{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T13:11:54Z","timestamp":1767791514381,"version":"3.49.0"},"reference-count":15,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":92,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013018","name":"Hospital for Special Surgery","doi-asserted-by":"publisher","award":["Fund for the Future"],"award-info":[{"award-number":["Fund for the Future"]}],"id":[{"id":"10.13039\/100013018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR002385"],"award-info":[{"award-number":["KL2TR002385"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002384"],"award-info":[{"award-number":["UL1TR002384"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K24AG053462"],"award-info":[{"award-number":["K24AG053462"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2025,8,28]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Negative self-perceptions of ageing are associated with decreased health-related quality of life (HRQoL) in older adults. We sought to characterise the association of self-perceptions of ageing, both positive and negative, with pain, depression and self-reported disability and frailty status in middle-aged and older adults with SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled adults \u226550 years with validated SLE in a single-centre cross-sectional study. Sociodemographic characteristics and disease features were self-reported. Self-perceptions of ageing were assessed using awareness of age-related change (AARC). We assessed patient-reported outcomes, disability and frailty status using the Patient-Reported Outcomes Measurement Information System 29-Item Profile (PROMIS-29), Valued Life Activities and Fatigue, Resistance, Ambulation, Illness, Loss of Weight Scale. Associations between AARC gains (ie, positive self-perception of ageing) and losses (ie, negative self-perception of ageing) and pain interference, depression, disability and frailty status (frail \u22653\/5 criteria) were assessed using linear or logistic regression and adjusted for age, race, ethnicity, and SLE disease activity and organ damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants (n=80) were mostly female (95.0%) with mean age and SLE duration of 63.2 (SD=8.5) years and 23.1 (SD=14.5) years, respectively. Mean PROMIS-29 T-scores for pain interference and depression were 54.6 (SD=10.1) and 49.8 (SD=8.5), respectively; 29.9% were frail. After covariate adjustment, AARC losses, but not gains were significantly associated with pain interference (\u00df coefficient 0.94, 95% CI 0.33 to 1.54, p&lt;0.01), depression (\u00df coefficient 0.67, 95%\u2009CI 0.04 to 1.30, p=0.04) and frailty (OR 2.09, 95%\u2009CI 1.30 to 3.37, p&lt;0.01). After covariate adjustment, both AARC gains (\u00df coefficient \u22120.07, 95%\u2009CI \u22120.09 to \u20130.02, p&lt;0.01) and losses (\u00df coefficient 0.08, 95%\u2009CI 0.03 to 0.12, p&lt;0.01) were statistically significantly associated with disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Negative self-perception of ageing was independently associated with decreased HRQoL among middle-aged and older adults with SLE. Addressing negative self-perceptions of ageing may improve HRQoL in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/lupus-2025-001576","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T06:15:20Z","timestamp":1759299320000},"page":"e001576","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Perceptions of ageing among middle-aged and older adults with SLE: a single-centre cross-sectional study"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6176-9740","authenticated-orcid":false,"given":"Sarah B","family":"Lieber","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Hospital for Special Surgery, New York City, New York, USA"},{"name":"Department of Medicine, Weill Cornell Medicine, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Shea","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah P","family":"Gottesman","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaya","family":"Smole","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha G","family":"Nagpal","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Chung","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital for Special Surgery, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Navarro-Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital for Special Surgery, New York City, New York, USA"},{"name":"Department of Medicine, Weill Cornell Medicine, New York City, New York, USA"},{"name":"Division of General Internal Medicine, Weill Cornell Medicine, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Carrington","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medicine, New York City, New York, USA"},{"name":"Division of Geriatrics and Palliative Medicine, Weill Cornell Medicine, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A","family":"Mandl","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital for Special Surgery, New York City, New York, USA"},{"name":"Department of Medicine, Weill Cornell Medicine, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"2026010700553465000_12.2.e001576.1","doi-asserted-by":"crossref","unstructured":"Lieber SB , Young SR , Shea Y , et al . 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Loneliness and social isolation among middle-aged and older adults with systemic lupus erythematosus: a single center cross-sectional study. Rheumatology (Oxford) 2025. doi:10.1093\/rheumatology\/keaf342","DOI":"10.1093\/rheumatology\/keaf342"},{"key":"2026010700553465000_12.2.e001576.13","doi-asserted-by":"crossref","unstructured":"Velaithan V , Tan M-M , Yu T-F , et al . The Association of Self-Perception of Aging and Quality of Life in Older Adults: A Systematic Review. Gerontologist 2024;64. doi:10.1093\/geront\/gnad041","DOI":"10.1093\/geront\/gnad041"},{"key":"2026010700553465000_12.2.e001576.14","doi-asserted-by":"crossref","DOI":"10.1186\/s12877-024-05577-y","article-title":"The bidirectional association between self-perceptions of aging and frailty: the mediating role of subjective cognitive decline","volume":"24","author":"Fang","year":"2024","journal-title":"BMC Geriatr"},{"key":"2026010700553465000_12.2.e001576.15","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1080\/07317115.2024.2355539","article-title":"Reimagine Aging: A Process-Based Intervention to Decrease Internalized Ageism","volume":"48","author":"Murphy","year":"2025","journal-title":"Clin Gerontol"}],"container-title":["Lupus Science &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/lupus-2025-001576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:56:17Z","timestamp":1767776177000},"score":1,"resource":{"primary":{"URL":"https:\/\/lupus.bmj.com\/lookup\/doi\/10.1136\/lupus-2025-001576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,9,30]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/lupus-2025-001576"],"URL":"https:\/\/doi.org\/10.1136\/lupus-2025-001576","relation":{},"ISSN":["2053-8790"],"issn-type":[{"value":"2053-8790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}