{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:44:56Z","timestamp":1755225896098,"version":"3.43.0"},"reference-count":11,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J R Army Med Corps"],"accepted":{"date-parts":[[2017,10,31]]},"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Providing evidence of sensitisation is the formal requirement for allergy diagnosis. The aim of this study was to evaluate whether spirometry may be able to predict sensitisation in a representative cohort of Italian Navy military personnel.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>2043 (1875 men, 168 women, mean age 28.35\u00b111.6 years) Italian Navy military personnel were enrolled into this study. Spirometry and skin prick testing were performed to predict sensitisation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Sensitisation, assessed by skin prick test, was documented in 658 (32.2%) subjects. Impaired forced expiratory flow at the 25% and 75% of the pulmonary volume (FEF<jats:sub>25\u201375<\/jats:sub>) as demonstrated on spirometry was detected in 82 subjects, of whom 69 were sensitised (P&lt;0.0001). Impaired FEF<jats:sub>25\u201375<\/jats:sub> was significantly associated with sensitisation (OR 7.43; 95% CI 4.04 to 14.66; P&lt;0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>The findings of this study suggest that impaired FEF<jats:sub>25\u201375<\/jats:sub> may predict sensitisation in this cohort of Italian Navy personnel. This outcome is relevant in the military medical setting, as it could allow early identification of subjects with subclinical asthma.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jramc-2017-000841","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T20:10:16Z","timestamp":1511554216000},"page":"58-60","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Could routine spirometry suggest sensitisation in the military medicine setting?"],"prefix":"10.1136","volume":"164","author":[{"given":"Ignazio","family":"Cirillo","sequence":"first","affiliation":[{"name":"Respiratory Medicine and Allergy, Italian Navy, La Spezia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Gallo","sequence":"additional","affiliation":[{"name":"Biostatistics Dept, Universita degli Studi di Genova Scuola di Scienze Mediche e Farmaceutiche, Genova, Liguria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-8421","authenticated-orcid":false,"given":"G","family":"Ciprandi","sequence":"additional","affiliation":[{"name":"Internal Medicine, Ospedale Policlinico San Martino, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"2025081312494745000_164.1.58.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"2025081312494745000_164.1.58.2","first-page":"220","article-title":"Inflammatory issues in allergic rhinitis and asthma","volume":"26","author":"Frieri","year":"2005","journal-title":"Allergy Asthma Proc"},{"key":"2025081312494745000_164.1.58.3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2025081312494745000_164.1.58.4","unstructured":"Global Initiative for Asthma. GINA guidelines. global strategy for asthma management and prevention. htpp:\/\/www.ginasthma.org\/ (accessed Jul 2017)."},{"key":"2025081312494745000_164.1.58.5","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jaci.2010.10.053","article-title":"FEF25-75 may be a marker of bronchial impairment in allergic rhinitis","volume":"127","author":"Ciprandi","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"2025081312494745000_164.1.58.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.02.009"},{"key":"2025081312494745000_164.1.58.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.029"},{"key":"2025081312494745000_164.1.58.8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000443797","article-title":"Association of FEF25-75% impairment with bronchial hyperresponsiveness and airway inflammation in subjects with asthma-like symptoms","volume":"91","author":"Malerba","year":"2016","journal-title":"Respiration"},{"key":"2025081312494745000_164.1.58.9","first-page":"S15","article-title":"Impaired spirometry may suggest sensitization","volume":"26","author":"Ciprandi","year":"2012","journal-title":"J Biol Regul Homeost Agents"},{"key":"2025081312494745000_164.1.58.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1989.tb00438.x"},{"key":"2025081312494745000_164.1.58.11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2500\/ajra.2011.25.3652","article-title":"Spirometric abnormalities in patients with allergic rhinitis: Indicator of an \"asthma march\"?","volume":"25","author":"Ciprandi","year":"2011","journal-title":"Am J Rhinol Allergy"}],"container-title":["Journal of the Royal Army Medical Corps"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jramc-2017-000841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T19:49:55Z","timestamp":1755114595000},"score":1,"resource":{"primary":{"URL":"https:\/\/militaryhealth.bmj.com\/lookup\/doi\/10.1136\/jramc-2017-000841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,2,1]]},"published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1136\/jramc-2017-000841"],"URL":"https:\/\/doi.org\/10.1136\/jramc-2017-000841","relation":{},"ISSN":["0035-8665","2052-0468"],"issn-type":[{"type":"print","value":"0035-8665"},{"type":"electronic","value":"2052-0468"}],"subject":[],"published":{"date-parts":[[2017,11,24]]}}}