{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:21:50Z","timestamp":1782602510802,"version":"3.54.5"},"reference-count":26,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2013,8,22]]},"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Axium MicroFX coils contain polymer (polyglycolic\/polylactic acid, PGLA) microfilaments designed to significantly impact intra-aneurysmal flow and to encourage aneurysm thrombosis. To provide preliminary evaluation of the safety and suggested efficacy of the MicroFX design, we performed a multicenter prospective single-arm trial, Axium<jats:underline>M<\/jats:underline>icroFX for<jats:underline>E<\/jats:underline>ndovascular<jats:underline>R<\/jats:underline>epair of<jats:underline>I<\/jats:underline>ntra<jats:underline>C<\/jats:underline>ranial Aneurysm study (AMERICA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AMERICA is a prospective multicenter 100 aneurysm observational study evaluating the safety and efficacy of Axium MicroFX PGLA coils. Enrollment was started in April 2010 and completed in October 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>99 patients underwent treatment for 100 aneurysms at 13 centers. Mean age was 60.2\u2005years, most were women (72%) and 18% of patients had previously undergone treatment for a separate aneurysm. 22% of patients underwent treatment after acute aneurysmal subarachnoid hemorrhage (SAH). Of these patients, all were Hunt and Hess grade 1\u20133. Pre-procedure modified Rankin score (mRS) was 0\u20132 in 92% of patients. The majority of aneurysms were anterior circulation (86%), with the most common aneurysm locations being the anterior communicating artery (23%) followed by the supraclinoid internal carotid artery and posterior communicating artery (18% each). The mean maximum diameter was 6.5\u2005mm. Axium MicroFX coils could be placed in all but one treatment (99%). Raymond grade at conclusion of coiling was I (complete) in 52%, II (dog ear or residual neck) in 33% and III (residual aneurysm) in 15%. Discharge mRS was significantly worse in patients with SAH (62% mRS 0\u20132) compared with electively treated aneurysms (mRS 0\u20132 in 94%, p&lt;001). Major events were uncommon (6% thromboembolic events, 3% intraoperative vessel or aneurysm rupture) and device-related adverse events (AE) were rare (2% of cases).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This prospective study of Axium MicroFX coils demonstrates excellent aneurysm occlusion rates. 52% of aneurysms were completely occluded post-procedure. Within the ruptured aneurysm group, post-procedure occlusion rates were 63.6%. Major AE rates were consistent with historical data.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2013-010887","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T02:13:22Z","timestamp":1378952002000},"page":"495-499","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Early results of the Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm (AMERICA) study: a multicenter prospective observational registry"],"prefix":"10.1136","volume":"6","author":[{"given":"Kyle M","family":"Fargen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiros","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Jabbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansaar T","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan H","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond D","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,9,11]]},"reference":[{"key":"2024052300524257000_6.7.495.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11314-6"},{"key":"2024052300524257000_6.7.495.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13860-3"},{"key":"2024052300524257000_6.7.495.3","doi-asserted-by":"publisher","DOI":"10.3171\/2011.8.JNS101767"},{"key":"2024052300524257000_6.7.495.4","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.5.0959"},{"key":"2024052300524257000_6.7.495.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000073841.88563.E9"},{"key":"2024052300524257000_6.7.495.6","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.657254"},{"key":"2024052300524257000_6.7.495.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60408-X"},{"key":"2024052300524257000_6.7.495.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000014423.20476.EE"},{"key":"2024052300524257000_6.7.495.9","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000194190.45595.9E"},{"key":"2024052300524257000_6.7.495.10","first-page":"1921","article-title":"Short-term outcome of intracranial aneurysms treated with polyglycolic acid\/lactide copolymer-coated coils compared to historical controls treated with bare platinum coils: a single-center experience","volume":"26","author":"Kang","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024052300524257000_6.7.495.11","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000177532.94736.85"},{"key":"2024052300524257000_6.7.495.12","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.2.192"},{"key":"2024052300524257000_6.7.495.13","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000206459.73897.a3"},{"key":"2024052300524257000_6.7.495.14","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0738"},{"key":"2024052300524257000_6.7.495.15","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.520866"},{"key":"2024052300524257000_6.7.495.16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00234-011-0870-2","article-title":"Intracranial aneurysm coiling with PGLA-coated coils versus bare platinum coils: long-term anatomic follow-up","volume":"54","author":"Piotin","year":"2012","journal-title":"Neuroradiology"},{"key":"2024052300524257000_6.7.495.17","unstructured":"Johnston SC McDougall CG Gholkar A . 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