{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:49:29Z","timestamp":1792381769468,"version":"4.4.0"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2017,2,14]]},"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Subacute cutaneous lupus erythematosus (SCLE) is a well-defined subtype of lupus erythematosus, characterised by photosensitivity, annular and\/or psoriasiform lesions, variable systemic involvement and presence of circulating SSA\/anti-Ro antibodies. SCLE may be idiopathic or drug-induced. Both the idiopathic and drug-induced forms of SCLE are analogous in their clinical, serological and histological features. Drug-induced SCLE has been reported with various oral agents, but to our knowledge this is the first reported case due to a topical medication. A 34-year-old female foot masseuse presented with a 2-month history of scaly, erythematous lesions isolated to the dorsal hands and interdigital spaces. She had used topical terbinafine, a topical antifungal cream, to her clients\u2019 feet for a number of years. ANA and anti-SSA\/Ro antibodies were positive. Physical examination, serology and histopathology were consistent with SCLE. We propose that our patient's unique presentation of SCLE may be explained by a prolonged occupational exposure to topical terbinafine as a foot masseuse. While oral terbinafine is a drug known to cause drug-induced SCLE, to our knowledge, this is the first topically induced form of the disease.<\/jats:p>","DOI":"10.1136\/lupus-2017-000207","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T20:47:37Z","timestamp":1489438057000},"page":"e000207","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands"],"prefix":"10.1136","volume":"4","author":[{"given":"Sarika M","family":"Ramachandran","sequence":"first","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S","family":"Leventhal","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren G","family":"Franco","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Mir","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth F","family":"Walters","sequence":"additional","affiliation":[{"name":"The Ronald O. 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Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA"},{"name":"Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"2025091513502294000_4.1.e000207.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.01.003"},{"key":"2025091513502294000_4.1.e000207.2","first-page":"465","article-title":"A systematic review of drug-induced subacute cutaneous lupus erythematosus","volume":"164","author":"Lowe","year":"2011","journal-title":"Br J Dermatol"},{"key":"2025091513502294000_4.1.e000207.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02013.x"},{"key":"2025091513502294000_4.1.e000207.4","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0190-9622(88)70259-5","article-title":"Resistant discoid lupus erythematosus of palms and soles: successful treatment with azathioprine","volume":"19","author":"Ashinoff","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"2025091513502294000_4.1.e000207.5","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197603000-00006"},{"key":"2025091513502294000_4.1.e000207.6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1610-0387.2008.06806.x","article-title":"Subacute cutaneous lupus erythematosus induced by terbinafine: case report and review of literature","volume":"6","author":"Lorentz","year":"2008","journal-title":"J Dtsch Dermatol Ges"},{"key":"2025091513502294000_4.1.e000207.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10397.x"},{"key":"2025091513502294000_4.1.e000207.8","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.45"},{"key":"2025091513502294000_4.1.e000207.9","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1111\/j.1365-2230.2009.03380.x","article-title":"Subacute cutaneous lupus erythematosus associated with terbinafine","volume":"34","author":"Kasperkiewicz","year":"2009","journal-title":"Clin Exp Dermatol"},{"key":"2025091513502294000_4.1.e000207.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00461.x"},{"key":"2025091513502294000_4.1.e000207.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1962.tb13504.x"},{"key":"2025091513502294000_4.1.e000207.12","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-0031-x"},{"key":"2025091513502294000_4.1.e000207.13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00118.x"}],"container-title":["Lupus Science &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/lupus-2017-000207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T20:50:28Z","timestamp":1757969428000},"score":1,"resource":{"primary":{"URL":"https:\/\/lupus.bmj.com\/lookup\/doi\/10.1136\/lupus-2017-000207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,3,13]]},"published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1136\/lupus-2017-000207"],"URL":"https:\/\/doi.org\/10.1136\/lupus-2017-000207","relation":{},"ISSN":["2053-8790"],"issn-type":[{"value":"2053-8790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}