{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:01:23Z","timestamp":1789441283533,"version":"build-2803163510"},"reference-count":41,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"unspecified","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260344"],"award-info":[{"award-number":["82260344"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2025,6,21]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess brain grey matter alterations in patients with SLE and their correlation with neuropsychological testing using synthetic MRI (SyMRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study enrolled patients with SLE and age, gender and education-matched healthy controls (HC). Study assessments included brain MRI using SyMRI and neuropsychological tests: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Digit Span Test, Self-Rating Anxiety Scale and Self-Rating Depression Scale (SDS). SyMRI post-processing and Automated Anatomical Labeling were used for grey matter mapping. Correlation analysis was performed to assess the relationship between brain grey matter structural alterations and neuropsychological testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>77 patients with SLE (57 non-neuropsychiatric SLE (non-NPSLE), 20 NPSLE) and 29 HC participants were enrolled. Patients with SLE showed reduced grey matter volume compared with HC (p&lt;0.05). The NPSLE group exhibited more extensive increases in longitudinal (T1) and transverse (T2) relaxation times in grey matter than the non-NPSLE group (p&lt;0.001). Proton density values were lower in patients with SLE (p&lt;0.001). Lower brain parenchymal volume correlated with higher SLE Disease Activity Index (p&lt;0.05). Lower MMSE\/MoCA scores correlated with increased T1\/T2 in the left medial cingulate and paracingulate gyri (p&lt;0.05). Higher SDS scores correlated with increased T1\/T2 in the left calcarine fissure and surrounding cortex (p&lt;0.05). These changes were also linked to disease markers (C3, C4, immunoglobulin M, erythrocyte sedimentation rate) (p&lt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Grey matter alterations in patients with SLE correlate with cognitive impairment, depression and disease activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/lupus-2025-001505","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:45:34Z","timestamp":1752464734000},"page":"e001505","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Assessing grey matter structural alterations in systemic lupus erythematosus using synthetic MRI"],"prefix":"10.1136","volume":"12","author":[{"given":"Kemei","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated 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