{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:39:41Z","timestamp":1755225581409,"version":"3.43.0"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Army Med Corps"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Common Variable Immunodeficiency (CVID) is the commonest form of severe antibody deficiency. It is characterized by reduced levels of IgG (&lt;400mg\/dL) and low IgA and\/or IgMlevels, recurrent bacterial infections, impaired antibody responses despite the presence of B Cells and normal or near normal T immunity in 60% of patients. There is a high mortality from infections without treatment. The main stay treatment is to replace the immunoglobulins.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case Presentation<\/jats:title>\n                  <jats:p>We describe a British soldier with a 10 year history of recurrent chest infections, sinusitis and otitis media. He repeatedly presented 2 to 3 times a year complaining of either a green nasal discharge or a cough productive of yellow\/green sputum. He presented three years ago with severe sinusitis which resulted in investigations highlighting hypogammaglobulinaemia. Subsequently he was started on immunoglobulin therapy with Flebogamma 40g three weekly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Recommendations<\/jats:title>\n                  <jats:p>Despite being a relatively rare condition, CVID when diagnosed, can be easily treated and improve patients' prognosis. Medical Officers should be aware of the condition as a differential diagnosis for individuals presenting with recurrent infections.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jramc-154-01-15","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T19:43:32Z","timestamp":1363722212000},"page":"54-56","source":"Crossref","is-referenced-by-count":1,"title":["An Unusual Case of Sinusitis"],"prefix":"10.1136","volume":"154","author":[{"given":"LEM","family":"Lamb","sequence":"first","affiliation":[{"name":"Chelsea and Westminister Hospital, 369 Fulham Road, London, SW10 9NH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Richards","sequence":"additional","affiliation":[{"name":"Army Primary Health Service, North-East, Permanent Standing Medical Board, Duchess of Kent Barracks, Catterick Garrison, North Yorkshire, DL9 4DF"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JDM","family":"Edgar","sequence":"additional","affiliation":[{"name":"Regional Immunology Service, Immunology Day Centre, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BN."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"issue":"1","key":"ref_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"CVID; clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles, C.; Bodian, C.","year":"1999","unstructured":"Cunningham-Rundles C, Bodian C. CVID; clinical and immunological features of 248 patients. Clin Immunol 1999; 92(1): 34-48.","journal-title":"Clin Immunol"},{"issue":"4","key":"ref_2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0002-9343(86)90812-0","article-title":"Increase susceptibility to mycoplasma in patients with hypogammoglobulinaemia","volume":"80","author":"Roifman, C.M.; Rao, C.P.; Lederman, H.M.; Lavi, S.; Quinn, P.; Gelfand, E.W.","year":"1986","unstructured":"Roifman CM, Rao CP, Lederman HM, Lavi S, Quinn P, Gelfand EW. Increase susceptibility to mycoplasma in patients with hypogammoglobulinaemia. Am J Med 1986; 80(4); 590-4.","journal-title":"Am J Med"},{"issue":"6","key":"ref_3","first-page":"1001","article-title":"Efficacy of ivig in presentation of pneumonia in patients with CVID","volume":"109","author":"Busse, P.J.; Razvi, S.; Cunningham-Rundles, C.","year":"2002","unstructured":"Busse PJ, Razvi S, Cunningham-Rundles C. Efficacy of ivig in presentation of pneumonia in patients with CVID. J Allergy Clin Immunol 2002; 109(6): 1001-4.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"ref_4","first-page":"22","article-title":"GI manifestations of Primary Immunodeficiency Disorders","volume":"8","author":"LaiPing, S.O.A.; Mayer, L.","year":"1997","unstructured":"LaiPing SOA, Mayer L. GI manifestations of Primary Immunodeficiency Disorders. Semin Gastrointest Dis 1997; 8(1): 22-32.","journal-title":"Semin Gastrointest Dis"},{"issue":"5","key":"ref_5","first-page":"251","volume":"75","author":"Fasano, M.B.; Sullivan, K.E.; Sarpong, S.B.","year":"1996","unstructured":"Fasano MB, Sullivan KE, Sarpong SB et al. Sarcoidosis and CVID. Report of 8 cases and review of the literature. Medicine (Baltimore) 1996; 75(5): 251-61.","journal-title":"Report of 8 cases and review of the literature. Medicine (Baltimore)"},{"issue":"4","key":"ref_6","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/BF00915550","article-title":"Incidence of cancer in 98 patients with CVID","volume":"7","author":"Cunningham-Rundles, C.; Siegel, F.P.; Cunningham-Rundles, S.","year":"1987","unstructured":"Cunningham-Rundles C, Siegel FP, Cunningham-Rundles S et al. Incidence of cancer in 98 patients with CVID. J Clin Immunol 1987; 7(4): 294-9.","journal-title":"J Clin Immunol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic Criteria for Common Variable Immunodeficiency","volume":"93","author":"Conley, M.E.; Notarangelo, L.D.; Etzioni, A.","year":"1999","unstructured":"Conley ME, Notarangelo LD, Etzioni A. Diagnostic Criteria for Common Variable Immunodeficiency. Clin Immunol 1999; 93:190","journal-title":"Clin Immunol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1542\/peds.9.6.722","volume":"9","author":"Bruton, O.C.Agammaglobulinaemia","year":"1952","unstructured":"Bruton, OC. Agammaglobulinaemia. Pediatrics 1952; 9: 722.","journal-title":"Pediatrics"},{"issue":"6","key":"ref_9","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1067\/mai.2002.124999","article-title":"Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency","volume":"109","author":"Busse, P.J.; Razvi, S.; Cunningham-Rundles, C.","year":"2002","unstructured":"Busse PJ, Razvi S, Cunningham-Rundles C. Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency. J Allergy Clin Immunol 2002; 109(6): 1001-4.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"ref_10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jaut.2005.04.006","article-title":"Treatment and outcome of autoimmune hematological disease in common variable immunodeficiency","volume":"25","author":"Wang, J.; Cunningham-Rundles, C.","year":"2005","unstructured":"Wang J, Cunningham-Rundles C. Treatment and outcome of autoimmune hematological disease in common variable immunodeficiency. J Autoimmun 2005; 25(1): 57-62.","journal-title":"J Autoimmun"},{"key":"ref_11","unstructured":"AC13371 PULHHEEMS Administrative Pamphlet 2000 Ministry of Defence D\/DM(A)82\/32\/D\/STOS. 12. Joint Services Publication 346 PULHHEEMS \u2013 A Joint Services System of Medical Classification.","article-title":"AC13371 PULHHEEMS Administrative Pamphlet 2000 Ministry of Defence D\/DM(A)82\/32\/D\/STOS. 12. 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AC71642 Crown Copyright February 2000."}],"container-title":["Journal of the Royal Army Medical Corps"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jramc-154-01-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T14:58:31Z","timestamp":1755097111000},"score":1,"resource":{"primary":{"URL":"https:\/\/militaryhealth.bmj.com\/lookup\/doi\/10.1136\/jramc-154-01-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,3,1]]},"published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1136\/jramc-154-01-15"],"URL":"https:\/\/doi.org\/10.1136\/jramc-154-01-15","relation":{},"ISSN":["0035-8665","2052-0468"],"issn-type":[{"type":"print","value":"0035-8665"},{"type":"electronic","value":"2052-0468"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}