{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:16:36Z","timestamp":1793740596689,"version":"4.6.1"},"reference-count":22,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2013,8,18]]},"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Outcome studies in acute ischemic stroke (AIS) have focused on time from symptom onset to treatment. The purpose of this study was to investigate whether time to achieve vessel recanalization from groin puncture affects outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied all AIS cases that underwent intra-arterial therapy between May 2008 and October 2012 at a high volume center for anterior circulation occlusions. Candidacy for thrombectomy is determined by CT perfusion imaging, irrespective of time of onset. Patients were then dichotomized into two groups: \u2018Early recan\u2019 assigned in which recanalization was achieved in \u226460\u2005min from groin puncture and \u2018Delayed recan\u2019 in which procedures extended beyond 60\u2005min. Time to recanalize was also studied as a continuous variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>159 patients (53.5% women, mean age 66.4\u00b115.2\u2005years) were identified. The mean National Institutes of Health Stroke Scale (NIHSS) score was similar between \u2018Early recan\u2019 patients (16.8\u00b16.1) compared with \u2018Delayed recan\u2019 patients (15.4\u00b15.8, p=0.149). Among the \u2018Early recan\u2019 patients, recanalization was achieved in 40.7\u00b113.6\u2005min compared with 101.7\u00b132.5\u2005min in the \u2018Delayed recan\u2019 patients (p&lt;0.0001). The likelihood of achieving a good outcome (modified Rankin Scale score 0\u20132) was higher in the \u2018Early recan\u2019 group (53.6%) compared with the \u2018Late recan\u2019 group (30.8%; p=0.009). On logistic regression analysis, time to recanalization from groin puncture, baseline NIHSS, revascularization, diabetes, and hemorrhages were found to significantly impact on outcome at 90 days, as measured by the modified Rankin Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that extending mechanical thrombectomy procedure times beyond 60\u2005min increases complications and device cost rates while worsening outcomes. These findings can serve as a time frame of when it is prudent to abort a failed thrombectomy case.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/neurintsurg-2013-010726","type":"journal-article","created":{"date-parts":[[2013,9,7]],"date-time":"2013-09-07T21:21:07Z","timestamp":1378588867000},"page":"511-516","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":102,"title":["The golden hour of stroke intervention: effect of thrombectomy procedural time in acute ischemic stroke on outcome"],"prefix":"10.1136","volume":"6","author":[{"given":"Alejandro M","family":"Spiotta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Imran","family":"Chaudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Battenhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aquilla S","family":"Turk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,9,7]]},"reference":[{"key":"2024052300310992000_6.7.511.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191259"},{"key":"2024052300310992000_6.7.511.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"2024052300310992000_6.7.511.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61299-9"},{"key":"2024052300310992000_6.7.511.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61384-1"},{"key":"2024052300310992000_6.7.511.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000064841.47697.22"},{"key":"2024052300310992000_6.7.511.6","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.626903"},{"key":"2024052300310992000_6.7.511.7","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.544783"},{"key":"2024052300310992000_6.7.511.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000038987.62325.14"},{"key":"2024052300310992000_6.7.511.9","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000258112.14918.24"},{"key":"2024052300310992000_6.7.511.10","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.497115"},{"key":"2024052300310992000_6.7.511.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.07.003"},{"key":"2024052300310992000_6.7.511.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000179043.73314.4f"},{"key":"2024052300310992000_6.7.511.13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2003"},{"key":"2024052300310992000_6.7.511.14","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000199159.32210.E4"},{"key":"2024052300310992000_6.7.511.15","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200106000-00019"},{"key":"2024052300310992000_6.7.511.16","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1958"},{"key":"2024052300310992000_6.7.511.17","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2012-010486"},{"key":"2024052300310992000_6.7.511.18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/neurintsurg-2011-010080","article-title":"The Penumbra stroke system: a technical review","volume":"4","author":"Yoo","year":"2012","journal-title":"J Neurointerv Surgy"},{"key":"2024052300310992000_6.7.511.19","doi-asserted-by":"crossref","unstructured":"Turk AS Nyberg EM Chaudry MI . Utilization of CT perfusion patient selection for mechanical thrombectomy irrespective of time: a comparison of functional outcomes and complications. J Neurointerv Surg 2013;5:518\u201322.","DOI":"10.1136\/neurintsurg-2012-010452"},{"key":"2024052300310992000_6.7.511.20","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3202"},{"key":"2024052300310992000_6.7.511.21","doi-asserted-by":"crossref","unstructured":"Sun CH Nogueira RG Glenn BA . \u201cPicture to puncture\u201d: a novel time metric to enhance outcomes in patients transferred for endovascular reperfusion in acute ischemic stroke. Circulation 2013 ; 127 :1139\u201348.","DOI":"10.1161\/CIRCULATIONAHA.112.000506"},{"key":"2024052300310992000_6.7.511.22","doi-asserted-by":"crossref","unstructured":"Gupta R, Horev A, Nguyen T, et al. Higher volume endovascular stroke centers have faster times to treatment, higher reperfusion rates and higher rates of good clinical outcomes. J Neurointerv Surg 2013 Jul;5(4):294\u20137. doi: 10.1136\/neurintsurg-2011-010245. 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