{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:16:08Z","timestamp":1762917368155,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2011,11,21]]},"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>To assess the short term efficacy of Cyberknife stereotactic radiosurgical treatment of trigeminal neuralgia (TN).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>17 consecutive patients with medically or surgically refractory unilateral TN were treated with Cyberknife radiosurgery. Using superimposed CT cisternogram and MR images, the target segment of the trigeminal nerve was consistently defined as a 6\u2005mm length of nerve approximately 2\u20133\u2005mm distal to the dorsal root entry zone of the brainstem. A radiosurgical rhizotomy was performed with the Cyberknife utilizing a single collimator to deliver an average maximum dose of 73.06\u2005Gy (range 72.91\u201373.73) to the target.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Follow-up data were available for 16 of the 17 patients post-treatment (range 1\u201327\u2005months, average 11.8\u2005months). Overall, 14 of 16 (88%) patients responded favorably with either partial or complete relief of symptomatology. 11 of these patients were successfully free of all pain at some point in their post-treatment course, with seven patients pain free to the last follow-up visit (average 5.0\u2005months, range 1\u201313\u2005months). Symptoms recurred in four patients, taking place at 3, 7.75, 9 and 18\u2005months after Cyberknife therapy. Only two patients reported side effects. One patient developed a bothersome feathery dysesthesia while the second patient reported a non-bothersome mild jaw hypoesthesia. There were no substantial complications related to stereotactic radiosurgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Cyberknife radiosurgery is a viable treatment alternative in patients with TN with competitive efficacy demonstrated in our group of patients while minimizing adverse effects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2011-010125","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T21:16:19Z","timestamp":1327526179000},"page":"81-85","source":"Crossref","is-referenced-by-count":25,"title":["Cyberknife radiosurgery in treating trigeminal neuralgia"],"prefix":"10.1136","volume":"5","author":[{"given":"Bryan M","family":"Lazzara","sequence":"first","affiliation":[{"name":"Department of Radiology, Winthrop-University Hospital, Mineola, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Winthrop-University Hospital, Mineola, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Bordia","sequence":"additional","affiliation":[{"name":"Department of Radiology, Winthrop-University Hospital, Mineola, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R","family":"Witten","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Winthrop-University Hospital, Mineola, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Winthrop-University Hospital, Mineola, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan J","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Winthrop-University Hospital, Mineola, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Winthrop-University Hospital, Mineola, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,1,25]]},"reference":[{"key":"2025092912462569000_5.1.81.1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.12.1524"},{"key":"2025092912462569000_5.1.81.2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000076661","article-title":"Gamma knife radiosurgery for trigeminal neuralgia: comparing the use of a 4-mm versus concentric 4- and 8-mm collimators","volume":"82","author":"Kanner","year":"2004","journal-title":"Stereotact Funct Neurosurg"},{"key":"2025092912462569000_5.1.81.3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1017\/S0317167100006351","article-title":"Trigeminal neuralgia: outcomes after gamma knife radiosurgery","volume":"36","author":"Knafo","year":"2009","journal-title":"Can J Neurol Sci"},{"key":"2025092912462569000_5.1.81.4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3171\/jns.2003.99.3.0511","article-title":"Dedicated linear accelerator radiosurgery for the treatment of trigeminal neuralgia","volume":"99","author":"Smith","year":"2003","journal-title":"J Neurosurg"},{"key":"2025092912462569000_5.1.81.5","doi-asserted-by":"publisher","DOI":"10.1159\/000056492"},{"key":"2025092912462569000_5.1.81.6","doi-asserted-by":"publisher","DOI":"10.3171\/2009.7.JNS09694"},{"key":"2025092912462569000_5.1.81.7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000029771","article-title":"Gamma knife radiosurgery for trigeminal neuralgia: experience at the Barrow Neurological Institute","volume":"73","author":"Han","year":"1999","journal-title":"Stereotact Funct Neurosurg"},{"issue":"Suppl 1","key":"2025092912462569000_5.1.81.8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000056421","article-title":"Gamma knife radiosurgery as the first surgery for trigeminal neuralgia","volume":"70","author":"Kondziolka","year":"1998","journal-title":"Stereotact Funct Neurosurg"},{"key":"2025092912462569000_5.1.81.9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3171\/jns.2006.104.6.913","article-title":"Prospective controlled trial of gamma knife surgery for essential trigeminal neuralgia","volume":"104","author":"Regis","year":"2006","journal-title":"J Neurosurg"},{"key":"2025092912462569000_5.1.81.10","doi-asserted-by":"publisher","DOI":"10.3171\/2009.2.JNS08977"},{"key":"2025092912462569000_5.1.81.11","doi-asserted-by":"publisher","DOI":"10.3171\/2009.8.JNS081706"},{"key":"2025092912462569000_5.1.81.12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3171\/jns.2001.94.1.0014","article-title":"Clinical outcomes after stereotactic radiosurgery for idiopathic trigeminal neuralgia","volume":"94","author":"Maesawa","year":"2001","journal-title":"J Neurosurg"},{"key":"2025092912462569000_5.1.81.13","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3171\/jns.2005.102.3.0434","article-title":"Gamma knife surgery for trigeminal neuralgia: outcomes and prognostic factors","volume":"102","author":"Sheehan","year":"2005","journal-title":"J Neurosurg"},{"key":"2025092912462569000_5.1.81.14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3171\/jns.2005.102.3.0442","article-title":"Stereotactic gamma knife surgery for trigeminal neuralgia: detailed analysis of treatment response","volume":"102","author":"Tawk","year":"2005","journal-title":"J Neurosurg"},{"key":"2025092912462569000_5.1.81.15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000094366","article-title":"Outcome of patients undergoing gamma knife stereotactic radiosurgery for medically refractory idiopathic trigeminal neuralgia: Medical College of Georgia's experience","volume":"84","author":"Fountas","year":"2006","journal-title":"Stereotact Funct Neurosurg"},{"issue":"Suppl 1","key":"2025092912462569000_5.1.81.16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000099734","article-title":"Trigeminal neuralgia radiosurgery: the University of Pittsburgh experience","volume":"66","author":"Kondziolka","year":"1996","journal-title":"Stereotact Funct Neurosurg"},{"key":"2025092912462569000_5.1.81.17","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1227\/01.neu.0000306104.68635.d4","article-title":"Gamma knife radiosurgery for trigeminal neuralgia: results and potentially predictive parameters\u2014part I: idiopathic trigeminal neuralgia","volume":"61","author":"Longhi","year":"2007","journal-title":"Neurosurgery"},{"key":"2025092912462569000_5.1.81.18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1227\/01.NEU.0000255393.77538.75","article-title":"Influence of nerve radiation dose in the incidence of trigeminal dysfunction after trigeminal neuralgia radiosurgery","volume":"60","author":"Massager","year":"2007","journal-title":"Neurosurgery"},{"key":"2025092912462569000_5.1.81.19","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200107000-00008"},{"issue":"2 Suppl","key":"2025092912462569000_5.1.81.20","doi-asserted-by":"crossref","first-page":"A84","DOI":"10.1227\/01.NEU.0000341631.49154.62","article-title":"Nonisocentric radiosurgical rhizotomy for trigeminal neuralgia","volume":"64","author":"Adler","year":"2009","journal-title":"Neurosurgery"},{"key":"2025092912462569000_5.1.81.21","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1227\/01.neu.0000317313.46826.dc","article-title":"Cyberknife radiosurgery for trigeminal neuralgia treatment: a preliminary multicenter experience","volume":"62","author":"Villavicencio","year":"2008","journal-title":"Neurosurgery"},{"key":"2025092912462569000_5.1.81.22","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.3171\/foc.2005.18.5.10","article-title":"CyberKnife radiosurgery for idiopathic trigeminal neuralgia","volume":"18","author":"Lim","year":"2005","journal-title":"Neurosurg Focus"},{"key":"2025092912462569000_5.1.81.23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000075112","article-title":"Cyberknife radiosurgery for trigeminal neuralgia","volume":"81","author":"Romanelli","year":"2003","journal-title":"Stereotact Funct Neurosurg"},{"key":"2025092912462569000_5.1.81.24","doi-asserted-by":"crossref","first-page":"A96","DOI":"10.1227\/01.NEU.0000341714.55023.8F","article-title":"CyberKnife radiosurgery as a first treatment for idiopathic trigeminal neuralgia","volume":"64","author":"Fariselli","year":"2009","journal-title":"Neurosurgery"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2011-010125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:46:33Z","timestamp":1759175193000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2011-010125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,25]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,12,12]]},"published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1136\/neurintsurg-2011-010125"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2011-010125","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"type":"print","value":"1759-8478"},{"type":"electronic","value":"1759-8486"}],"subject":[],"published":{"date-parts":[[2012,1,25]]}}}