{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:18:50Z","timestamp":1756462730524},"reference-count":6,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J R Army Med Corps"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>Musculoskeletal infections caused by Panton-Valentine Leukocidin (PVL) secreting Stapylocccus aureus in children and adolescents have previously been reported. We report the first adult case in a 26 year-old British Army soldier who presented with a S. aureus septic arthritis. He was treated by surgical washout and antibiotics and discharged but was readmitted five months later with an ipsilateral femoral osteomyelitis requiring debridement. The causative S. aureus grown from tissue biopsy taken at time of surgery was found to encode the PVL gene. Whilst there is evidence that soldiers in Iraq have a greater rate of S. aureus colonisation on their skin, the proportion that encode the PVL gene is similar to that observed in the UK. Soldiers are however, subject to the known risk factors that increase vulnerability to PVL secreting S. aureus infection. Military clinicians need to be aware of PVL secreting S. aureus and have a low threshold for requesting specific testing in aggressive musculoskeletal S. aureus infections.<\/jats:p>","DOI":"10.1136\/jramc-155-03-08","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T23:43:32Z","timestamp":1363736612000},"page":"208-209","source":"Crossref","is-referenced-by-count":2,"title":["PVL Staphylococcus Aureus Osteomyelitis Complicating Septic Arthritis in a Uk Soldier Serving in Iraq"],"prefix":"10.1136","volume":"155","author":[{"given":"Jowan G","family":"Penn-Barwell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Finnikin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Sargeant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"ref_1","first-page":"43","article-title":"Panton-Valentine Leukocidin Genes are associated with Enhanced inflammatory Response and Local Disease in Acute Hematogenous Staphylococcus aureus Osteomyelitis in Children","volume":"117","author":"Bocchini, C.E.; Hulten, K.G.; Mason, E.O.; Gonzalez, B.E.; Hammerman, W.A.; Kaplan, S.L.","year":"2006","unstructured":"Bocchini CE, Hulten KG, Mason EO, Gonzalez BE, Hammerman WA, Kaplan SL. Panton-Valentine Leukocidin Genes are associated with Enhanced inflammatory Response and Local Disease in Acute Hematogenous Staphylococcus aureus Osteomyelitis in Children. Pediatrics. 2006; 117: 43-440","journal-title":"Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.diagmicrobio.2006.03.007","article-title":"Severe Osteoarticular infection associated with Panton-Valentine leucocidin producing Staphylococcus aureus","volume":"56","author":"Moumile, K.; Cadilhac, C.; Lina, G.; Berche, P.; Glorion, C.; Ferroni, A.","year":"2006","unstructured":"Moumile K, Cadilhac C, Lina G, Berche P, Glorion C, Ferroni A. Severe Osteoarticular infection associated with Panton-Valentine leucocidin producing Staphylococcus aureus. Diagn Microbiol Infect Dis. 2006; 56: 95-7","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"508","key":"ref_3","first-page":"4","article-title":"Staphylococcal poreforming toxins","volume":"506","author":"Panton, P.N.; Lancet, Valentine F.C.O.Staphyococcal Toxin","year":"1932","unstructured":"Panton PN, Valentine FCO. Staphyococcal Toxin. Lancet. 1932; i: 506-508 4. Prevost G, Mourey D, Colin A, Menestrina G. Staphylococcal poreforming toxins. Curr Top Microbiol Immunol. 2001; 257: 53-83 5.","journal-title":"Curr Top Microbiol Immunol"},{"issue":"2384-2390","key":"ref_4","first-page":"6","article-title":"Staphyococcus aureus Isolates Carrying Panton-Valentine Leucocidin Genes in England and Wale: Frequency, Characterisation and Assciation with Clinical Disease","volume":"43","year":"2005","unstructured":"Staphyococcus aureus Isolates Carrying Panton-Valentine Leucocidin Genes in England and Wale: Frequency, Characterisation and Assciation with Clinical Disease. J Clin Microb. 2005; 43: 2384-2390 6.","journal-title":"J Clin Microb"},{"issue":"237-245","key":"ref_5","first-page":"7","article-title":"Epidemiological data on Staphylococcus aureus strains producing synergohymentopic toxins","volume":"42","author":"Prevost, G.; Couppie, P.; Prevost, P.","year":"1995","unstructured":"Prevost G, Couppie P, Prevost P. et al. Epidemiological data on Staphylococcus aureus strains producing synergohymentopic toxins. J Med Microbiol. 1995 42: 237-245 7. British Broadcasting Corperation. (2005) Alert after rare bug kills Marine. [online] http:\/\/news.bbc.co.uk\/1\/hi\/england\/devon\/4574613.stm.[Accessed 13 June 2009] 8. Health Protection Agency. Guidance on the diagnosis and management of PVL-associated Staphylococcus aureus infections (PVL-SA)in England, 2nd Edition. HMSO. London.2008 9.","edition":"2nd Edition","journal-title":"J Med Microbiol; Alert after rare bug kills Marine"},{"key":"ref_6","article-title":"Clonal spread of Staphylococcus aureus among soldiers in Latvian contingent in Iraq. Presented to 17th European Congress of Clinical Microbiology and Infectious Diseases, ICC","author":"Pinke, M.; Cupane, L.; Balode, A.","year":"2007","unstructured":"Pinke M, Cupane L, Balode A. et al. Clonal spread of Staphylococcus aureus among soldiers in Latvian contingent in Iraq. Presented to 17th European Congress of Clinical Microbiology and Infectious Diseases, ICC, Munich, Germany, 31 March 2007."}],"container-title":["Journal of the Royal Army Medical Corps"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jramc-155-03-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T06:25:25Z","timestamp":1716186325000},"score":1,"resource":{"primary":{"URL":"https:\/\/militaryhealth.bmj.com\/lookup\/doi\/10.1136\/jramc-155-03-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,9,1]]},"published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1136\/jramc-155-03-08"],"URL":"https:\/\/doi.org\/10.1136\/jramc-155-03-08","relation":{},"ISSN":["0035-8665","2052-0468"],"issn-type":[{"value":"0035-8665","type":"print"},{"value":"2052-0468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}