{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T02:04:20Z","timestamp":1760061860220},"reference-count":17,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Pathology"],"published-print":{"date-parts":[[1998,2,1]]},"DOI":"10.1136\/mp.51.1.35","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:10:34Z","timestamp":1230768634000},"page":"35-38","source":"Crossref","is-referenced-by-count":7,"title":["Allelic imbalance and microsatellite instability of the DCC gene in colorectal cancer in patients under the age of 35 using fluorescent DNA technology"],"prefix":"10.1136","volume":"51","author":[{"given":"R.","family":"Chetty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Naidoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nm0995-902","article-title":"Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression","volume":"1","author":"Boland, C.R.; Sato, J.; Appelman, H.D.","year":"1995","unstructured":"Boland CR, Sato J, Appelman HD, et al. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nat Med 1995;1:902\u20139.","journal-title":"Nat Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nm0495-348","article-title":"Genetic instability occurs in the majority of young patients with colorectal cancer","volume":"1","author":"Liu, B.; Farrington, F.M.; Petersen, G.M.","year":"1995","unstructured":"Liu B, Farrington FM, Petersen GM, et al. Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med 1995;1:348\u201352.","journal-title":"Nat Med"},{"key":"ref_3","first-page":"3331","article-title":"Semiautomated assessment of loss of heterozygosity and replication error in tumors","volume":"56","author":"Canzian, F.; Salovaara, R.; Hemminki, A.","year":"1996","unstructured":"Canzian F, Salovaara R, Hemminki A, et al. Semiautomated assessment of loss of heterozygosity and replication error in tumors. Cancer Res 1996;56:3331\u20137.","journal-title":"Cancer Res"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/bjc.1994.404","article-title":"Frequency of allele loss of DCC, p53, RB1, WT1, NF1, NM23 and APC\/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction","volume":"70","author":"Cawkwell, L.; Lewis, F.A.; Quirke, P.","year":"1994","unstructured":"Cawkwell L, Lewis FA, Quirke P. Frequency of allele loss of DCC, p53, RB1, WT1, NF1, NM23 and APC\/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. Br J Cancer 1994;70:813\u20138.","journal-title":"Br J Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0016-5085(95)90334-8","article-title":"Microsatellite instability in colorectal cancer: improved assessment using fluorescent polymerase chain reaction","volume":"109","author":"Cawkwell, L.; Li, D.; Lewis, F.A.","year":"1995","unstructured":"Cawkwell L, Li D, Lewis FA, et al. Microsatellite instability in colorectal cancer: improved assessment using fluorescent polymerase chain reaction. Gastroenterology 1995;109: 465\u201371.","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/bjc.1993.236","article-title":"Rapid detection of allele loss in colorectal tumours using microsatellites and fluorescent DNA technology","volume":"67","author":"Cawkwell, L.; Bell, S.M.; Lewis, F.A.","year":"1993","unstructured":"Cawkwell L, Bell SM, Lewis FA, et al. Rapid detection of allele loss in colorectal tumours using microsatellites and fluorescent DNA technology. Br J Cancer 1993;67:1262\u20137.","journal-title":"Br J Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0959-8049(95)00128-6","article-title":"DCC: linking tumour suppressor genes and altered cell surface interactions in cancer?","volume":"31","author":"Cho, K.R.; Fearon, E.R.","year":"1995","unstructured":"Cho KR, Fearon ER. DCC: linking tumour suppressor genes and altered cell surface interactions in cancer? Eur J Cancer 1995;31A:1055\u201360.","journal-title":"Eur J Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1126\/science.2841761","article-title":"Concerted nonsyntenic allelic loss in human colorectal carcinoma","volume":"241","author":"Law, D.J.; Olschwang, S.; Monpezat, J.-P.","year":"1988","unstructured":"Law DJ, Olschwang S, Monpezat J-P, et al. Concerted nonsyntenic allelic loss in human colorectal carcinoma. Science 1988;241:961\u20135.","journal-title":"Science"},{"key":"ref_9","first-page":"87","article-title":"DCC\u2019s function takes shape in the nervous system. Curr Opin Genet Dev","volume":"7","author":"Kolodziej, P.A.","year":"1997","unstructured":"Kolodziej PA. DCC\u2019s function takes shape in the nervous system. Curr Opin Genet Dev 1997;7:87\u201392."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.8484121","article-title":"Clues to the pathogenesis of familial colorectal cancer","volume":"260","author":"Aaltonen, L.A.; Peltomaki, P.; Leach, F.S.","year":"1993","unstructured":"Aaltonen LA, Peltomaki P, Leach FS, et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993; 260:812\u20136.","journal-title":"Science"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/363558a0","article-title":"Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis","volume":"363","author":"Ionov, Y.; Peinado, M.A.; Malkhosyan, S.","year":"1993","unstructured":"Ionov Y, Peinado MA, Malkhosyan S, et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993; 363:558\u201361.","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.8484122","article-title":"Microsatellite instability in cancer of the proximal colon","volume":"260","author":"Thibodeau, S.N.; Bren, G.; Schaid, D.","year":"1993","unstructured":"Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993;260:816\u20139.","journal-title":"Science"},{"key":"ref_13","first-page":"5849","article-title":"Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history","volume":"53","author":"Lothe, R.A.; Peltomaki, P.; Meling, G.I.","year":"1993","unstructured":"Lothe RA, Peltomaki P, Meling GI, et al. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993;53:5849\u201352.","journal-title":"Cancer Res"},{"key":"ref_14","first-page":"1645","article-title":"Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients","volume":"54","author":"Aaltonen, L.A.; Peltomaki, P.; Mecklin, J.-P.","year":"1994","unstructured":"Aaltonen LA, Peltomaki P, Mecklin J-P, et al. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res 1994; 54:1645\u20138.","journal-title":"Cancer Res"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/0016-5085(95)90742-4","article-title":"Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer","volume":"109","author":"Samowitz, W.S.; Slattery, M.L.; Kerber, R.A.","year":"1995","unstructured":"Samowitz WS, Slattery ML, Kerber RA. Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer. Gastroenterology 1995;109:1765\u201371.","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/0016-5085(95)90774-2","article-title":"Microsatellite instability as an indicator of hereditary susceptibility to colon cancer","volume":"109","author":"Peltomaki, P.","year":"1995","unstructured":"Peltomaki P. Microsatellite instability as an indicator of hereditary susceptibility to colon cancer. Gastroenterology 1995;109:2031\u20133.","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/ng0195-48","article-title":"Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability","volume":"9","author":"Liu, B.; Nicolaides, N.C.; Markowitz, S.","year":"1995","unstructured":"Liu B, Nicolaides NC, Markowitz S, et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet 1995;9:48\u201355.","journal-title":"Nat Genet"}],"container-title":["Molecular Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/mp.51.1.35","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T22:55:43Z","timestamp":1601074543000},"score":1,"resource":{"primary":{"URL":"https:\/\/mp.bmj.com\/lookup\/doi\/10.1136\/mp.51.1.35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/mp.51.1.35","relation":{},"ISSN":["1366-8714"],"issn-type":[{"value":"1366-8714","type":"print"}],"subject":[],"published":{"date-parts":[[1998,2,1]]}}}