{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:28:28Z","timestamp":1792787308505,"version":"4.5.0"},"reference-count":40,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"unspecified","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Taiwan National Science and Technology Council","award":["NSTC 112-2314-B-006 -068 -MY3"],"award-info":[{"award-number":["NSTC 112-2314-B-006 -068 -MY3"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2629-H-006-002-SS2"],"award-info":[{"award-number":["NSTC 113-2629-H-006-002-SS2"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX114-11410PI"],"award-info":[{"award-number":["NHRI-EX114-11410PI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"name":"US National Institutes of Health","award":["R03CA273608"],"award-info":[{"award-number":["R03CA273608"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Alex\u2019s Lemonade Stand Foundation","award":["17-01882"],"award-info":[{"award-number":["17-01882"]}],"id":[{"id":"https:\/\/ror.org\/038ja4880","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Lupus Sci Med"],"accepted":{"date-parts":[[2026,7,31]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Prior studies suggested that maternal systemic autoimmune rheumatic diseases (SARDs) may increase the risk of mental disorders (MDs) in offspring. However, evidence is limited by heterogeneous definitions of autoimmune rheumatic diseases, focusing on specific MDs and scarce data from Asian populations. We aimed to investigate the association between maternal SARDs and the risk of childhood MDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our study included 1\u2009949\u2009968 maternal-child dyads identified in the Taiwan Maternal and Child Health Database between 2004 and 2015. Maternal SARD diagnoses were identified based on approved catastrophic illness certificates, while childhood MDs were identified by documentation of a relevant diagnostic code in the nationwide health insurance claims data. Cox proportional hazard models were used to examine the association between maternal SARDs and childhood MDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After a mean follow-up of 11.7 years, there were 774 (19.8%) and 306\u2009907 (15.8%) live births born to mothers with and without SARDs respectively, which developed childhood MDs. Maternal SARDs were associated with an increased risk of childhood MDs (HR, 1.30; 95% CI 1.19 to 1.41). Elevated risks of childhood MDs were observed among offspring of mothers with systemic lupus erythematosus (HR=1.26, 95% CI 1.13 to 1.41), primary Sjogren\u2019s syndrome (HR=1.59, 95% CI 1.29 to 1.97), idiopathic inflammatory myositis (HR=1.73, 95% CI 1.06 to 2.83) and systemic sclerosis (HR=1.94, 95% CI 1.15 to 3.28), compared with mothers without SARDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this nationwide, population-based study from an Asian population, maternal SARDs were associated with higher risks of childhood MDs. Our findings suggest early monitoring of MDs among offspring of mothers with SARDs as part of clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/lupus-2026-002129","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:40:16Z","timestamp":1786711216000},"page":"e002129","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal systemic autoimmune rheumatic diseases and childhood mental disorders: a nationwide cohort study"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2072-7277","authenticated-orcid":false,"given":"Ya-Chun","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyan","family":"Liew","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yu","family":"Weng","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E","family":"Heck","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA"},{"name":"School of Health Sciences, University of North Texas, Denton, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan"},{"name":"Universit\u00e9 Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, 94805, Villejuif, 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