{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:42:23Z","timestamp":1790055743290,"version":"4.0.1"},"reference-count":20,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2012,8,29]]},"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study evaluates whether thermoreversible gelation polymer (TGP) can be used as a delivery device to deploy dermal fibroblasts and cytokines into experimental aneurysms in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The right common iliac artery of rats was surgically ligated and an experimental aneurysm was created by applying exogenous elastase. Seven days later, two aneurysms were harvested and used as controls (Group A), two were embolized with pure TGP (Group B), two were embolized with TGP and basic fibroblast growth factor (bFGF) (Group C) and two were embolized with TGP loaded with rat dermal fibroblasts (Group D). The aneurysms were also embolized with TGP mixed with dermal fibroblasts and bFGF at different concentrations (10\u2005ng\/ml: Group E (n=2), 100\u2005ng\/ml: Group F (n=2), 1000\u2005ng\/ml: Group G (n=2)). Each aneurysm sample was harvested after 7\u2005days and histologic analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most advanced thrombus organization in the aneurysm, such as prominent fibroblast proliferation and collagen deposition, was observed in Groups E, F and G, although there was no noticeable difference between the groups. Moderate thrombus organization was seen in Group D and minimal thrombus organization was seen in Groups B and C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TGP mixed with both dermal fibroblasts and bFGF induced the most advanced thrombus organization in the experimental aneurysms followed by TGP mixed only with dermal fibroblasts. TGP may be useful as a delivery device to deploy fibroblasts and cytokines into aneurysms.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2012-010454","type":"journal-article","created":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T08:24:37Z","timestamp":1348647877000},"page":"586-590","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Thermoreversible gelation polymer as an embolic material for aneurysm treatment: a delivery device for dermal fibroblasts and basic fibroblast growing factor into experimental aneurysms in rats"],"prefix":"10.1136","volume":"5","author":[{"given":"Hisashi","family":"Dobashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Akasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Takao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"2024052223551512000_5.6.586.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000252128.83405.71"},{"key":"2024052223551512000_5.6.586.2","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/01.STR.26.9.1649","article-title":"Basic fibroblast growth factor may repair experimental cerebral aneurysms in rats","volume":"26","author":"Futami","year":"1995","journal-title":"Stroke"},{"key":"2024052223551512000_5.6.586.3","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.jvs.2008.05.060","article-title":"Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair: a canine model experiment","volume":"48","author":"Kajimoto","year":"2008","journal-title":"J Vasc Surg"},{"key":"2024052223551512000_5.6.586.4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1148\/radiology.207.2.9577504","article-title":"Platinum coil-mediated implantation of growth factor-secreting endovascular tissue grafts: an in vivo study","volume":"207","author":"Kallmes","year":"1998","journal-title":"Radiology"},{"key":"2024052223551512000_5.6.586.5","first-page":"1075","article-title":"Accelerated embolization healing of aneurysms by polyethylene terephthalate coils seeded with autologous fibroblasts","volume":"56","author":"Kawakami","year":"2005","journal-title":"Neurosurgery"},{"key":"2024052223551512000_5.6.586.6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1227\/01.NEU.0000073728.82721.8E","article-title":"Basic fibroblast growth factor released from a platinum coil with a polyvinyl alcohol core enhances cellular proliferation and vascular wall thickness: an in vitro and in vivo study","volume":"53","author":"Matsumoto","year":"2003","journal-title":"Neurosurgery"},{"key":"2024052223551512000_5.6.586.7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3171\/jns.2005.102.1.0109","article-title":"Immobilization of basic fibroblast growth factor on a platinum microcoil to enhance tissue organization in intracranial aneurysms","volume":"102","author":"Ohyama","year":"2005","journal-title":"J Neurosurg"},{"key":"2024052223551512000_5.6.586.8","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000279737.07683.57"},{"key":"2024052223551512000_5.6.586.9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3171\/JNS-07\/07\/0109","article-title":"Thrombus organization and healing in an experimental aneurysm model. 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