{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:58:21Z","timestamp":1793069901949,"version":"4.5.0"},"reference-count":15,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2016,11,5]]},"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To provide an estimate of age-specific incidence rate of physician-diagnosed systemic lupus erythematosus (SLE) for German men and women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The age-specific and sex-specific prevalence of diagnosed SLE in claims data is used to estimate the incidence in the German male and female population. The claims data set stems from a representative sample of the statutory health insurance in 2002 and comprises 2.3 million people. The statutory health insurance covers &gt;85% of the German population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The estimated incidence rates are 0.9 (95% CI 0.7 to 1.1) per 100\u2005000 person-years for men and 1.9 (95% CI 1.7 to 2.2) per 100\u2005000 person-years for women. The age-specific incidence rate of SLE in the male population has a maximum of 2.2 (95% CI 1.0 to 3.4) per 100\u2005000 person-years at the age of 65\u201370\u2005years. In women, the incidence is peaking at the rate of 3.6 (95% CI 2.9 to 4.3) cases per 100\u2005000 person-years at the age of 20\u201325\u2005years, but has a second local maximum (2.6, 95% CI 1.5 to 3.8) at menopausal age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>For the first time, representative data on the incidence of SLE in Germany are provided. The estimated incidence rates of SLE for men and women in Germany are at the lower end of other estimates from comparable European countries.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/lupus-2016-000181","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T21:10:35Z","timestamp":1480108235000},"page":"e000181","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Age-specific and sex-specific incidence of systemic lupus erythematosus: an estimate from cross-sectional claims data of 2.3 million people in the German statutory health insurance 2002"],"prefix":"10.1136","volume":"3","author":[{"given":"Ralph","family":"Brinks","sequence":"first","affiliation":[{"name":"Hiller Research Unit for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"},{"name":"German Diabetes Center, Institute for Biometry and Epidemiology, Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Hoyer","sequence":"additional","affiliation":[{"name":"German Diabetes Center, Institute for Biometry and Epidemiology, Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergej","family":"Weber","sequence":"additional","affiliation":[{"name":"Hiller Research Unit for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Fischer-Betz","sequence":"additional","affiliation":[{"name":"Hiller Research Unit for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"},{"name":"Policlinics for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Sander","sequence":"additional","affiliation":[{"name":"Hiller Research Unit for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"},{"name":"Policlinics for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta G","family":"Richter","sequence":"additional","affiliation":[{"name":"Hiller Research Unit for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"},{"name":"Policlinics for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal","family":"Chehab","sequence":"additional","affiliation":[{"name":"Hiller Research Unit for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"},{"name":"Policlinics for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schneider","sequence":"additional","affiliation":[{"name":"Hiller Research Unit for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"},{"name":"Policlinics for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,11,25]]},"reference":[{"key":"2025091515200765000_3.1.e000181.1","unstructured":"Hennekens CH , Buring JE , Mayrent SL . Epidemiology in medicine. New York, NY: Little, Brown and Company, 1987."},{"key":"2025091515200765000_3.1.e000181.2","doi-asserted-by":"publisher","DOI":"10.2307\/2983150"},{"key":"2025091515200765000_3.1.e000181.3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tpb.2013.11.006","article-title":"Age- and time-dependent model of the prevalence of non-communicable diseases and application to dementia in Germany","volume":"92","author":"Brinks","year":"2014","journal-title":"Theo Popul Biol"},{"key":"2025091515200765000_3.1.e000181.4","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5651"},{"key":"2025091515200765000_3.1.e000181.5","unstructured":"Lugert P . Stichprobendaten von Versicherten der gesetzlichen Krankenversicherung 2007:Arbeitspapier 22, Federal Statistical Office of Germany, Wiesbaden http:\/\/www.forschungsdatenzentrum.de\/publikationen\/veroeffentlichungen\/22.asp (accessed May 2016)."},{"key":"2025091515200765000_3.1.e000181.6","unstructured":"Federal Ministry of Health. Gesetzliche Krankenversicherung Mitglieder und mitversicherte Angeh\u00f6rige nach Altersgruppen, 2005. http:\/\/www.bundesgesundheitsministerium.de\/fileadmin\/redaktion\/pdf_statistiken\/krankenversicherung\/Versicherte-1992-2004-pdf-6849.pdf (accessed May 2016)."},{"key":"2025091515200765000_3.1.e000181.7","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314540352"},{"key":"2025091515200765000_3.1.e000181.8","unstructured":"Federal Statistical Office of Germany, Bev\u00f6lkerung Deutschland. https:\/\/www-genesis.destatis.de\/genesis\/online\/link\/tabellen\/12411* (accessed May 2016)."},{"key":"2025091515200765000_3.1.e000181.9","unstructured":"Deutsches Rheuma-Forschungszentrum, Daten der Kerndokumentation 2014, http:\/\/www.drfz.de\/wp-content\/uploads\/Ergebnisse_Kerndokumentation_2014.pdf, Slide 12 (accessed Jun 2016)."},{"key":"2025091515200765000_3.1.e000181.10","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316644333"},{"key":"2025091515200765000_3.1.e000181.11","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.autrev.2014.08.034","article-title":"Prevalence and incidence of systemic lupus erythematosus in France: a 2010 nation-wide population-based study","volume":"13","author":"Arnaud","year":"2014","journal-title":"Autoimm Rev"},{"key":"2025091515200765000_3.1.e000181.12","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/art.22683","article-title":"Incidence of systemic lupus erythematosus in the United Kingdom, 1990\u20131999","volume":"57","author":"Somers","year":"2007","journal-title":"Arthrit Care Res"},{"key":"2025091515200765000_3.1.e000181.13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1119384"},{"key":"2025091515200765000_3.1.e000181.14","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/sim.6736","article-title":"A comparative study of prevalence-based incidence estimation techniques with application to dementia data in Germany","volume":"35","author":"Landwehr","year":"2016","journal-title":"Statist Med"},{"key":"2025091515200765000_3.1.e000181.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60879-9"}],"container-title":["Lupus Science &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/lupus-2016-000181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:20:15Z","timestamp":1757974815000},"score":1,"resource":{"primary":{"URL":"https:\/\/lupus.bmj.com\/lookup\/doi\/10.1136\/lupus-2016-000181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,11,25]]},"published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1136\/lupus-2016-000181"],"URL":"https:\/\/doi.org\/10.1136\/lupus-2016-000181","relation":{},"ISSN":["2053-8790"],"issn-type":[{"value":"2053-8790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11]]}}}