{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:40:35Z","timestamp":1771504835162,"version":"3.50.1"},"reference-count":27,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2025,7,1]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our primary objective was to estimate an updated prevalence of SLE in France in 2020. We also explore the sociodemographic characteristics of patients with SLE, the social and spatial variability and also study and use hydroxychloroquine prescription patterns as an external validation for case ascertainment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the French national health data system, which covers almost all of the 67\u2009million people living in France. Prevalent cases were identified among inpatients and people granted a long-term disease status, using the International Classification of Diseases, 10th Revision code for SLE. Filled prescriptions of hydroxychloroquine were also counted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2020, we identified 54\u2009804 patients with SLE; this corresponds to an overall prevalence of 81.6 per 100\u2009000 people. The prevalence estimates were 137.0 per 100\u2009000 in women and 22.5 per 100\u2009000 in men. The highest standardised prevalences were observed in the French overseas departments and in the mainland departments to which people from these departments frequently migrate. Unexpectedly, we did not find an association between the prevalence of SLE in mainland France and a social deprivation index. A prescription of hydroxychloroquine was filled at least once for 67.7% of the patients overall and reached 86.7% of those aged between 20 and 24.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study provides recent, accurate estimates of the prevalence and social and geographical distribution of SLE in France. We observed an almost twofold increase in prevalence, relative to a previous estimate (from 2010) based on the same database. The high proportion of patients receiving a prescription of hydroxychloroquine is in line with current treatment guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/lupus-2025-001519","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T04:10:14Z","timestamp":1753243814000},"page":"e001519","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence, sociodemographic characteristics and spatial distribution of systemic lupus erythematosus in France: a nationwide study using health claims data with insights into hydroxychloroquine prescription patterns"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9111-0576","authenticated-orcid":false,"given":"Jacques","family":"Pouchot","sequence":"first","affiliation":[{"name":"Internal Medicine, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique\u2014H\u00f4pitaux de Paris, Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Mandereau-Bruno","sequence":"additional","affiliation":[{"name":"Sant\u00e9 publique France, Saint-Maurice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Serra","sequence":"additional","affiliation":[{"name":"Sant\u00e9 publique France, Saint-Maurice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Tangre","sequence":"additional","affiliation":[{"name":"French National Health Insurance, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panayotis","family":"Constantinou","sequence":"additional","affiliation":[{"name":"French National Health Insurance, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00ebl","family":"Coste","sequence":"additional","affiliation":[{"name":"Sant\u00e9 publique France, Saint-Maurice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"2026010700552883000_12.2.e001519.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.2315"},{"key":"2026010700552883000_12.2.e001519.2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/acr.21820","article-title":"Prevalence and incidence in patients with autoimmune rheumatic diseases: A nationwide population\u2010based study in Taiwan","volume":"65","author":"Yu","year":"2013","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2026010700552883000_12.2.e001519.3","first-page":"1407","article-title":"Age-specific prevalence of diagnosed systemic lupus erythematosus in Germany 2002 and projection to 2030","volume":"23","author":"Brinks","year":"2014","journal-title":"Lupus (Los Angel)"},{"key":"2026010700552883000_12.2.e001519.4","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20120204"},{"key":"2026010700552883000_12.2.e001519.5","first-page":"1377","article-title":"Identification of patients with systemic lupus erythematosus in administrative healthcare databases","volume":"23","author":"Hanly","year":"2014","journal-title":"Lupus (Los Angel)"},{"key":"2026010700552883000_12.2.e001519.6","doi-asserted-by":"crossref","first-page":"K62","DOI":"10.1016\/j.vaccine.2013.06.104","article-title":"A systematic review of validated methods for identifying systemic lupus erythematosus (SLE) using administrative or claims data","volume":"31 Suppl 10","author":"Moores","year":"2013","journal-title":"Vaccine (Auckl)"},{"key":"2026010700552883000_12.2.e001519.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.034"},{"key":"2026010700552883000_12.2.e001519.8","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224762"},{"key":"2026010700552883000_12.2.e001519.9","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1016\/j.respe.2017.05.004","article-title":"Value of a national administrative database to guide public decisions: From the syst\u00e8me national d\u2019information interr\u00e9gimes de l\u2019Assurance Maladie (SNIIRAM) to the syst\u00e8me national des donn\u00e9es de sant\u00e9 (SNDS) in France","volume":"65 Suppl 4","author":"Tuppin","year":"2017","journal-title":"Rev Epidemiol Sante Publique"},{"key":"2026010700552883000_12.2.e001519.10","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-9-33","article-title":"Ecological association between a deprivation index and mortality in France over the period 1997 - 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