{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:52:41Z","timestamp":1790297561571,"version":"4.1.0"},"reference-count":66,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"unspecified","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2022,11,12]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Fertility is often a concern for women with SLE. In addition to known indirect factors that influence the ability of a woman with SLE to become pregnant, such as cytotoxic agents, other medications, advanced age and psychosocial effects of the disease, direct disease-related factors are believed to influence fertility. These include diminished ovarian reserve, menstrual irregularities (a function of disease activity) and the presence of antiphospholipid antibodies. The question of whether SLE intrinsically affects fertility, however, remains unanswered. In this review, we address known factors affecting fertility, assess current data regarding a direct impact of SLE on fertility and evaluate potential disease-related risk factors. We focus primarily on studies measuring anti-M\u00fcllerian hormone and antral follicle count, the most widely measured markers of ovarian reserve. Our goal is to provide information to rheumatologists faced with counselling patients with SLE regarding their fertility, family planning and options for assisted reproductive technologies, which now include fertility preservation through oocyte cryopreservation.<\/jats:p>","DOI":"10.1136\/lupus-2022-000840","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T11:03:40Z","timestamp":1670929420000},"page":"e000840","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology"],"prefix":"10.1136","volume":"9","author":[{"given":"Bessie","family":"Stamm","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Hospital for Special Surgery-Weill Cornell Medicine, New York, NY, USA"},{"name":"Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medha","family":"Barbhaiya","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Hospital for Special Surgery-Weill Cornell Medicine, New York, NY, USA"},{"name":"Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, New York, NY, USA"},{"name":"Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Hospital for Special Surgery-Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lieber","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Hospital for Special Surgery-Weill Cornell Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lockshin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Hospital for Special Surgery-Weill Cornell Medicine, New York, NY, USA"},{"name":"Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2387-5363","authenticated-orcid":false,"given":"Lisa","family":"Sammaritano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Hospital for Special Surgery-Weill Cornell Medicine, New York, NY, USA"},{"name":"Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"2025091513503552000_9.1.e000840.1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/art.41191","article-title":"2020 American College of Rheumatology guideline for the management of reproductive health in rheumatic and musculoskeletal diseases","volume":"72","author":"Sammaritano","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"2025091513503552000_9.1.e000840.2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314527370"},{"key":"2025091513503552000_9.1.e000840.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.03.012"},{"key":"2025091513503552000_9.1.e000840.4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ogc.2012.09.001","article-title":"Infertility evaluation","volume":"39","author":"McLaren","year":"2012","journal-title":"Obstet Gynecol Clin North Am"},{"key":"2025091513503552000_9.1.e000840.5","first-page":"1","article-title":"Recent advances in medically assisted conception. 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