{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:20:06Z","timestamp":1792819206597,"version":"4.5.0"},"reference-count":35,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Sichuan Provincial People's Hospital","award":["2017QN12"],"award-info":[{"award-number":["2017QN12"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2025,1,1]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>SLE is a multifaceted autoimmune disorder with a complex pathogenesis involving genetic, environmental and hormonal factors, which converge on immune dysregulation. The T cell receptor (TCR) repertoire\u2019s role in SLE has garnered significant interest due to its potential in both diagnostics and therapeutics. Our study aimed to delineate the variances in the TCR\u03b2 repertoire between patients with SLE and healthy individuals, correlating these differences with the severity and subtypes of SLE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted an analysis of blood samples from 50 treatment-naive patients with SLE and 50 healthy donors, employing RNA extraction, high-throughput sequencing and subsequent bioinformatics analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our findings revealed significant alterations in TRBV and TRBJ gene usage frequencies, indicative of a skewed TCR repertoire in patients with SLE. Notably, nine hub TRBV genes were identified as potential biomarkers for SLE with high diagnostic accuracy. Furthermore, we observed a reduction in TCR diversity, characterised by a lower diversity 50 value and increased clonal expansion, which correlated with disease severity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The TCR\u03b2 repertoire is significantly altered in SLE, with potential implications for diagnostics and therapeutics. The identified hub genes may serve as novel biomarkers for SLE, and the findings contribute to the understanding of the immunopathogenesis of the disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/lupus-2024-001384","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T01:15:42Z","timestamp":1737335742000},"page":"e001384","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Unravelling the TCR\u03b2 repertoire: a key to unlocking the immunopathogenesis and precision medicine in SLE"],"prefix":"10.1136","volume":"12","author":[{"given":"Li","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"},{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"},{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzuo","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First People\u2019s Hospital of Guiyang, Guiyang, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"An","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengming","family":"He","sequence":"additional","affiliation":[{"name":"Department of Technology, Chengdu ExAb Biotechnology, Ltd, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueping","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Technology, Chengdu ExAb Biotechnology, Ltd, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoping","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Technology, Chengdu ExAb Biotechnology, Ltd, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2666-2283","authenticated-orcid":false,"given":"Qiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"},{"name":"Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"},{"name":"Qionglai Medical Center Hospital, Qionglai, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"2025091514544740000_12.1.e001384.1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-043021-032611"},{"key":"2025091514544740000_12.1.e001384.2","doi-asserted-by":"crossref","DOI":"10.3390\/biom11070928","article-title":"Clinical and Immunological Biomarkers for Systemic Lupus Erythematosus","volume":"11","author":"Yu","year":"2021","journal-title":"Biomolecules"},{"key":"2025091514544740000_12.1.e001384.3","doi-asserted-by":"publisher","DOI":"10.7326\/AITC202006020"},{"key":"2025091514544740000_12.1.e001384.4","first-page":"1192","article-title":"Chinese SLE Treatment and Research group (CSTAR) registry: I. 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