{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:16:04Z","timestamp":1770822964289,"version":"3.50.1"},"reference-count":24,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Mol Pathol"],"published-print":{"date-parts":[[1995,4]]},"DOI":"10.1136\/mp.48.2.m74","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:45:53Z","timestamp":1181349953000},"page":"M74-M78","source":"Crossref","is-referenced-by-count":61,"title":["Loss of heterozygosity in lobular carcinoma in situ of the breast"],"prefix":"10.1136","volume":"48","author":[{"given":"S R","family":"Lakhani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Sloane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R","family":"Stratton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/1097-0142(196711)20:11<1867::AID-CNCR2820201111>3.0.CO;2-#","article-title":"Bilaterality of cancer of the breast. Biopsy of the opposite breast","volume":"20","author":"Urban, J.A.","year":"1967","unstructured":"Urban JA. Bilaterality of cancer of the breast. Biopsy of the opposite breast. Cancer 1967;20: 1867-70.","journal-title":"Cancer"},{"key":"ref_2","first-page":"257","article-title":"Lobular carcinoma in situ of the breast: clinical, pathologic and mammographic features","volume":"157","author":"Beute, B.J.; Kalisher, L.; Hutter, R.V.P.","year":"1991","unstructured":"Beute BJ, Kalisher L, Hutter RVP. Lobular carcinoma in situ of the breast: clinical, pathologic and mammographic features. Am _J Radiol 1991;157:257-65.","journal-title":"Am _J Radiol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1177\/030089169207800405","article-title":"Risk of infiltrating breast cancer subsequent to lobular carcinoma in situ","volume":"78","author":"Ciatto, S.; Catalloti, L.; Cardona, G.; Bianchi, S.","year":"1992","unstructured":"Ciatto S, Catalloti L, Cardona G, Bianchi S. Risk of infiltrating breast cancer subsequent to lobular carcinoma in situ. Tumori 1992;78:244-6.","journal-title":"Tumori"},{"key":"ref_4","first-page":"285","article-title":"Lobular carcinoma in situ of the breast","volume":"164","author":"Frykberg, E.R.; Santiago, F.; Betsill, W.L.; O'Brien, P.H.","year":"1987","unstructured":"Frykberg ER, Santiago F, Betsill WL, O'Brien PH. Lobular carcinoma in situ of the breast. Surg Gynaecol Obstet 1987; 164:285-301.","journal-title":"Surg Gynaecol Obstet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/00000478-199301000-00002","article-title":"Lobular carcinoma in situ of the female breast","volume":"17","author":"Otteson, G.L.; Graverson, H.P.; Blichert-Toft, M.; Zedeler, K.; Andersen, J.A.","year":"1993","unstructured":"Otteson GL, Graverson HP, Blichert-Toft M, Zedeler K, Andersen JA. Lobular carcinoma in situ of the female breast. Am J Surg Pathol 1993;17:14-21.","journal-title":"Am J Surg Pathol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/1097-0142(19900915)66:14+<1326::AID-CNCR2820661405>3.0.CO;2-P","article-title":"Anatomic markers of human premalignancy and risk of breast cancer","volume":"66","author":"Page, D.L.; Dupont, W.D.","year":"1990","unstructured":"Page DL, Dupont WD. Anatomic markers of human premalignancy and risk of breast cancer. Cancer 1990;66: 1326-35.","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/0046-8177(91)90105-X","article-title":"Lobular neoplasia of the breast: higher risk of subsequent invasive cancer predicted by more extensive disease","volume":"22","author":"Page, D.L.; Kidd, T.E.; Dupont, W.D.; Simpson, J.F.; Rogers, L.W.","year":"1991","unstructured":"Page DL, Kidd TE, Dupont WD, Simpson JF, Rogers LW. Lobular neoplasia of the breast: higher risk of subsequent invasive cancer predicted by more extensive disease. Human Pathol 1991;22:1232-9.","journal-title":"Human Pathol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/1097-0142(19820215)49:4<751::AID-CNCR2820490426>3.0.CO;2-Y","article-title":"Intraductal carcinoma of the breast: follow-up after biopsy only","volume":"49","author":"Page, D.L.; Dupont, W.D.; Rogers, L.W.; Landenberger, M.","year":"1982","unstructured":"Page DL, Dupont WD, Rogers LW, Landenberger M. Intraductal carcinoma of the breast: follow-up after biopsy only. Cancer 1982;49:751-8.","journal-title":"Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/1097-0142(19840201)53:3+<798::AID-CNCR2820531331>3.0.CO;2-P","article-title":"The management of patients with lobular carcinoma in situ of the breast","volume":"53","author":"Hutter, R.V.P.","year":"1984","unstructured":"Hutter RVP. The management of patients with lobular carcinoma in situ of the breast. Cancer 1984;53:798-802.","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0344-0338(80)80242-1","article-title":"Lobular neoplasia (lobular carcinoma in situ) of the breast - a histological entity of controversial clinical significance","volume":"166","author":"Lattes, R.","year":"1980","unstructured":"Lattes R. Lobular neoplasia (lobular carcinoma in situ) of the breast - a histological entity of controversial clinical significance. Pathol Res Pract 1980;166:415-29.","journal-title":"Pathol Res Pract"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/jcp.44.9.710","article-title":"Pathology reporting in breast cancer screening","volume":"44","author":"of Pathologists Working Group, Royal College","year":"1991","unstructured":"Royal College of Pathologists Working Group. Pathology reporting in breast cancer screening. JT Clin Pathol 1991; 44:710-25.","journal-title":"JT Clin Pathol"},{"key":"ref_12","first-page":"4640","article-title":"Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci","volume":"18","author":"Weber, J.L.; Kwitek, A.E.; May, P.E.; Wallace, M.R.; Collins, F.S.; Ledbetter, D.H.","year":"1990","unstructured":"Weber JL, Kwitek AE, May PE, Wallace MR, Collins FS, Ledbetter DH. Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci [abstract]. Nucl Acid Res 1990;18:4640.","journal-title":"Nucl Acid Res"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/359794a0","article-title":"A second generation linkage map of the human genome","volume":"359","author":"Weissenbach, J.; Gyapay, G.; Dib, C.; Vignal, A.; Morissette, S.; Millasseau, P.","year":"1992","unstructured":"Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette S, Millasseau P, et al. A second generation linkage map of the human genome. Nature 1992;359:794-7.","journal-title":"Nature"},{"key":"ref_14","article-title":"Loss of heterozygosity in ductal carcinoma in situ of the breast","author":"Stratton, M.R.; Collins, N.; Lakhani, SR, Sloane; J.P.","year":"1995","unstructured":"Stratton MR, Collins N, Lakhani SR, Sloane JP. Loss of heterozygosity in ductal carcinoma in situ of the breast. J Pathol 1995; in press.","journal-title":"J Pathol"},{"key":"ref_15","article-title":"Atypical ductal hyperplasia of the breast: a clonal proliferation exhibiting loss ofheterozygosity on chromosomes 16q and 17p","author":"Lakhani, SR, Collins; N, Stratton; MR, Sloane; J.P.","year":"1995","unstructured":"Lakhani SR, Collins N, Stratton MR, Sloane JP. Atypical ductal hyperplasia of the breast: a clonal proliferation exhibiting loss ofheterozygosity on chromosomes 16q and 17p. J Clin Pathol 1995; in press.","journal-title":"J Clin Pathol"},{"key":"ref_16","first-page":"1705","article-title":"Allotype of human breast carcinoma: a second major site for loss of heterozygosity is on chromosome 6q","volume":"6","author":"Devilee, P.; Van Villet, M.; Van Sloun, P.; Kuipers, N.; Hermans, J.; Pearson, P.L.","year":"1991","unstructured":"Devilee P, Van Villet M, Van Sloun P, Kuipers N, Hermans J, Pearson PL, et al. Allotype of human breast carcinoma: a second major site for loss of heterozygosity is on chromosome 6q. Oncogene 1991;6:1705-11.","journal-title":"Oncogene"},{"key":"ref_17","first-page":"7184","article-title":"Allotype of breast cancer: cumulative allele losses promote tumour progression in primary breast cancer","volume":"50","author":"Sato, T.; Tanigami, A.; Yamakawa, K.; Akiyama, F.; Kasumi, F.; Sakamoto, G.","year":"1990","unstructured":"Sato T, Tanigami A, Yamakawa K, Akiyama F, Kasumi F, Sakamoto G, et al. Allotype of breast cancer: cumulative allele losses promote tumour progression in primary breast cancer. Cancer Res 1990;50:7184-9.","journal-title":"Cancer Res"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF01606541","article-title":"Immunohistochemical profile of invasive breast lobular carcinoma of the breast: predominantly vimentin and p53 protein negative, cathepsin D and oestrogen receptor positive","volume":"423","author":"Domagala, W.; Markiewski, M.; Kubiak, R.; Bartowiak, J.; Osborn, M.","year":"1993","unstructured":"Domagala W, Markiewski M, Kubiak R, Bartowiak J, Osborn M. Immunohistochemical profile of invasive breast lobular carcinoma of the breast: predominantly vimentin and p53 protein negative, cathepsin D and oestrogen receptor positive. Virchows Arch A Pathol Anat Histopathol 1993;423:497-502.","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"ref_19","first-page":"583","article-title":"p53 expression in human breast carcinoma: c-erbB-2 protein overexpression and oestrogen receptor","volume":"66","author":"Poller, D.N.; Hutchings, C.E.; Galea, M.; Bell, J.A.; Nicholson, R.A.; Elston, C.W.","year":"1992","unstructured":"Poller DN, Hutchings CE, Galea M, Bell JA, Nicholson RA, Elston CW, et al. p53 expression in human breast carcinoma: c-erbB-2 protein overexpression and oestrogen receptor. BrJ7 Cancer 1992;66:583-8."},{"key":"ref_20","first-page":"1731","article-title":"Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas","volume":"143","author":"Moll, R.; Mitze, M.; Frizen, U.H.; Birchmeier, W.","year":"1993","unstructured":"Moll R, Mitze M, Frizen UH, Birchmeier W. Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. AmJ7Pathol 1993;143: 1731-42."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/1097-0142(19930101)71:1<147::AID-CNCR2820710124>3.0.CO;2-V","article-title":"Relationship between breast histopathology and family history of breast cancer","volume":"71","author":"Claus, E.B.; Risch, N.; Thompson, W.D.; Carter, D.","year":"1993","unstructured":"Claus EB, Risch N, Thompson WD, Carter D. Relationship between breast histopathology and family history of breast cancer. Cancer 1993;71:147-53.","journal-title":"Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.2270482","article-title":"Linkage analysis of early onset familial breast cancer to chromosome 17ql2-21","volume":"250","author":"Hall, J.M.; Lee, M.K.; Morrow, J.; Newman, B.; Anderson, L.; Huey, B.","year":"1990","unstructured":"Hall JM, Lee MK, Morrow J, Newman B, Anderson L, Huey B, et al. Linkage analysis of early onset familial breast cancer to chromosome 17ql2-21. Science 1990; 250:1684-9.","journal-title":"Science"},{"key":"ref_23","first-page":"678","article-title":"Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families","volume":"52","author":"Easton, D.F.; Bishop, D.T.; Ford, D.; Crockford, G.P.","year":"1993","unstructured":"Easton DF, Bishop DT, Ford D, Crockford GP. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. Am J Hum Genet 1993;52: 678-701.","journal-title":"Am J Hum Genet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1126\/science.8091231","article-title":"Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q 12-13","volume":"265","author":"Wooster, R.; Neuhausen, S.L.; Mangion, J.; Quirk, Y.; Ford, D.; Collins, N.","year":"1994","unstructured":"Wooster R, Neuhausen SL, Mangion J, Quirk Y, Ford D, Collins N, et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q 12-13. Science 1994;265:2088-90.","journal-title":"Science"}],"container-title":["Clinical Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/mp.48.2.M74","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T17:28:04Z","timestamp":1756056484000},"score":1,"resource":{"primary":{"URL":"https:\/\/mp.bmj.com\/lookup\/doi\/10.1136\/mp.48.2.M74"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1995,4,1]]},"published-print":{"date-parts":[[1995,4]]}},"alternative-id":["10.1136\/mp.48.2.M74"],"URL":"https:\/\/doi.org\/10.1136\/mp.48.2.m74","relation":{},"ISSN":["1355-2910","1472-4154"],"issn-type":[{"value":"1355-2910","type":"print"},{"value":"1472-4154","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4]]}}}