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Neurology 1984;34:939-44.","journal-title":"Neurology"},{"key":"ref_29","first-page":"189","article-title":"\"Mini-mental state\": a practical method for grading the cognitive state of patients for the clinician..7 Psychiatry","volume":"12","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR. \"Mini-mental state\": a practical method for grading the cognitive state of patients for the clinician..7 Psychiatry Res 1975;12: 189-98.","journal-title":"Res"},{"key":"ref_30","first-page":"734","article-title":"The brief cognitive rating scale (BCRS): findings in primary degenerative dementia (PDD)","volume":"19","author":"Reisberg, B.; Schneck, M.K.; Ferris, S.H.","year":"1983","unstructured":"Reisberg B, Schneck MK, Ferris SH. The brief cognitive rating scale (BCRS): findings in primary degenerative dementia (PDD). Psychopharmacol Bull 1983;19:734-9.","journal-title":"Psychopharmacol Bull"},{"key":"ref_31","first-page":"257","article-title":"Clinical analysis of the disability on Parkinson's disease. Mod Treat 1968; 5","author":"Webster, D.D.","unstructured":"Webster DD. Clinical analysis of the disability on Parkinson's disease. Mod Treat 1968;5:257-62."},{"issue":"23","key":"ref_32","first-page":"56","article-title":"A rating scale for depresssion. _7 Neurol","volume":"1960","author":"Hamilton, M.","unstructured":"Hamilton M. A rating scale for depresssion. _7 Neurol Neurosurg Psychiatry 1960;23:56-62.","journal-title":"Neurosurg Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/ana.410070516","article-title":"Pathological verification of ischemic score in differentiation of dementias","volume":"7","author":"Rosen, W.G.; Terry, R.D.; Fuld, P.A.","year":"1980","unstructured":"Rosen WG, Terry RD, Fuld PA, et al. Pathological verification of ischemic score in differentiation of dementias. Ann Neurol 1980;7:486-8.","journal-title":"Ann Neurol"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1212\/WNL.44.9.1660","article-title":"Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: correlation to visual and verbal memory","volume":"44","author":"Soininen, H.; Partanen, K.; Pitkanen, A.","year":"1994","unstructured":"Soininen H, Partanen K, Pitkanen A, et al. Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: correlation to visual and verbal memory. Neurology 1994; 44:1660-8.","journal-title":"Neurology"},{"key":"ref_35","article-title":"Structure of the human brain. A photographic atlas","author":"DeArmond, S.J.; Fusco, M.M.; Dewey, M.M.","year":"1989","unstructured":"DeArmond SJ, Fusco MM, Dewey MM. Structure of the human brain. 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A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease Jf Neurol Neurosurg Psychiatry 1992;55:1182-7.","journal-title":"Jf Neurol Neurosurg Psychiatry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0168-0102(92)90071-J","article-title":"Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain","volume":"14","author":"Sato, A.; Sato, Y.","year":"1992","unstructured":"Sato A, Sato Y. Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain. Neurosci Res 1992;14:242-74.","journal-title":"Neurosci Res"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/oso\/9780198542667.003.0008","article-title":"Cellular mechanisms of cholinergic control of neocortical and thalamic neuronal excitability","volume-title":"cholinergic systems","author":"McCormick, D.A.","year":"1990","unstructured":"McCormick DA. Cellular mechanisms of cholinergic control of neocortical and thalamic neuronal excitability. In: Steriade M, Biesold D, eds. Brain cholinergic systems. New York: University Press, 1990:236-64."}],"container-title":["Journal of Neurology, Neurosurgery & Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jnnp.60.6.644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T16:48:42Z","timestamp":1738514922000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnnp.bmj.com\/lookup\/doi\/10.1136\/jnnp.60.6.644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6,1]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/jnnp.60.6.644","relation":{},"ISSN":["0022-3050"],"issn-type":[{"value":"0022-3050","type":"print"}],"subject":[],"published":{"date-parts":[[1996,6,1]]}}}