{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:06:38Z","timestamp":1788948398427,"version":"build-2803163510"},"reference-count":45,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"unspecified","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Scleroderma Relat Disord"],"accepted":{"date-parts":[[2025,11,13]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore variations in disease presentation between isolated systemic sclerosis (SSc), primary biliary cholangitis (PBC) and SSc\u2013PBC overlap syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Systematic review conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Literature search of PubMed, Scopus and Google Scholar for studies published through June 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>13 studies (from 1331 initially identified records) including patients with isolated SSc, isolated PBC and SSc\u2013PBC overlap were included. Eligible studies were case\u2013control or cohort designs reporting demographic, serological or clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Differences in clinical phenotype, serological markers, systemic involvement and mortality between SSc\u2013PBC overlap and isolated disease groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with SSc\u2013PBC overlap demonstrated distinct clinical characteristics compared with isolated disease phenotypes. Anticentromere antibody and antimitochondrial antibody positivity were significantly higher in overlap patients. The overlap group predominantly included patients with limited cutaneous SSc and had a higher prevalence of extrahepatic autoimmune diseases, particularly Sj\u00f6gren\u2019s syndrome and Hashimoto\u2019s thyroiditis. Systemic involvement, including pulmonary, musculoskeletal and cardiac manifestations, was less pronounced in overlap patients compared with isolated SSc. Liver-related mortality was higher in the PBC-only group, whereas mortality in the overlap group was primarily attributable to SSc-related causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SSc\u2013PBC overlap syndrome represents a distinct clinical and immunological entity. Recognition of this phenotype may facilitate earlier diagnosis, guide management strategies and improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jsrd-2026-000002","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:50:18Z","timestamp":1779803418000},"page":"e000002","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic sclerosis and primary biliary cholangitis: a systematic review of case\u2013control studies comparing isolated and overlapping disease phenotypes"],"prefix":"10.1136","volume":"11","author":[{"given":"Meryem","family":"Nursoy","sequence":"first","affiliation":[{"name":"Hull University Teaching Hospitals NHS Trust, Hull, 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