{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:04:00Z","timestamp":1789643040711,"version":"4.0.0"},"reference-count":42,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"unspecified","delay-in-days":78,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2026,7,28]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Fatigue is a common, multifaceted symptom in SLE which is difficult to treat. There has been a lack of broadly accepted SLE-specific assessment tools for fatigue. This study assessed the psychometric properties of the FATIGUE-PRO, a new patient-reported outcome measure, in patients with SLE in real-world clinical outpatient settings (Birmingham, UK, and D\u00fcsseldorf, Germany).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with SLE aged \u226518 years from cross-sectional, observational studies in Birmingham and D\u00fcsseldorf completed the three FATIGUE-PRO domains (physical fatigue, mental and cognitive fatigue and susceptibility to fatigue). Psychometric evaluation was completed using Rasch Measurement Theory and classical test theory methods. Association between the FATIGUE-PRO and other clinical outcome assessments was evaluated using Spearman\u2019s rank order correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 200 patients were recruited from Birmingham and 234 from D\u00fcsseldorf. The FATIGUE-PRO demonstrated consistently adequate measurement properties. Items demonstrated high levels of targeting (82\u201395%)\u2009and the response scale functioned as intended for most items across all domains (82\u2212100% ordered thresholds). Domains were cohesive overall, with minimal item misfit, and demonstrated little local dependency. Principal component analysis of residuals was supportive of unidimensionality of all three domains. All domain scores were reliable and demonstrated high internal consistency reliability (0.90\u22120.97). Moderate-to-high correlations, supportive of construct validity, were observed between the FATIGUE-PRO scores and other patient-reported outcomes, including Lupus Quality of Life. Low correlations were seen with outcome measures such as Brief Index of Lupus Damage and clinician-reported SLE Disease Activity Index-2000.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The FATIGUE-PRO was demonstrated to be fit-for-purpose in real-world clinical outpatient settings, with strong measurement properties, supporting its use in the assessment of fatigue in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/lupus-2026-002071","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:40:19Z","timestamp":1789641619000},"page":"e002071","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Measurement properties of the FATIGUE-PRO in patients with SLE in real-world settings"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct02804763","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04294667","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-6443","authenticated-orcid":false,"given":"Caroline","family":"Gordon","sequence":"first","affiliation":[{"name":"Department of Inflammation and Ageing, College of Medicine and Health, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schneider","sequence":"additional","affiliation":[{"name":"Clinic of Rheumatology and Hiller Research Unit, Heinrich Heine University, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal","family":"Chehab","sequence":"additional","affiliation":[{"name":"Clinic of Rheumatology and Hiller Research Unit, Heinrich Heine University, D\u00fcsseldorf, Germany"},{"name":"Department of Rheumatology and Clinical Immunology, KEM Kliniken Essen-Mitte, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Cano","sequence":"additional","affiliation":[{"name":"Modus Outcomes, a THREAD Company, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Regnault","sequence":"additional","affiliation":[{"name":"Modus Outcomes, a THREAD Company, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stach","sequence":"additional","affiliation":[{"name":"UCB, Monheim am Rhein, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"de la Loge","sequence":"additional","affiliation":[{"name":"UCB, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2524-5592","authenticated-orcid":false,"given":"Sophie","family":"Cleanthous","sequence":"additional","affiliation":[{"name":"Modus Outcomes, a THREAD Company, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0690-5359","authenticated-orcid":false,"given":"Thomas","family":"Morel","sequence":"additional","affiliation":[{"name":"UCB, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"2026091703401002000_13.2.e002071.1","unstructured":"Lupus and Allied Diseases Association . 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