{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:02:09Z","timestamp":1777374129734,"version":"3.51.4"},"reference-count":30,"publisher":"BMJ","issue":"4","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Med Ethics"],"accepted":{"date-parts":[[2018,12,21]]},"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Non-invasive prenatal testing (NIPT) is at the forefront of prenatal screening. Current uses for NIPT include fetal sex determination and screening for chromosomal disorders such as trisomy 21 (Down syndrome). However, NIPT may be expanded to many different future applications. There are a potential host of ethical concerns around the expanding use of NIPT, as examined by the recent Nuffield Council report on the topic. It is important to examine what NIPT might be used for before these possibilities become consumer reality. There is limited research exploring views of women on possible future uses of NIPT, particularly those of women who have undergone NIPT. In this study, we examined the views of women who undertook NIPT previously on the acceptability of and interest levels in using NIPT for a number of current and possible future applications. These included several medical conditions encompassing psychiatric, neurodevelopmental and adult-onset conditions as well as non-medical traits such as intelligence. One thousand women were invited to participate and 235 eligible surveys were received. Women generally reported an interest in using NIPT for medical conditions that severely impacted quality of life and with an onset earlier in life and stressed the importance of the accuracy of the test. Concerns were raised about the use of NIPT for non-medical traits. Respondents indicated that termination of pregnancy was not their only reason for testing, particularly in the case of sex. These results can further inform the ethical debate around the increasing integration of NIPT into healthcare systems.<\/jats:p>","DOI":"10.1136\/medethics-2018-105167","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T11:33:28Z","timestamp":1548416008000},"page":"231-238","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["\u2018Is it better not to know certain things?\u2019: views of women who have undergone non-invasive prenatal testing on its possible future applications"],"prefix":"10.1136","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2142-9696","authenticated-orcid":false,"given":"Hilary","family":"Bowman-Smart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Savulescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara","family":"Mand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Gyngell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D","family":"Pertile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin B","family":"Delatycki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"2024111106500589000_45.4.231.1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.55"},{"key":"2024111106500589000_45.4.231.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705345"},{"key":"2024111106500589000_45.4.231.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615800113"},{"key":"2024111106500589000_45.4.231.4","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010002","article-title":"Accuracy of non-invasive prenatal testing using cell-free DNA for detection of Down, Edwards and Patau syndromes: a systematic review and meta-analysis","volume":"6","author":"Taylor-Phillips","year":"2016","journal-title":"BMJ Open"},{"key":"2024111106500589000_45.4.231.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2017.02.007"},{"key":"2024111106500589000_45.4.231.6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14636"},{"key":"2024111106500589000_45.4.231.7","unstructured":"Nuffield Council on Bioethics. Non-invasive prenatal testing: ethical issues, 2017."},{"key":"2024111106500589000_45.4.231.8","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.57"},{"key":"2024111106500589000_45.4.231.9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153147","article-title":"Women\u2019s experiences and preferences for service delivery of non-invasive prenatal testing for aneuploidy in a public health setting: a mixed methods study","volume":"11","author":"Lewis","year":"2016","journal-title":"PLoS One"},{"key":"2024111106500589000_45.4.231.10","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jemep.2016.07.007","article-title":"Experiences of Mandarin-speaking and English-speaking women of undergoing non-invasive prenatal genetic screening","volume":"2","author":"Li","year":"2016","journal-title":"Ethics, Medicine and Public Health"},{"key":"2024111106500589000_45.4.231.11","doi-asserted-by":"publisher","DOI":"10.1177\/1049732315589745"},{"key":"2024111106500589000_45.4.231.12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081794","article-title":"Motivations for undertaking DNA sequencing-based non-invasive prenatal testing for fetal aneuploidy: a qualitative study with early adopter patients in Hong Kong","volume":"8","author":"Yi","year":"2013","journal-title":"PLoS One"},{"key":"2024111106500589000_45.4.231.13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/uog.13394","article-title":"Counseling for non-invasive prenatal testing (NIPT): what pregnant women may want to know","volume":"44","author":"Oepkes","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2024111106500589000_45.4.231.14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/ajmg.a.37460","article-title":"Non-invasive prenatal screening for trisomy 21: Consumers\" perspectives","volume":"170A","author":"Higuchi","year":"2016","journal-title":"Am J Med Genet A"},{"key":"2024111106500589000_45.4.231.15","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2205"},{"key":"2024111106500589000_45.4.231.16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/birt.12113","article-title":"What women want: lead considerations for current and future applications of noninvasive prenatal testing in prenatal care","volume":"41","author":"Farrell","year":"2014","journal-title":"Birth"},{"key":"2024111106500589000_45.4.231.17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/pd.4579","article-title":"NIPT-based screening for Down syndrome and beyond: what do pregnant women think?","volume":"35","author":"van Schendel","year":"2015","journal-title":"Prenat Diagn"},{"key":"2024111106500589000_45.4.231.18","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/ejhg.2014.32","article-title":"Attitudes of pregnant women and male partners towards non-invasive prenatal testing and widening the scope of prenatal screening","volume":"22","author":"van Schendel","year":"2014","journal-title":"Eur J Hum Genet"},{"key":"2024111106500589000_45.4.231.19","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3390\/rel3030710","article-title":"The Centrality of Religiosity Scale (CRS)","volume":"3","author":"Huber","year":"2012","journal-title":"Religions"},{"key":"2024111106500589000_45.4.231.20","doi-asserted-by":"publisher","DOI":"10.1037\/rev0000093"},{"key":"2024111106500589000_45.4.231.21","doi-asserted-by":"crossref","unstructured":"Williamson K , Given LM , Scifleet P . 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