{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:08:12Z","timestamp":1760249292297},"reference-count":36,"publisher":"BMJ","issue":"Suppl 3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2013,2,14]]},"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Towards the translation of computational fluid dynamics (CFD) techniques into the clinical workflow, performance increases achieved with parallel multi-central processing unit (CPU) pulsatile CFD simulations in a patient-derived model of a bilobed posterior communicating artery aneurysm were evaluated while simultaneously monitoring changes in the accuracy of the solution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Simulations were performed using 2, 4, 6, 8, 10 and 12 processors. In addition, a baseline simulation was obtained with a dual-core dual CPU computer of similar computational power to clinical imaging workstations. Parallel performance indices including computation speed-up, efficiency (speed-up divided by number of processors), computational cost (computation time \u00d7 number of processors) and accuracy (velocity at four distinct locations: proximal and distal to the aneurysm, in the aneurysm ostium and aneurysm dome) were determined from the simulations and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total computation time decreased from 9\u2005h 10\u2005min (baseline) to 2\u2005h 34\u2005min (10\u2005CPU). Speed-up relative to baseline increased from 1.35 (2\u2005CPU) to 3.57 (maximum at 10\u2005CPU) while efficiency decreased from 0.65 to 0.35 with increasing cost (33.013 to 92.535). Relative velocity component deviations were less than 0.0073% and larger for 12\u2005CPU than for 2\u2005CPU (0.004\u00b10.002%, not statistically significant, p=0.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Without compromising accuracy, parallel multi-CPU simulation reduces computing time for the simulation of hemodynamics in a model of a cerebral aneurysm by up to a factor of 3.57 (10\u2005CPUs) to 2\u2005h 34\u2005min compared with a workstation with computational power similar to clinical imaging workstations.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2012-010586","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T00:50:51Z","timestamp":1363135851000},"page":"iii48-iii55","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Quantification of speed-up and accuracy of multi-CPU computational flow dynamics simulations of hemodynamics in a posterior communicating artery aneurysm of complex geometry"],"prefix":"10.1136","volume":"5","author":[{"given":"Christof","family":"Karmonik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasan","family":"Partovi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Horner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi J","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard P","family":"Klucznik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"2024052300220368000_5.Suppl_3.iii48.1","doi-asserted-by":"crossref","first-page":"iii91","DOI":"10.1146\/annurev.fluid.40.111406.102126","article-title":"Hemodynamics of cerebral aneurysms","volume":"41","author":"Sforza","year":"2009","journal-title":"Annu Rev Fluid Mech"},{"key":"2024052300220368000_5.Suppl_3.iii48.2","first-page":"iii1113","article-title":"Hemodynamics in a cerebral artery before and after the formation of an aneurysm","volume":"27","author":"Mantha","year":"2006","journal-title":"AJNR Am J 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