{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:16:42Z","timestamp":1784913402533,"version":"3.55.0"},"reference-count":32,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"unspecified","delay-in-days":117,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","award":["FIPE\/HCPA 2020\u20130576"],"award-info":[{"award-number":["FIPE\/HCPA 2020\u20130576"]}],"id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Scholarship for the main author of one thousand an"],"award-info":[{"award-number":["Scholarship for the main author of one thousand an"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundo de Apoio \u00e0 Pesquisa da Sociedade de Reumatologia do Rio Grande do Sul"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["INCT\/CNPq 465482\/2014\u20137"],"award-info":[{"award-number":["INCT\/CNPq 465482\/2014\u20137"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2025,4,5]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess the prevalence of sarcopenia and examine its association with clinical features, health-related quality of life (HRQoL), muscle-specific strength and body composition in patients with systemic lupus erythematosus (SLE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this cross-sectional multicentre study, women with SLE (18\u201350 years old) were included. Data collected included clinical features and HRQoL. Muscle strength was assessed using the handgrip test (kg), appendicular skeletal muscle mass index (ASMI, kg\/m\u00b2) was measured using dual-energy X-ray absorptiometry. Physical performance was assessed using the timed-up-and-go test (TUG, seconds). Sarcopenia was defined by the European Working Group on Sarcopenia in Older People-2 criteria. The muscle-specific strength was evaluated by dividing their arm strength by their lean arm mass. Pearson\u2019s or Spearman\u2019s correlation coefficients were performed (accepted at p&lt;0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventy-three SLE women were included, with median (IQR) age and disease duration of 37 (30\u201344) years old and 10.0 (4.0\u201316.8) years, respectively. Most of the patients (83.5%) had inactive or low disease activity and 31.0% presented a disease damage index score \u22651. Mean (\u00b1SD) handgrip strength, ASMI and muscle-specific strength was 25.58\u00b18.31 kg, 6.62\u00b10.97 kg\/m\u00b2 and 6.6\u00b12.3, respectively. Median TUG was 6.9 (6.1\u20138.2) s. The prevalence of probable sarcopenia was 11.1%, and sarcopenia was 2.7%. Lower muscle strength, lower muscle-specific strength and lower physical performance, as well as sarcopenia, were correlated with worse HRQoL (p&lt;0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In Brazilian patients with SLE with inactive or low disease activity, the prevalence of sarcopenia was low. However, low muscle strength, low muscle-specific strength and low physical performance were correlated with worse HRQoL, emphasising the need for muscle strength assessments in SLE management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/lupus-2024-001447","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T08:10:13Z","timestamp":1745827813000},"page":"e001447","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of sarcopenia and its association with clinical features and health-related quality of life in Brazilian women with systemic lupus erythematosus"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0864-683X","authenticated-orcid":false,"given":"Emerson","family":"Pena","sequence":"first","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"},{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Peterson dos Santos","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"},{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela","family":"Cavalheiro do Esp\u00edrito Santo","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"},{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"},{"name":"Klaipeda University, Klaipeda, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Denardi","family":"D\u00f3ria","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"},{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Pilotti","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"},{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Luiz Silveira","family":"Mallmann","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"},{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"N\u00f3brega de Moraes","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"},{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice Moura","family":"Mata Machado","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"},{"name":"Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Costa Duarte Lanna","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"},{"name":"Locomotor System Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivio Brito","family":"Malheiro","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanoel Luis","family":"da Silveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Belo Horizonte, 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Hax","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"},{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poli Mara","family":"Spritzer","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"},{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayane Muniz","family":"Fighera","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil"},{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Mendon\u00e7a da 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Sarcopenia em pacientes com L\u00fapus Eritematoso Sist\u00eamico: Um estudo transversal. 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