{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:59:45Z","timestamp":1781711985929,"version":"3.54.5"},"reference-count":21,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2024,3,22]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To develop an improved score for prediction of severe infection in patients with systemic lupus erythematosus (SLE), namely, the SLE Severe Infection Score-Revised (SLESIS-R) and to validate it in a large multicentre lupus cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used data from the prospective phase of RELESSER (RELESSER-PROS), the SLE register of the Spanish Society of Rheumatology. A multivariable logistic model was constructed taking into account the variables already forming the SLESIS score, plus all other potential predictors identified in a literature review. Performance was analysed using the C-statistic and the area under the receiver operating characteristic curve (AUROC). Internal validation was carried out using a 100-sample bootstrapping procedure. ORs were transformed into score items, and the AUROC was used to determine performance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1459 patients who had completed 1 year of follow-up were included in the development cohort (mean age, 49\u00b113 years; 90% women). Twenty-five (1.7%) had experienced \u22651 severe infection. According to the adjusted multivariate model, severe infection could be predicted from four variables: age (years) \u226560, previous SLE-related hospitalisation, previous serious infection and glucocorticoid dose. A score was built from the best model, taking values from 0 to 17. The AUROC was 0.861 (0.777\u20130.946). The cut-off chosen was \u22656, which exhibited an accuracy of 85.9% and a positive likelihood ratio of 5.48.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SLESIS-R is an accurate and feasible instrument for predicting infections in patients with SLE. SLESIS-R could help to make informed decisions on the use of immunosuppressants and the implementation of preventive measures.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/lupus-2023-001096","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T13:20:19Z","timestamp":1712582419000},"page":"e001096","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["SLESIS-R: an improved score for prediction of serious infection in patients with systemic lupus erythematosus based on the RELESSER prospective cohort"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7894-1690","authenticated-orcid":false,"given":"I\u00f1igo","family":"Rua-Figueroa","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Jesus","family":"Garc\u00eda de Y\u00e9benes","sequence":"additional","affiliation":[{"name":"Institute for Musculoskeletal Health, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Martinez-Barrio","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Galindo Izquierdo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9378-8412","authenticated-orcid":false,"given":"Jaime","family":"Calvo Al\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Sierrallana, Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-9844","authenticated-orcid":false,"given":"Antonio","family":"Fernandez-Nebro","sequence":"additional","affiliation":[{"name":"UGC de Reumatolog\u00eda, Hospital Regional Universitario de M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Menor-Almagro","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Jerez Hospital, Jerez, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-2551","authenticated-orcid":false,"given":"Loreto","family":"Carmona","sequence":"additional","affiliation":[{"name":"Instituto de Salud Musculoesquel\u00e9tica (INMUSC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Tejera Segura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Tomero","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario de la Princesa, Instituto de Investigaci\u00f3n La Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Freire-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Complex of A Coru\u00f1a, A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Sang\u00fcesa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Germ\u00e1n Trias i Pujol, Barcelona, 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