were affected with little or no involvement ofthe roots. In the few cases where intramuscular nerve twigs were examined, striking pathological changes pneumatic tourniquet paralysis in man. J Neurol Neurosurg Psychiatry 1981;44:759-67.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mus.880110209","article-title":"Axonal conduction velocity and force of single human motor units","volume":"11","author":"Dengler, R.; Stein, R.B.; Thomas, C.K.","year":"1988","unstructured":"Dengler R, Stein RB, Thomas CK. Axonal conduction velocity and force of single human motor units. 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