{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T21:21:40Z","timestamp":1758057700132,"version":"3.44.0"},"reference-count":38,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2018,10,26]]},"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>SLE is an autoimmune condition affecting predominantly women. Little is known regarding <jats:italic>Chlamydia trachomatis<\/jats:italic> infection in women with SLE, which may drive autoimmunity and contribute to obstetrical and vascular complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This single-centre, case\u2013control study set primary endpoint in the comparative seropositivity rate to <jats:italic>C. trachomatis<\/jats:italic> major outer membrane protein (MOMP) and chlamydial heat-shock protein-60 (cHSP60) in age-matched subjects. The secondary endpoints were obstetrical outcomes, cardiovascular events and results from screening procedures for cervical cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eighty-four women with SLE and 50 age-matched controls were included. Seropositivity to <jats:italic>C. trachomatis<\/jats:italic> did not differ significantly between groups (10% of cases positive for anti-MOMP vs 12% of controls; 43% of cases positive for anti-cHSP60 vs 32% of controls). Women with SLE were more often of non-Caucasian ethnicity and had lower educational level. They relied less frequently on oral contraception and resorted more frequently to elective pregnancy termination. Pre-eclampsia and ectopic pregnancy occurred only in SLE. Women with SLE also experienced more cardiovascular events. In SLE, antibodies to cHSP60 were associated with a history of pericarditis and abnormal screening tests for cervical cancer. Antibody titres to <jats:italic>C. trachomatis<\/jats:italic> were not associated with disease activity or SLE treatment, nor were there associations with other gynaecological, obstetrical or vascular outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Prevalence of antibodies to <jats:italic>C. trachomatis<\/jats:italic> was not increased in women with SLE. No significant association was found between these antibodies and obstetrical or cardiovascular complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/lupus-2018-000293","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T23:15:19Z","timestamp":1542842119000},"page":"e000293","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Antibodies to <i>Chlamydia trachomatis<\/i> and reproductive health issues in women with SLE: a case\u2013control study"],"prefix":"10.1136","volume":"5","author":[{"given":"Alba","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Greub","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Aeby","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Wunder","sequence":"additional","affiliation":[{"name":"Reproductive Medicine, Department of Obstetrics and Gynecology, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Pantaleo","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0446-9741","authenticated-orcid":false,"given":"Camillo","family":"Ribi","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"key":"2025091515144715000_5.1.e000293.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.11.002"},{"key":"2025091515144715000_5.1.e000293.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050817"},{"key":"2025091515144715000_5.1.e000293.3","doi-asserted-by":"crossref","unstructured":"Rojas-Villarraga A , Torres-Gonzalez JV , Ruiz-Sternberg \u00c1M . 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