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Trends Neurosci 1982;5386-90.","journal-title":"Trends Neurosci"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1212\/WNL.36.7.879","article-title":"Positron emission tomography in Alzheimer's disease","volume":"36","author":"Duara, R.; Grady, C.L.; Haxby, J.V.","year":"1986","unstructured":"Duara R, Grady CL, Haxby JV, et al. Positron emission tomography in Alzheimer's disease. Neurology 1986;36: 879-87.","journal-title":"Neurology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/archneur.1986.00520090022010","article-title":"Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer'stype dementia","volume":"43","author":"Haxby, J.V.; Grady, C.L.; Duara, R.; Schlageter, N.; Berg, G.; Rapoport, S.I.","year":"1986","unstructured":"Haxby JV, Grady CL, Duara R, Schlageter N, Berg G, Rapoport SI. 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