{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:19:23Z","timestamp":1782951563220,"version":"3.54.5"},"reference-count":50,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"unspecified","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["311161"],"award-info":[{"award-number":["311161"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2025,1,15]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Patients with SLE take multiple medications. Within a large prospective longitudinal SLE cohort, we characterised medication-related hospitalisations and their preventability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We identified consecutive admissions to our tertiary hospitals between 2015 and 2020. Two independent adjudicators evaluated if medication-related events contributed to the hospitalisation, considering (1) adverse drug events (ADEs) and (2) events from medication non-adherence, using the Leape and Bates method. We classified ADEs as potentially preventable\/ameliorable if we identified modifiable factors. Logistic regressions with generalised estimating equations evaluated associations between participant characteristics and medication-related hospitalisations, accounting for repeat hospitalisations within the same participant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We studied 68 hospitalisations among 45 participants (91% female). At first hospitalisation, the median age was 38 years (IQR 26.5\u201353.0) and median SLE duration was 12 years (IQR 5.5\u201319.5). One or more ADEs contributed to 20 (29%) hospitalisations (11\/23 (48%) ADEs being preventable\/ameliorable), and SLE flares associated with medication non-adherence contributed to 7 (10%) hospitalisations. Adjusting for age and sex, current prednisone use (adjusted OR (aOR) 3.7, 95%\u2009CI 1.1 to 13.0) or \u22651 current immunosuppressant (aOR 11.5, 95%\u2009CI 2.7 to 50.0), renal involvement at SLE diagnosis (aOR 6.5, 95%\u2009CI 2.7 to 15.7) and polypharmacy (\u22655 medications; aOR 11.3, 95%\u2009CI 1.2 to 103.8) were associated with having an ADE-related (vs non-ADE) hospitalisation. Age at SLE diagnosis&lt;18 years (OR 5.9, 95%\u2009CI 1.3 to 26.6) was associated with hospitalisation for a flare related to non-adherence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Forty per cent of SLE hospitalisations were medication-related, while half were potentially preventable\/ameliorable. Renal involvement, polypharmacy, prednisone and immunosuppressant use were associated with hospitalisation related to an ADE, highlighting a vulnerable group.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/lupus-2024-001362","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T10:00:11Z","timestamp":1738231211000},"page":"e001362","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Medication-related hospitalisations in patients with SLE"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1547-7220","authenticated-orcid":false,"given":"Mich\u00e8le","family":"Stanciu","sequence":"first","affiliation":[{"name":"McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Young Esther","family":"Lee","sequence":"additional","affiliation":[{"name":"Centre for Outcomes Research and Evaluation 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