{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:23:47Z","timestamp":1791203027718,"version":"4.2.0"},"reference-count":24,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2014,10,13]]},"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The pipeline embolization device (PED) necessitates dual antiplatelet therapy (APT) to decrease thrombotic complications while possibly increasing bleeding risks. The role of APT dose, duration, and response in patients with hemorrhagic and thromboembolic events warrants further analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A PubMed and Google Scholar search from 2009 to 2014 was performed using the following search terms individually or in combination: pipeline embolization device, aneurysm(s), and flow diversion, excluding other flow diverters. Review of the bibliographies of the retrieved articles yielded 19 single and multicenter studies. A statistical meta-analysis between aspirin (ASA) dose (low dose \u2264160\u2005mg, high dose \u2265300\u2005mg), loading doses of APT agents, post-PED APT regimens, and platelet function testing (PFT) with hemorrhagic or thrombotic complications was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ASA therapy for \u22646\u2005months post-PED was associated with increased hemorrhagic events. High dose ASA \u22646\u2005months post-PED was associated with fewer thrombotic events compared with low dose ASA. Post-PED clopidogrel for \u22646\u2005months demonstrated an increased incidence of symptomatic thrombotic events. Loading doses of ASA plus clopidogrel demonstrated a decreased incidence of permanent symptomatic hemorrhagic events. PFT did not show a statistically significant relationship with symptomatic hemorrhagic or thrombotic complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High dose ASA &gt;6\u2005months is associated with fewer permanent thrombotic and hemorrhagic events. Clopidogrel therapy \u22646\u2005months is associated with higher rates of thrombotic events. Loading doses of ASA and clopidogrel were associated with a decreased incidence of hemorrhagic events. PFT did not have any significant association with symptomatic events.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2014-011145","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T05:24:22Z","timestamp":1415683462000},"page":"58-65","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":104,"title":["Effect of antiplatelet therapy and platelet function testing on hemorrhagic and thrombotic complications in patients with cerebral aneurysms treated with the pipeline embolization device: a review and meta-analysis"],"prefix":"10.1136","volume":"8","author":[{"given":"Susana L","family":"Skukalek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne 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