{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:13:27Z","timestamp":1781774007657,"version":"3.54.5"},"reference-count":19,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"published-print":{"date-parts":[[1992,2,1]]},"DOI":"10.1136\/jnnp.55.2.136","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T22:20:59Z","timestamp":1226355659000},"page":"136-137","source":"Crossref","is-referenced-by-count":18,"title":["Thiamine status in inherited degenerative ataxias."],"prefix":"10.1136","volume":"55","author":[{"given":"O L","family":"Pedraza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M I","family":"Botez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","article-title":"Canada H2W 1T8 0 L Pedraza","volume-title":"and in revised form","year":"1991","unstructured":"L Pedraza, M I Botez Neurology Service, Hotel-Dieu de Montreal, 3840 StUrbain Street, Montreal, Quebec, Canada H2W 1T8 0 L Pedraza M I Botez Correspondence to: Dr Botez Received 30 January 1991 and in revised form 20 May 1991. Accepted 13 June 1991"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.nu.08.070188.002411","article-title":"Thiamine and the brain. A review","volume":"8","author":"Haas, R.H.","year":"1988","unstructured":"Haas RH. Thiamine and the brain. A review. Ann Rev Nutr 1988;8:483-515.","journal-title":"Ann Rev Nutr"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/jnnp.45.8.731","article-title":"Thiamine deficiency and cerebrospinal fluid 5-hydroxyindoleacetic acid: a preliminary study","volume":"45","author":"Botez, M.I.; Young, S.N.; Bachevalier, J.; Gauthier, S.","year":"1982","unstructured":"Botez MI, Young SN, Bachevalier J, Gauthier S. Thiamine deficiency and cerebrospinal fluid 5-hydroxyindoleacetic acid: a preliminary study. J Neurol Neurosurg Psychiatry 1982;45:731-3.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1136\/jnnp.44.7.574","article-title":"Biochemical and clinical studies of Friedreich's ataxia","volume":"44","year":"1981","unstructured":"Purkiss P, Baraitser M, Borud 0, Chalmers RA. Biochemical and clinical studies of Friedreich's ataxia. J Neurol Neurosurg Psychiatry 1981;44:574-82.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref_5","first-page":"141","article-title":"Cerebrospinal fluid, plasma and erythrocyte thiamine levels in ataxias of degenerative origin","volume":"4","author":"Poloni, M.; Patrini, C.","year":"1984","unstructured":"Poloni M, Patrini C. Cerebrospinal fluid, plasma and erythrocyte thiamine levels in ataxias of degenerative origin. Ital J Neurol Sci 1984;suppl 4:141-3.","journal-title":"Ital J Neurol Sci"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/brain\/104.3.589","article-title":"Friedreich's ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features","volume":"104","author":"Harding, A.E.","year":"1981","unstructured":"Harding AE. Friedreich's ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features. Brain 1981;104:589-620.","journal-title":"Brain"},{"key":"ref_7","first-page":"39","article-title":"Morphological changes of olivopontocerebellar atrophy in computed tomography and comments on its pathogenesis","volume-title":"The olivopontocerebellar atrophies","volume":"41","author":"Huang, Y.P.; Plaitakis, A.","year":"1984","unstructured":"Huang YP, Plaitakis A. Morphological changes of olivopontocerebellar atrophy in computed tomography and comments on its pathogenesis. In: Duvoisin RC, Plaitakis A, eds. The olivopontocerebellar atrophies. New York: Raven Press 1984;41:39-85."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1212\/WNL.31.4_Part_2.405","article-title":"Cerebellar atrophy demonstrated by computed tomography","volume":"31","author":"Koller, W.C.; Glatt, S.L.; Perlik, S.; Huckman, M.S.; Fox, J.H.","year":"1981","unstructured":"Koller WC, Glatt SL, Perlik S, Huckman MS, Fox JH. Cerebellar atrophy demonstrated by computed tomography. Neurology 1981;31:405-12.","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1017\/S0317167100027785","article-title":"Cerebellar atrophy in epileptic patients","volume":"15","author":"Botez, M.I.; Attig, E.; Vezina, J.L.","year":"1988","unstructured":"Botez MI, Attig E, Vezina JL. Cerebellar atrophy in epileptic patients. Can J Neurol Sci 1988;15:299-303.","journal-title":"Can J Neurol Sci"},{"key":"ref_10","first-page":"333","article-title":"Effects of anticonvulsivant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid","volume":"114","author":"Botez, M.I.; Young, S.N.","year":"1991","unstructured":"Botez MI, Young SN. Effects of anticonvulsivant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid. Brain 1991;114:333-48.","journal-title":"Brain"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1017\/S0317167100024793","article-title":"Autosomal recessive spastic ataxia of CharlevoixSaguenay","volume":"5","author":"Bouchard, J.P.; Barbeau, A.; Bouchard, R.; Bouchard, R.W.","year":"1978","unstructured":"Bouchard JP, Barbeau A, Bouchard R, Bouchard RW. Autosomal recessive spastic ataxia of CharlevoixSaguenay. Can JNeurol Sci 1978;5:61-9.","journal-title":"Can JNeurol Sci"},{"key":"ref_12","first-page":"223","article-title":"Chronic toxicity of antiepileptic drugs with respect to cerebellar and motor function","volume-title":"Chronic toxicity of antiepileptic drugs","author":"Dam, M.","year":"1983","unstructured":"Dam M. Chronic toxicity of antiepileptic drugs with respect to cerebellar and motor function. In: Oxley J, Janz D, Meinhardi H, eds. Chronic toxicity of antiepileptic drugs, New York: Raven Press 1983:223-8."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0006-8993(80)90619-8","article-title":"Thiamine content and turnover rates of some rat nervous regions, using labeled thiamine as a tracer","volume":"181","author":"Rindi, G.; Patrini, C.; Comincioli, V.; Reggiani, C.","year":"1980","unstructured":"Rindi G, Patrini C, Comincioli V, Reggiani C. Thiamine content and turnover rates of some rat nervous regions, using labeled thiamine as a tracer. Brain Res 1980; 181:369-80.","journal-title":"Brain Res"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0014-4886(70)90184-6","article-title":"Distribution of thiamine phosphate esters in normal and thiamine deficient brain","volume":"28","author":"Pincus, J.M.; Grove, Y.","year":"1970","unstructured":"Pincus JM, Grove Y. Distribution of thiamine phosphate esters in normal and thiamine deficient brain. Exp Neurol 1970;28:477-83.","journal-title":"Exp Neurol"},{"key":"ref_15","first-page":"219","article-title":"Cerebellar degeneration in thiamine deficient rats","volume":"58","author":"Collins, G.H.; Converse, W.K.","year":"1967","unstructured":"Collins GH, Converse WK. Cerebellar degeneration in thiamine deficient rats. Am J Pathol 1967;58:219-33.","journal-title":"Am J Pathol"},{"key":"ref_16","first-page":"1081","article-title":"Ultrastructural changes of features of early brainstem lesions in thiamine deficient rats","volume":"52","author":"Robertson, D.M.; Wasan, S.M.; Skinner, D.B.","year":"1968","unstructured":"Robertson DM, Wasan SM, Skinner DB. Ultrastructural changes of features of early brainstem lesions in thiamine deficient rats. Am J Pathol 1968;52:1081-7.","journal-title":"Am J Pathol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/ana.410130404","article-title":"Intermittent thiamine deficiency in the rhesus monkey. I. Progression of neurological signs and neuroanatomical lesions","volume":"13","author":"Witt, E.D.; Goldman-Rakic, P.","year":"1983","unstructured":"Witt ED, Goldman-Rakic P. Intermittent thiamine deficiency in the rhesus monkey. I. Progression of neurological signs and neuroanatomical lesions. Ann Neurol 1983;13:376-95.","journal-title":"Ann Neurol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1113\/jphysiol.1982.sp014222","article-title":"Kinetics of thiamine transport across the blood-brain barrier in the rat","volume":"327","author":"Greenwood, J.; Love, E.R.; Pratt, O.E.","year":"1982","unstructured":"Greenwood J, Love ER, Pratt OE. Kinetics of thiamine transport across the blood-brain barrier in the rat. J Physiol 1982;327:95-103.","journal-title":"J Physiol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0006-8993(84)91239-3","article-title":"Nervous tissue thiamine metabolism in vivo. I. Transport of thiamine and thiamine monophosphate from plasma to different brain regions of the rat","volume":"293","author":"Reggiani, C.; Patrini, C.; Rindi, G.","year":"1984","unstructured":"Reggiani C, Patrini C, Rindi G. Nervous tissue thiamine metabolism in vivo. I. Transport of thiamine and thiamine monophosphate from plasma to different brain regions of the rat. Brain Res 1984;293:319-27.","journal-title":"Brain Res"}],"container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp.55.2.136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T02:39:26Z","timestamp":1601087966000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp.55.2.136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2,1]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/jnnp.55.2.136","relation":{},"ISSN":["0022-3050"],"issn-type":[{"value":"0022-3050","type":"print"}],"subject":[],"published":{"date-parts":[[1992,2,1]]}}}