{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:46:36Z","timestamp":1755225996842,"version":"3.43.0"},"reference-count":11,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J R Army Med Corps"],"accepted":{"date-parts":[[2017,3,29]]},"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>During military deployment, the diagnosis and the management of acute bacterial meningitis can be problematic, as deployed Medical Treatment Facilities (MTFs) often have a limited laboratory diagnostic capability. However, French Role 2 and 3 MTFs have point-of-care (POC) testing to perform urinary (Multistix 10 SG strip) and blood (iSTAT handheld analyser) biochemical testing mentioned in AMedP8.5. The purpose of this study was to compare the accuracy of this urine test strip and of the iSTAT CHEM8 and CG4 cartridges with a standard hospital bench top analyser in order to determine if these POC devices have a potential role in the biochemical analysis of cerebrospinal fluid (CSF protein, CSF glucose and CSF lactate, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Agreement between the index methods and the reference methods (suitable kits on the Cobas 6 000 System) was evaluated by parallel testing of 30 CSF samples by both techniques. For CSF protein, agreement between the strip and the reference method was evaluated determining the \u03ba coefficient. For CSF glucose and CSF lactate subgroups, least squares linear regressions were calculated and Bland-Altman analyses were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The Multistix 10 SG strip can be used to make a semiquantitative determination of CSF protein. A good agreement between the strip and the reference method was observed (\u03ba coefficient: 0.93 (IC<jats:sub>95<\/jats:sub> 0.82 to 1)). This strip is thus well adapted to demonstrate an elevation of CSF protein level as observed in acute bacterial meningitis. The iSTAT CHEM8 and CG4+ cartridges correlated well with the reference methods for the determination of CSF glucose and CSF lactate, respectively (r<jats:sup>2<\/jats:sup>&gt;0.98) but exhibited a negative bias (\u223c \u22127% and \u223c \u221215%, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The combined use of the Multistix 10 SG strip and of the iSTAT system appears to be an attractive solution for the biochemical investigation of CSF in medical treatment facilities with limited laboratory diagnostic capability.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jramc-2017-000778","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T20:10:13Z","timestamp":1494533413000},"page":"397-400","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Biochemical analysis of cerebrospinal fluid in the laboratories of deployed medical treatment facilities: are Multistix 10 SG strip and iSTAT useful?"],"prefix":"10.1136","volume":"163","author":[{"given":"Bertrand","family":"Lefrere","sequence":"first","affiliation":[{"name":"D\u00e9partement des laboratoires, H\u00f4pital d'Instruction des Arm\u00e9es B\u00e9gin, Saint Mand\u00e9, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Plantamura","sequence":"additional","affiliation":[{"name":"D\u00e9partement des laboratoires, H\u00f4pital d'Instruction des Arm\u00e9es B\u00e9gin, Saint Mand\u00e9, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Renard","sequence":"additional","affiliation":[{"name":"Ecole du Val de Gr\u00e2ce, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Ceppa","sequence":"additional","affiliation":[{"name":"D\u00e9partement des laboratoires, H\u00f4pital d'Instruction des Arm\u00e9es B\u00e9gin, Saint Mand\u00e9, France"},{"name":"Ecole du Val de Gr\u00e2ce, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Delacour","sequence":"additional","affiliation":[{"name":"D\u00e9partement des laboratoires, H\u00f4pital d'Instruction des Arm\u00e9es B\u00e9gin, Saint Mand\u00e9, France"},{"name":"Ecole du Val de Gr\u00e2ce, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,5,10]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Millar BC , Moore PJ , Moore JE . Meningococcal disease: has the battle been won? J R Army Med Corp 2016. http:\/\/dx.doi.org\/10.1136\/jramc-2016\u2013000695","key":"2025081314400228000_163.6.397.1","DOI":"10.1136\/jramc-2016-000695"},{"unstructured":"NATO. AMedP-23. National Military Strategies for Vaccination of NATO Forces. December 2008. http:\/\/www.coemed.org\/images\/Courses_pdf\/stanags\/fhp\/2037_amedp-23.pdf (accessed 5 May 2017)","key":"2025081314400228000_163.6.397.2"},{"key":"2025081314400228000_163.6.397.3","doi-asserted-by":"crossref","first-page":"e1702","DOI":"10.7205\/MILMED-D-15-00448","article-title":"A fatal case of invasive infection caused by W135 Neisseria meningitidis in a vaccinated French soldier","volume":"181","author":"Duron","year":"2016","journal-title":"Mil Med"},{"key":"2025081314400228000_163.6.397.4","doi-asserted-by":"crossref","first-page":"308","DOI":"10.7205\/MILMED-D-10-00283","article-title":"U.S. military fatalities due to Neisseria meningitidis: case reports and historical perspective","volume":"176","author":"Keiser","year":"2011","journal-title":"Mil Med"},{"unstructured":"NATO. AMedP-8.5. Minimum test requirements for laboratory units of in theatre military medical treatment facilities (MTFs). Edition A Version 1. October 2013. http:\/\/www.coemed.org\/images\/Courses_pdf\/stanags\/mhc\/2571_AMedP-8.5%20EDA%20V1%20E.pdf (accessed 5 May 2017)","key":"2025081314400228000_163.6.397.5"},{"issue":"(Suppl 3)","key":"2025081314400228000_163.6.397.6","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/j.cmi.2016.01.007","article-title":"ESCMID guideline: diagnosis and treatment of acute bacterial meningitis","volume":"22","author":"van de Beek","year":"2016","journal-title":"Clin Microbiol Infect"},{"doi-asserted-by":"publisher","key":"2025081314400228000_163.6.397.7","DOI":"10.1016\/S0140-6736(95)90931-1"},{"key":"2025081314400228000_163.6.397.8","first-page":"62","article-title":"Rapid diagnosis of meningitis using reagent strips","volume":"58","author":"Parmar","year":"2004","journal-title":"Indian J Med Sci"},{"doi-asserted-by":"publisher","key":"2025081314400228000_163.6.397.9","DOI":"10.4103\/0976-3147.112737"},{"key":"2025081314400228000_163.6.397.10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4103\/0028-3886.173641","article-title":"Semi-quantitative analysis of cerebrospinal fluid chemistry and cellularity using urinary reagent strip: an aid to rapid diagnosis of meningitis","volume":"64","author":"Chikkannaiah","year":"2016","journal-title":"Neurol India"},{"doi-asserted-by":"publisher","key":"2025081314400228000_163.6.397.11","DOI":"10.1016\/j.jinf.2011.02.010"}],"container-title":["Journal of the Royal Army Medical Corps"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jramc-2017-000778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T21:40:10Z","timestamp":1755121210000},"score":1,"resource":{"primary":{"URL":"https:\/\/militaryhealth.bmj.com\/lookup\/doi\/10.1136\/jramc-2017-000778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,10]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,12,4]]},"published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1136\/jramc-2017-000778"],"URL":"https:\/\/doi.org\/10.1136\/jramc-2017-000778","relation":{},"ISSN":["0035-8665","2052-0468"],"issn-type":[{"type":"print","value":"0035-8665"},{"type":"electronic","value":"2052-0468"}],"subject":[],"published":{"date-parts":[[2017,5,10]]}}}