{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:52:55Z","timestamp":1765885975659},"reference-count":25,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2014,8,19]]},"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Reduced cerebrovascular reserve (CVR) is associated with increased risk of ischemic events in carotid steno-occlusive diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether pretreatment CVR can predict postoperative ischemic lesions after carotid artery stenting (CAS)\u00a0by retrospective analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the medical records of 46 patients (42 men; mean age 74.2\u00b18.3\u2005years) who underwent CAS and preprocedural cerebral blood flow measurement by quantitative single-photon emission CT. Ischemic lesions were evaluated by diffusion-weighted image (DWI) within 72\u2005h after the intervention. We also evaluated plaque characteristics using black-blood MR plaque imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>New ipsilateral DWI-positive lesions were found in 11 cases (23.9%). Patients were classified into two groups based on the presence or absence of new DWI-positive lesions, and no significant differences in characteristics were found between the DWI-positive and DWI-negative groups, except for age and CVR of the ipsilateral middle cerebral artery (MCA) territory. The DWI-positive group was significantly older than the DWI-negative group (79.7\u00b14.1 vs 72.5\u00b18.6\u2005years; p=0.0085) and had lower average regional CVR (1.4\u00b118.2% vs 22.4\u00b125.8%; p=0.016). MR plaque imaging showed no significant difference in relative overall plaque MR signal intensity between the two groups (1.53\u00b10.37 vs 1.34\u00b10.26; p=0.113). In multivariate logistic regression analysis, lower CVR of the ipsilateral MCA territory (&lt;11%) was the only independent risk factor for new ischemic lesions following CAS (OR=6.99; 95% CI 1.17 to 41.80; p=0.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Impaired pretreatment CVR was associated with increased incidence of new infarction after CAS.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2014-011163","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T15:56:39Z","timestamp":1409846199000},"page":"576-580","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Reduced cerebrovascular reserve is associated with an increased risk of postoperative ischemic lesions during carotid artery 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