{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T12:57:07Z","timestamp":1781269027186,"version":"3.54.1"},"reference-count":14,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"unspecified","delay-in-days":162,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Instituto Hip\u00f3lito Unanue, Lima"},{"name":"Pan American League of Associations for Rheumatology","award":["2015 PANLAR Prize"],"award-info":[{"award-number":["2015 PANLAR Prize"]}]},{"name":"Pan American League of Associations for Rheumatology","award":["2018 H. Ralph Schumacher MD \/ JCR \/ PANLAR Prize"],"award-info":[{"award-number":["2018 H. Ralph Schumacher MD \/ JCR \/ PANLAR Prize"]}]},{"name":"EsSalud, Lima, Peru","award":["2015 Kaelin Prize 04-IETSI-ESALUD-2016"],"award-info":[{"award-number":["2015 Kaelin Prize 04-IETSI-ESALUD-2016"]}]},{"DOI":"10.13039\/100020707","name":"Janssen Pharmaceutical","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020707","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2026,6,1]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Frailty has been shown to predict damage accrual in patients with systemic lupus erythematosus (SLE), including those from Latin America. However, the impact of frailty on mortality has been scarcely evaluated, particularly in Latin American populations. The aim of this study was to evaluate frailty as a predictor of mortality in Latin American SLE patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients from a single-centre 2012\u20132025\u2009prevalent cohort were studied. Mortality was defined as the vital status according to the Peruvian Department of Health. Frailty was ascertained using the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) as a continuous variable. Univariable and multivariable Cox regression models were done to estimate its impact on mortality. Multivariable models were adjusted for possible confounders. Sensitivity analyses were performed including data up to March 2020 to avoid the potential influence of the COVID-19 pandemic. Additionally, a Kaplan-Meier curve was calculated by frail status (frail, SLICC-FI &gt;0.21; non-frail, SLICC-FI \u22640.21).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four hundred and ninety-five patients were included, 456 (92.1%) were women and 96 (19.4%) were frail. Their mean (SD) age at diagnosis was 35.0 (14.0) years, their mean disease duration at baseline was 6.7 (6.1) years and their mean follow-up time was 8.5 (4.2) years. Fifty-six (11.3%) patients died during the follow-up. The SLICC-FI predicted mortality even after adjusting for possible confounders (hazard ratio (HR)=1.54 (CI 95% 1.11 to 2.14), p=0.010). This prediction capability remained on the sensitivity analyses (HR 1.85; (95%\u2009CI 1.30 to 2.61), p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Frailty, as ascertained with the SLICC-FI, was a predictor of mortality in a Latin American cohort of SLE patients. Frailty could be considered in the monitoring of SLE patients; possible interventions to modify it should be developed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/lupus-2025-001938","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T12:05:45Z","timestamp":1781265945000},"page":"e001938","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Lupus International Collaborating Clinics Frailty Index predicts mortality in systemic lupus erythematosus patients: data from the Almenara Lupus Cohort"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6778-8213","authenticated-orcid":false,"given":"Benny Harold","family":"Rashuam\u00e1n-Conche","sequence":"first","affiliation":[{"name":"Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio Violeta","family":"Gamboa-C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"},{"name":"Grupo Peruano de Estudio de Enfermedades Autoinmunes Sist\u00e9micas, Universidad Cient\u00edfica del Sur, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-7054","authenticated-orcid":false,"given":"Victor Rom\u00e1n","family":"Pimentel-Quiroz","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"},{"name":"Grupo Peruano de Estudio de Enfermedades Autoinmunes Sist\u00e9micas, Universidad Cient\u00edfica del Sur, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7812-0608","authenticated-orcid":false,"given":"Anubhav","family":"Singh","sequence":"additional","affiliation":[{"name":"Internal Medicine, Baptist Hospitals of Southeast Texas, Beaumont, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3421-2717","authenticated-orcid":false,"given":"Cristina","family":"Re\u00e1tegui-Sokolova","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Elera-Fitzcarrald","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Garcia-Hirsh","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Pastor-Asurza","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"},{"name":"School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoila","family":"Rodr\u00edguez-Bellido","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"},{"name":"School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto Alfredo","family":"Perich-Campos","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"},{"name":"School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela S","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Marnix E. Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA"},{"name":"School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1728-1999","authenticated-orcid":false,"given":"Manuel Francisco","family":"Ugarte-Gil","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"},{"name":"Grupo Peruano de Estudio de Enfermedades Autoinmunes Sist\u00e9micas, Universidad Cient\u00edfica del Sur, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"2026061205052167000_13.1.e001938.1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(24)00191-7"},{"key":"2026061205052167000_13.1.e001938.2","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2021.14"},{"key":"2026061205052167000_13.1.e001938.3","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/art.40859","article-title":"Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus","volume":"71","author":"Legge","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"2026061205052167000_13.1.e001938.4","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1093\/rheumatology\/keab546","article-title":"External validation of the Systemic Lupus International Collaborating Clinics Frailty Index as a predictor of adverse health outcomes in systemic lupus erythematosus","volume":"61","author":"Legge","year":"2022","journal-title":"Rheumatology (Sunnyvale)"},{"key":"2026061205052167000_13.1.e001938.5","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1177\/09612033221126855","article-title":"The SLICC-FI Predicts Damage Accrual in SLE Patients. Data From the Almenara Lupus Cohort","volume":"31","author":"Elera-Fitzcarrald","year":"2022","journal-title":"Lupus"},{"key":"2026061205052167000_13.1.e001938.6","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/acr.25544","article-title":"Systemic Lupus International Collaborating Clinics Frailty Index Predicts Worsening Health\u2010Related Quality of Life, Data From the Almenara Lupus Cohort","volume":"77","author":"Singh","year":"2025","journal-title":"Arthritis Care Res"},{"key":"2026061205052167000_13.1.e001938.7","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2025-001624","article-title":"Systemic Lupus International Collaborating Clinics-Frailty Index predicts hospitalisations in the Almenara Lupus Cohort","volume":"12","author":"Singh","year":"2025","journal-title":"Lupus Sci Med"},{"key":"2026061205052167000_13.1.e001938.8","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"2026061205052167000_13.1.e001938.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"2026061205052167000_13.1.e001938.10","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2021-002111","article-title":"Frailty in rheumatoid arthritis and its relationship with disease activity, hospitalisation and mortality: a longitudinal analysis of the Scottish Early Rheumatoid Arthritis cohort and UK Biobank","volume":"8","author":"Hanlon","year":"2022","journal-title":"RMD Open"},{"key":"2026061205052167000_13.1.e001938.11","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/rheumatology\/kez388","article-title":"Long-term outcomes in elderly patients with ANCA-associated vasculitis","volume":"59","author":"McGovern","year":"2020","journal-title":"Rheumatology (Sunnyvale)"},{"key":"2026061205052167000_13.1.e001938.12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s12016-022-08943-z","article-title":"Inflammaging and Frailty in Immune-Mediated Rheumatic Diseases: How to Address and Score the Issue","volume":"64","author":"Salaffi","year":"2023","journal-title":"Clin Rev Allergy Immunol"},{"key":"2026061205052167000_13.1.e001938.13","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2023-000905","article-title":"Frailty and emergency department utilisation in adults with systemic lupus erythematosus \u226465 years of age: an administrative claims data analysis of Medicaid beneficiaries","volume":"10","author":"Lieber","year":"2023","journal-title":"Lupus Sci Med"},{"key":"2026061205052167000_13.1.e001938.14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/03007995.2026.2637197","article-title":"Influence of frailty syndrome on disease outcomes in systemic lupus erythematosus: a systematic review and narrative synthesis","volume":"42","author":"Serrano-Vertiz","year":"2026","journal-title":"Curr Med Res Opin"}],"container-title":["Lupus Science &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/lupus-2025-001938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T12:05:48Z","timestamp":1781265948000},"score":1,"resource":{"primary":{"URL":"https:\/\/lupus.bmj.com\/lookup\/doi\/10.1136\/lupus-2025-001938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,6,12]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1136\/lupus-2025-001938"],"URL":"https:\/\/doi.org\/10.1136\/lupus-2025-001938","relation":{},"ISSN":["2053-8790"],"issn-type":[{"value":"2053-8790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}