{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T12:43:08Z","timestamp":1775047388469,"version":"3.50.1"},"reference-count":49,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1700917N"],"award-info":[{"award-number":["1700917N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Med Ethics"],"accepted":{"date-parts":[[2019,9,1]]},"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Detection of genetic aberrations in prenatal samples, obtained through amniocentesis or chorion villus biopsy, is increasingly performed using chromosomal microarray (CMA), a technique that can uncover both aneuploidies and copy number variants throughout the genome. Despite the obvious benefits of CMA, the decision on implementing the technology is complicated by ethical issues concerning variant interpretation and reporting. In Belgium, uniform guidelines were composed and a shared database for prenatal CMA findings was established. This Belgian approach sparks discussion: it is evidence-based, prevents inconsistencies and avoids parental anxiety, but can be considered paternalistic. Here, we reflect on the cultural and moral bases of the Belgian reporting system of prenatally detected variants.<\/jats:p>","DOI":"10.1136\/medethics-2018-105186","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T17:25:19Z","timestamp":1568654719000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Chromosomal microarray analysis in prenatal diagnosis: ethical considerations of the Belgian approach"],"prefix":"10.1136","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-7464","authenticated-orcid":false,"given":"Joke","family":"Muys","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Universitair Ziekenhuis Antwerpen, Edegem, Belgium"},{"name":"Center for Medical Genetics, Universiteit Antwerpen, Edegem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Blaumeiser","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, Universiteit Antwerpen, Edegem, Belgium"},{"name":"Department of Medical Genetics, Universitair Ziekenhuis Antwerpen, Edegem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrien","family":"Janssens","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, Universiteit Antwerpen, Edegem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Loobuyck","sequence":"additional","affiliation":[{"name":"Center for Ethics, Universiteit Antwerpen, Edegem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Jacquemyn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Universitair Ziekenhuis Antwerpen, Edegem, Belgium"},{"name":"Global Health Institute, Universiteit Antwerpen, Edegem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"2025092414503904000_46.2.104.1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2933"},{"issue":"6","key":"2025092414503904000_46.2.104.2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/gim.2013.168","article-title":"A prospective study of the clinical utility of prenatal chromosomal microarray analysis in fetuses with ultrasound abnormalities and an exploration of a framework for reporting unclassified variants and risk factors","volume":"16","author":"Brady","year":"2014","journal-title":"Genet Med"},{"key":"2025092414503904000_46.2.104.3","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12575"},{"key":"2025092414503904000_46.2.104.4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12464"},{"key":"2025092414503904000_46.2.104.5","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7754"},{"key":"2025092414503904000_46.2.104.6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bpobgyn.2017.01.003","article-title":"Microarrays in prenatal diagnosis","volume":"42","author":"Oneda","year":"2017","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2025092414503904000_46.2.104.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203382"},{"issue":"5","key":"2025092414503904000_46.2.104.8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/ejhg.2015.193","article-title":"Prenatal SNP array testing in 1000 fetuses with ultrasound anomalies: causative, unexpected and susceptibility CNVs","volume":"24","author":"Srebniak","year":"2016","journal-title":"Eur J Hum Genet"},{"key":"2025092414503904000_46.2.104.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.04.006"},{"issue":"4","key":"2025092414503904000_46.2.104.10","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2016.07.016","article-title":"The use of chromosomal microarray for prenatal diagnosis","volume":"215","author":"Dugoff","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"2-3","key":"2025092414503904000_46.2.104.11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000442904","article-title":"A French approach to test fetuses with ultrasound abnormalities using a customized microarray as First-Tier genetic test","volume":"147","author":"Malan","year":"2016","journal-title":"Cytogenet Genome Res"},{"issue":"5","key":"2025092414503904000_46.2.104.12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/uog.19035","article-title":"A new comprehensive paradigm for prenatal diagnosis: seeing the forest through the trees","volume":"52","author":"Borrell","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2025092414503904000_46.2.104.13","unstructured":"Stockholm . 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