{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T19:40:28Z","timestamp":1758742828892,"version":"3.44.0"},"reference-count":64,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Med Humanities"],"accepted":{"date-parts":[[2018,1,22]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>The medieval English romance <jats:italic>The King of Tars<\/jats:italic> gives an account of a birth of a lump of flesh. This has been considered as fantastic and monstrous in past literature, the horrific union of a Christian and Saracen. However, while the text certainly speaks to miscegenation, we propose that this lump of flesh is actually a hydatidiform mole. We trace the hydatidiform mole from antiquity, surrounding it with contextual medieval examples, from theology, history and medicine, that also describe abnormal births as \u2018lumps of flesh\u2019. By discussing medieval ideas of monsters as a warning sign, we interpret the lump of flesh in terms of abnormal births, seed transmission, parental contribution and sin. Ideas of warning, blame and intervention present themselves as a response to moles both in medieval texts as well as in modern reactions to hydatidiform moles. We explore the epigenetics of hydatidiform moles and relate them to the medieval text. In <jats:italic>The King of Tars<\/jats:italic>, the fault for the lump of flesh could reside with either parent; we find that this is also the case in the genetic formation of the hydatidiform mole; we also argue that the epigenetics supports medieval theories of seed transmission.<\/jats:p>","DOI":"10.1136\/medhum-2017-011387","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T12:17:56Z","timestamp":1533644276000},"page":"2-9","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Genetics, molar pregnancies and medieval ideas of monstrous births: the lump of flesh in <i>The King of Tars<\/i>"],"prefix":"10.1136","volume":"45","author":[{"given":"Natalie","family":"Goodison","sequence":"first","affiliation":[{"name":"Department of English Studies, Durham University, Durham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah J G","family":"Mackay","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Genomics Medicine, Faculty of Medicine, University of Southampton, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I Karen","family":"Temple","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Genomics Medicine, Faculty of Medicine, University of Southampton, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"2025092412220361000_45.1.2.1","unstructured":"Barber R, tr . Bestiary: being an English version of the Bodleian Library, Oxford, MS Bodley 764. Woodbridge: Boydell Press, 1999."},{"key":"2025092412220361000_45.1.2.2","first-page":"661","volume-title":"Concerning the city of god against the pagans","volume":"XVI.8","author":"Augustine","year":"2003"},{"key":"2025092412220361000_45.1.2.3","unstructured":"Throop P tr . Hildegard Von Bingen\u2019s physica: the complete English translation of her classic work on health and healing. Rochester, VT: Healing Arts Press, 1998:59, 87."},{"key":"2025092412220361000_45.1.2.4","unstructured":"Chandler JH , ed. The King of Tars. Kalamazoo, MI: Medieval Institute Publications, 2015:261. Future references are to this edition to line number."},{"key":"2025092412220361000_45.1.2.5","doi-asserted-by":"crossref","unstructured":"Purdie R . \u00a0Anglicising romance. Cambridge: D. S. Brewer, 2008:207\u20139.","DOI":"10.1515\/9781846156090"},{"key":"2025092412220361000_45.1.2.6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2307\/2910989","article-title":"Trivet\u2019s Constance and the\u00a0King of Tars","volume":"55","author":"Hornstein","year":"1940","journal-title":"Modern Language Notes"},{"key":"2025092412220361000_45.1.2.7","first-page":"219","article-title":"Marking religion on the body: Saracens, categorization, and The King of Tars","volume":"104","author":"Calkin","year":"2005","journal-title":"Journal of English and Germanic Philology"},{"key":"2025092412220361000_45.1.2.8","doi-asserted-by":"crossref","unstructured":"Gilbert J . Putting the pulp into fiction: the lump-child and its parents in The King of Tars. In: McDonald N , ed. Pulp fictions of medieval England: essays in popular romance. Manchester: Manchester University Press, 2004:102\u201323.","DOI":"10.7228\/manchester\/9780719063183.003.0006"},{"key":"2025092412220361000_45.1.2.9","unstructured":"Calkin SB . Saracens and the making of English identity: the Auchinleck manuscript. London: Routledge, 2005:113."},{"key":"2025092412220361000_45.1.2.10","doi-asserted-by":"crossref","first-page":"432","DOI":"10.2307\/3717084","article-title":"New analogues to The King of Tars","volume":"36","author":"Hornstein","year":"1941","journal-title":"Modern Language Review"},{"key":"2025092412220361000_45.1.2.11","unstructured":"Heng G . Empire of magic: medieval romance and the politics of cultural fantasy. New York: Columbia University Press, 2003:228."},{"key":"2025092412220361000_45.1.2.12","doi-asserted-by":"crossref","unstructured":"Saunders C . Magic and the supernatural in medieval English romance. Cambridge: D S Brewer, 2010:209.","DOI":"10.1017\/9781846158056"},{"key":"2025092412220361000_45.1.2.13","unstructured":"Frye N . An anatomy of criticism. Princeton: Princeton University Press, 1957:186."},{"key":"2025092412220361000_45.1.2.14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.5406\/jenglgermphil.115.4.0442","article-title":"Anima carnis in sanguine est: blood, life, and The King of Tars","volume":"115","author":"Star","year":"2016","journal-title":"Journal of English and Germanic Philology"},{"key":"2025092412220361000_45.1.2.15","doi-asserted-by":"crossref","unstructured":"Walter KL . The form of the formless: medieval taxonomies of skin, flesh, and the human. In: Walter KL , Reading skin in medieval literature and culture. Basingstoke: Palgrave Macmillan, 2013:119\u201339\u00a0(130).","DOI":"10.1057\/9781137084644_7"},{"key":"2025092412220361000_45.1.2.16","doi-asserted-by":"crossref","unstructured":"Florschuetz A . Marking maternity in Middle English romance: mothers, identity, and contamination. Basingstoke: Palgrave Macmillan, 2014:103\u20134.","DOI":"10.1057\/9781137343499"},{"key":"2025092412220361000_45.1.2.17","unstructured":"\u2018round(e)\u2019, n.1. Middle English Dictionary. Medieval Institute Publications. https:\/\/quod.lib.umich.edu\/cgi\/m\/mec\/med-idx?type=id&id=MED37977 (accessed 26 Sep 2017)."},{"key":"2025092412220361000_45.1.2.18","unstructured":"\u2018flesh\u2019, n.1. Middle English Dictionary. Medieval Institute Publications. https:\/\/quod.lib.umich.edu\/cgi\/m\/mec\/med-idx?type=id&id=MED16282. (accessed 26 Sep 2017)."},{"key":"2025092412220361000_45.1.2.19","first-page":"276","volume-title":"On the properties of things: John Trevisa\u2019s translation of Bartholomaeus Anglicus De proprietatibus rerum: a critical text","volume":"I","year":"1975\u20131988"},{"key":"2025092412220361000_45.1.2.20","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/268633a0","article-title":"Androgenetic origin of hydatidiform mole","volume":"268","author":"Kajii","year":"1997","journal-title":"Nature"},{"key":"2025092412220361000_45.1.2.21","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20993"},{"key":"2025092412220361000_45.1.2.22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.281.6250.1233"},{"key":"2025092412220361000_45.1.2.23","first-page":"103","article-title":"The epidemiology of gestational trophoblastic disease","volume":"143","author":"Di Cintio","year":"1997","journal-title":"Gen Diagn Pathol"},{"key":"2025092412220361000_45.1.2.24","unstructured":"\u2018mole\u2019, n.4. OED Online. Oxford University Press. http:\/\/www.oed.com.ezphost.dur.ac.uk\/view\/Entry\/120839?rskey=Dlq8ui&result=4 (accessed 26 Sep 2017)."},{"key":"2025092412220361000_45.1.2.25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4473.460"},{"key":"2025092412220361000_45.1.2.26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4778.283"},{"key":"2025092412220361000_45.1.2.27","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.1981.1814"},{"key":"2025092412220361000_45.1.2.28","first-page":"1198","article-title":"A case of hydatidiform mole","volume":"2","author":"Roberts","year":"1924","journal-title":"Br Med J"},{"key":"2025092412220361000_45.1.2.29","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJM195903122601107","article-title":"New England\u2019s first recorded hydatidiform mole","volume":"260","author":"Richardson","year":"1959","journal-title":"N Engl J Med Overseas Ed"},{"key":"2025092412220361000_45.1.2.30","unstructured":"Aristotle. 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Beitr\u00e4ge zur Geschichte der Philosophie des Mittelalters\u00a015\u201316. Vol 15. M\u00fcnster, 1916\u20131920. Liber X, tract 1., capt. 4:742\u20134."},{"key":"2025092412220361000_45.1.2.36","unstructured":"Lemay HR , tr. and ed. Women\u2019s secrets: a translation of pseudo-Albertus Magnus\u2019 De Secretis Mulierum with commentaries. Albany, NY: State University of New York Press, 1992:67\u20138."},{"key":"2025092412220361000_45.1.2.37","doi-asserted-by":"crossref","unstructured":"Green MH . Making women\u2019s medicine masculine: the rise of male authority in pre-modern gynaecology. Oxford: Oxford University Press, 2008:314.","DOI":"10.1093\/oso\/9780199211494.001.0001"},{"key":"2025092412220361000_45.1.2.38","unstructured":"Hansen B , ed. and tr. Nicole Oresme and the marvels of nature: a study of his De causis mirabilium. Toronto: Pontificate Institute of Mediaeval Studies, 1985:228\u201331, 236\u20137."},{"key":"2025092412220361000_45.1.2.39","unstructured":"de Chauliac G . The Cyrurgie of Guy de Chauliac. Ogden MS , ed. London: Early English Text Society, 1971:531."},{"key":"2025092412220361000_45.1.2.40","unstructured":"\u2018gobat\u2019, n.2. Middle English Dictionary. Medieval Institute Publications. https:\/\/quod.lib.umich.edu\/cgi\/m\/mec\/med-idx?type=id&id=MED18938 (accessed 26 Sep 2017)."},{"key":"2025092412220361000_45.1.2.41","unstructured":"Stevenson J , ed. Chronicon de Lanercost. Edinburgh: Bannatyne and Maitland Club, 1839:104."},{"key":"2025092412220361000_45.1.2.42","unstructured":"Maxwell H , tr. The Chronicle of Lanercost: 1272\u20131346. 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Genetic and Rare Diseases Information Center from the US Department of Health and Human Services. https:\/\/rarediseases.info.nih.gov\/diseases\/2865\/hypertrichosis-lanuginosa-congenita (accessed 26 Sep 2017)."},{"key":"2025092412220361000_45.1.2.47","unstructured":"Giant congenital nevus. Genetic and Rare Diseases Information Center from the US Department of Health and Human Services. https:\/\/rarediseases.info.nih.gov\/diseases\/2469\/giant-congenital-nevus (accessed 26 Sep 2017)."},{"key":"2025092412220361000_45.1.2.48","unstructured":"McKusick M , Kniffin CL . Holoprosencephaly 1; HPE1. Online Mendelian Inheritance in Man. Baltimore: Johns Hopkins University. https:\/\/www.omim.org\/entry\/ (accessed 19 Dec 2017)."},{"key":"2025092412220361000_45.1.2.49","unstructured":"McTurk R . Studies in Ragnars Saga Lo\u00f0br\u00f3kar and its major Scandinavian analogues. Oxford: Society for the Study of Medieval Languages and Literature, 1991:40\u20131."},{"key":"2025092412220361000_45.1.2.50","unstructured":"Loomis LH . Mediaeval romance in England. New York: Burt Franklin rpnt, 1969:45."},{"key":"2025092412220361000_45.1.2.51","doi-asserted-by":"crossref","unstructured":"Hanna R . London literature 1300\u20131380. Cambridge: Cambridge University Press, 2005.","DOI":"10.1017\/CBO9780511483318"},{"key":"2025092412220361000_45.1.2.52","doi-asserted-by":"crossref","unstructured":"Gilbert J . Unnatural mothers and monstrous children in The King of Tars and Sir Gowther. In: Wogan-Browne J , Voaden R , Diamond A . et al, eds. Medieval women: texts and contexts in late medieval Britain: Essays for Felicity Riddy : Turnhout: Brepols, 2000:329\u201344.","DOI":"10.1484\/M.MWTC-EB.3.3650"},{"key":"2025092412220361000_45.1.2.53","unstructured":"Friedman JB . The monstrous races in medieval art and thought. Syracuse: Syracuse University Press, 2000:111."},{"key":"2025092412220361000_45.1.2.54","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1017\/CBO9780511482113","volume-title":"The etymologies of Isidore of Seville","volume":"XI.iii.4","author":"Barney","year":"2006"},{"key":"2025092412220361000_45.1.2.55","unstructured":"Gerald of Wales. The journey through Wales and the description of Wales. Thorpe L , tr. London: Penguin Books, 1978:191."},{"key":"2025092412220361000_45.1.2.56","first-page":"372","volume-title":"Parzival","volume":"40","author":"von Eschenbach","year":"1980"},{"key":"2025092412220361000_45.1.2.57","doi-asserted-by":"crossref","unstructured":"Brundage JA . Law, sex, and Christian society in\u00a0medieval Europe . Chicago: University of Chicago Press, 1987:195, 207, 238, 518.","DOI":"10.7208\/chicago\/9780226077895.001.0001"},{"key":"2025092412220361000_45.1.2.58","unstructured":"Cadden J . Meanings of sex difference in the middle ages: medicine, science, and culture. Cambridge: Cambridge University Press, 1993:13\u201339, 116\u201330."},{"key":"2025092412220361000_45.1.2.59","doi-asserted-by":"crossref","unstructured":"Green M , ed. and tr. The Trotula: An English translation of the medieval compendium of women\u2019s medicine. Philadelphia: University of Pennsylvania Press, 2002:85.","DOI":"10.9783\/9780812202083"},{"key":"2025092412220361000_45.1.2.60","unstructured":"Perryman J , ed. The King of Tars: ed. from the Auchinleck MS, Advocates 19.2.1. Heidelberg: Winter, 1980:56."},{"key":"2025092412220361000_45.1.2.61","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp461"},{"key":"2025092412220361000_45.1.2.62","doi-asserted-by":"crossref","unstructured":"Par\u00e9 A . On monsters and marvels, Pallister JL , tr. 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